Effects of renal denervation on tubular sodium handling in rats with CBL-induced liver cirrhosis
This study was designed to examine the effect of bilateral renal denervation (DNX) on thick ascending limb of Henle's loop (TAL) function in rats with liver cirrhosis induced by common bile duct ligation (CBL). The CBL rats had, as previously shown, sodium retention associated with hypertrophy...
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| Veröffentlicht in: | American journal of physiology. Renal physiology 2003-03, Vol.284 (3), p.F555-F563 |
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| container_title | American journal of physiology. Renal physiology |
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| creator | Jonassen, Thomas E N Brønd, Lone Torp, Malene Graebe, Martin Nielsen, Søren Skøtt, Ole Marcussen, Niels Christensen, Sten |
| description | This study was designed to examine the effect of bilateral renal denervation (DNX) on thick ascending limb of Henle's loop (TAL) function in rats with liver cirrhosis induced by common bile duct ligation (CBL). The CBL rats had, as previously shown, sodium retention associated with hypertrophy of the inner stripe of the outer medulla (ISOM) and increased natriuretic effect of furosemide in vivo, and semiquantitative immunoblotting showed increased expression of the furosemide-sensitive Na-K-2Cl cotransporter type 2 (NKCC2) in ISOM from CBL rats. DNX significantly attenuated the sodium retention in the CBL rats, which was associated with normalization of the natriuretic effect of furosemide, as well as a significant reduction in the expression of NKCC2 in the ISOM. However, the marked hypertrophy of the ISOM found in CBL rats was not reversed by DNX. Together, these data indicate that increased renal sympathetic nerve activity known to be present in CBL rats plays a significant role in the formation of sodium retention by stimulating sodium reabsorption in the TAL via increased renal abundance of NKCC2. |
| doi_str_mv | 10.1152/ajprenal.00258.2002 |
| format | Article |
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The CBL rats had, as previously shown, sodium retention associated with hypertrophy of the inner stripe of the outer medulla (ISOM) and increased natriuretic effect of furosemide in vivo, and semiquantitative immunoblotting showed increased expression of the furosemide-sensitive Na-K-2Cl cotransporter type 2 (NKCC2) in ISOM from CBL rats. DNX significantly attenuated the sodium retention in the CBL rats, which was associated with normalization of the natriuretic effect of furosemide, as well as a significant reduction in the expression of NKCC2 in the ISOM. However, the marked hypertrophy of the ISOM found in CBL rats was not reversed by DNX. Together, these data indicate that increased renal sympathetic nerve activity known to be present in CBL rats plays a significant role in the formation of sodium retention by stimulating sodium reabsorption in the TAL via increased renal abundance of NKCC2.</description><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 1522-1466</identifier><identifier>DOI: 10.1152/ajprenal.00258.2002</identifier><identifier>PMID: 12441306</identifier><language>eng</language><publisher>United States</publisher><subject>Aldosterone - blood ; Animals ; Common Bile Duct - physiology ; Denervation ; Disease Models, Animal ; Diuretics - pharmacology ; Female ; Furosemide - pharmacology ; Kidney - drug effects ; Kidney - innervation ; Kidney - metabolism ; Kidney Function Tests ; Kidney Medulla - metabolism ; Ligation ; Liver Cirrhosis, Experimental - metabolism ; Loop of Henle - drug effects ; Loop of Henle - metabolism ; Rats ; Rats, Wistar ; Renin - blood ; Sodium - metabolism ; Sodium, Dietary ; Sodium-Hydrogen Exchanger 3 ; Sodium-Hydrogen Exchangers - metabolism ; Sodium-Potassium-Chloride Symporters - metabolism ; Solute Carrier Family 12, Member 1</subject><ispartof>American journal of physiology. 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Renal physiology</title><addtitle>Am J Physiol Renal Physiol</addtitle><description>This study was designed to examine the effect of bilateral renal denervation (DNX) on thick ascending limb of Henle's loop (TAL) function in rats with liver cirrhosis induced by common bile duct ligation (CBL). The CBL rats had, as previously shown, sodium retention associated with hypertrophy of the inner stripe of the outer medulla (ISOM) and increased natriuretic effect of furosemide in vivo, and semiquantitative immunoblotting showed increased expression of the furosemide-sensitive Na-K-2Cl cotransporter type 2 (NKCC2) in ISOM from CBL rats. DNX significantly attenuated the sodium retention in the CBL rats, which was associated with normalization of the natriuretic effect of furosemide, as well as a significant reduction in the expression of NKCC2 in the ISOM. However, the marked hypertrophy of the ISOM found in CBL rats was not reversed by DNX. Together, these data indicate that increased renal sympathetic nerve activity known to be present in CBL rats plays a significant role in the formation of sodium retention by stimulating sodium reabsorption in the TAL via increased renal abundance of NKCC2.</description><subject>Aldosterone - blood</subject><subject>Animals</subject><subject>Common Bile Duct - physiology</subject><subject>Denervation</subject><subject>Disease Models, Animal</subject><subject>Diuretics - pharmacology</subject><subject>Female</subject><subject>Furosemide - pharmacology</subject><subject>Kidney - drug effects</subject><subject>Kidney - innervation</subject><subject>Kidney - metabolism</subject><subject>Kidney Function Tests</subject><subject>Kidney Medulla - metabolism</subject><subject>Ligation</subject><subject>Liver Cirrhosis, Experimental - metabolism</subject><subject>Loop of Henle - drug effects</subject><subject>Loop of Henle - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renin - blood</subject><subject>Sodium - metabolism</subject><subject>Sodium, Dietary</subject><subject>Sodium-Hydrogen Exchanger 3</subject><subject>Sodium-Hydrogen Exchangers - metabolism</subject><subject>Sodium-Potassium-Chloride Symporters - metabolism</subject><subject>Solute Carrier Family 12, Member 1</subject><issn>1931-857X</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtLAzEQhYMoVqu_QJA8-bY1t709aqkXKPii4FvMJhObss3WZLfivze9iDBwBuacA_MhdEXJhNKc3arlOoBX7YQQllcTluQInaULy6goiuO015xmVV6-j9B5jEtCCKWMnqIRZUJQTooz9DGzFnQfcWfxrg0b8BA2qnedx2n6oRlaFXDsjBtWeKG8aZ3_xM7joFLu2_ULPL2fZ86bQYPBrdtAwNqFsOiiixfoxKo2wuVBx-jtYfY6fcrmL4_P07t5pnlN-0wBA6EVr5WtDRG0sJblnDW2tpSWImd5o4ywpW5IRdKrHExjFOS5UlAJDnyMbva969B9DRB7uXJRQ9sqD90QZcnqKv1Mk5HvjTp0MQawch3cSoUfSYncgpV_YOUOrNyCTanrQ_3QrMD8Zw4k-S8U83fq</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>Jonassen, Thomas E N</creator><creator>Brønd, Lone</creator><creator>Torp, Malene</creator><creator>Graebe, Martin</creator><creator>Nielsen, Søren</creator><creator>Skøtt, Ole</creator><creator>Marcussen, Niels</creator><creator>Christensen, Sten</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>Effects of renal denervation on tubular sodium handling in rats with CBL-induced liver cirrhosis</title><author>Jonassen, Thomas E N ; Brønd, Lone ; Torp, Malene ; Graebe, Martin ; Nielsen, Søren ; Skøtt, Ole ; Marcussen, Niels ; Christensen, Sten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-ae2e4ca39af9d0416ff2532bf9f1174525bad4f7cb0802003edbdae55aae843e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aldosterone - blood</topic><topic>Animals</topic><topic>Common Bile Duct - physiology</topic><topic>Denervation</topic><topic>Disease Models, Animal</topic><topic>Diuretics - pharmacology</topic><topic>Female</topic><topic>Furosemide - pharmacology</topic><topic>Kidney - drug effects</topic><topic>Kidney - innervation</topic><topic>Kidney - metabolism</topic><topic>Kidney Function Tests</topic><topic>Kidney Medulla - metabolism</topic><topic>Ligation</topic><topic>Liver Cirrhosis, Experimental - metabolism</topic><topic>Loop of Henle - drug effects</topic><topic>Loop of Henle - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renin - blood</topic><topic>Sodium - metabolism</topic><topic>Sodium, Dietary</topic><topic>Sodium-Hydrogen Exchanger 3</topic><topic>Sodium-Hydrogen Exchangers - metabolism</topic><topic>Sodium-Potassium-Chloride Symporters - metabolism</topic><topic>Solute Carrier Family 12, Member 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jonassen, Thomas E N</creatorcontrib><creatorcontrib>Brønd, Lone</creatorcontrib><creatorcontrib>Torp, Malene</creatorcontrib><creatorcontrib>Graebe, Martin</creatorcontrib><creatorcontrib>Nielsen, Søren</creatorcontrib><creatorcontrib>Skøtt, Ole</creatorcontrib><creatorcontrib>Marcussen, Niels</creatorcontrib><creatorcontrib>Christensen, Sten</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Renal physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jonassen, Thomas E N</au><au>Brønd, Lone</au><au>Torp, Malene</au><au>Graebe, Martin</au><au>Nielsen, Søren</au><au>Skøtt, Ole</au><au>Marcussen, Niels</au><au>Christensen, Sten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of renal denervation on tubular sodium handling in rats with CBL-induced liver cirrhosis</atitle><jtitle>American journal of physiology. Renal physiology</jtitle><addtitle>Am J Physiol Renal Physiol</addtitle><date>2003-03</date><risdate>2003</risdate><volume>284</volume><issue>3</issue><spage>F555</spage><epage>F563</epage><pages>F555-F563</pages><issn>1931-857X</issn><eissn>1522-1466</eissn><abstract>This study was designed to examine the effect of bilateral renal denervation (DNX) on thick ascending limb of Henle's loop (TAL) function in rats with liver cirrhosis induced by common bile duct ligation (CBL). The CBL rats had, as previously shown, sodium retention associated with hypertrophy of the inner stripe of the outer medulla (ISOM) and increased natriuretic effect of furosemide in vivo, and semiquantitative immunoblotting showed increased expression of the furosemide-sensitive Na-K-2Cl cotransporter type 2 (NKCC2) in ISOM from CBL rats. DNX significantly attenuated the sodium retention in the CBL rats, which was associated with normalization of the natriuretic effect of furosemide, as well as a significant reduction in the expression of NKCC2 in the ISOM. However, the marked hypertrophy of the ISOM found in CBL rats was not reversed by DNX. Together, these data indicate that increased renal sympathetic nerve activity known to be present in CBL rats plays a significant role in the formation of sodium retention by stimulating sodium reabsorption in the TAL via increased renal abundance of NKCC2.</abstract><cop>United States</cop><pmid>12441306</pmid><doi>10.1152/ajprenal.00258.2002</doi></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aldosterone - blood Animals Common Bile Duct - physiology Denervation Disease Models, Animal Diuretics - pharmacology Female Furosemide - pharmacology Kidney - drug effects Kidney - innervation Kidney - metabolism Kidney Function Tests Kidney Medulla - metabolism Ligation Liver Cirrhosis, Experimental - metabolism Loop of Henle - drug effects Loop of Henle - metabolism Rats Rats, Wistar Renin - blood Sodium - metabolism Sodium, Dietary Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - metabolism Sodium-Potassium-Chloride Symporters - metabolism Solute Carrier Family 12, Member 1 |
| title | Effects of renal denervation on tubular sodium handling in rats with CBL-induced liver cirrhosis |
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