Effects of Epidural and Spinal Anesthesia on Blood Rheology
This study was designed to compare the influence of epidural and spinal anesthesia on blood viscosity. We studied 22 patients, ASA classification I, who underwent elective knee or ankle arthroscopy and received epidural (n = 11) or spinal (n = 11) anesthesia with plain bupivacaine, and 10 control vo...
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| Veröffentlicht in: | Anesthesia and analgesia 1992-06, Vol.74 (6), p.835-840 |
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| container_title | Anesthesia and analgesia |
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| creator | Odoom, Joseph A. Bovill, James G. Hardeman, Max R. Oosting, Johannes Zuurmond, Wouter W. A. |
| description | This study was designed to compare the influence of epidural and spinal anesthesia on blood viscosity. We studied 22 patients, ASA classification I, who underwent elective knee or ankle arthroscopy and received epidural (n = 11) or spinal (n = 11) anesthesia with plain bupivacaine, and 10 control volunteers, who did not undergo surgery or receive anesthesia. There were significant decreases in hematocrit, plasma viscosity, and whole-blood viscosity at high (70 s), medium (0.5 s), and low (0.05 s) shear rates. The magnitude of changes was similar in all groups but occurred earlier in the control group (between 10 and 30 min) and after spinal administration (between 10 and 30 min) rather than after epidural administration (between 30 and 60 min) of bupivacaine. Only spinal anesthesia was associated with a decrease in erythrocyte deformability. The observed rheologic changes are attributed to hemodilution from the intravenous administration of fluids and the redistribution of fluid in the intravascular and extravascular compartments after sympathetic blockade and to postural changes rather than the effect of bupivacaine on blood elements. |
| doi_str_mv | 10.1213/00000539-199206000-00010 |
| format | Article |
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Only spinal anesthesia was associated with a decrease in erythrocyte deformability. The observed rheologic changes are attributed to hemodilution from the intravenous administration of fluids and the redistribution of fluid in the intravascular and extravascular compartments after sympathetic blockade and to postural changes rather than the effect of bupivacaine on blood elements.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/00000539-199206000-00010</identifier><identifier>PMID: 1595916</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Adult ; Anesthesia ; Anesthesia, Epidural ; Anesthesia, Spinal ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Ankle Joint - surgery ; Arthroscopy ; Biological and medical sciences ; Blood Viscosity - drug effects ; Bupivacaine ; Female ; Hematocrit ; Humans ; Knee Joint - surgery ; Local anesthesia. 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A.</creatorcontrib><title>Effects of Epidural and Spinal Anesthesia on Blood Rheology</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>This study was designed to compare the influence of epidural and spinal anesthesia on blood viscosity. We studied 22 patients, ASA classification I, who underwent elective knee or ankle arthroscopy and received epidural (n = 11) or spinal (n = 11) anesthesia with plain bupivacaine, and 10 control volunteers, who did not undergo surgery or receive anesthesia. There were significant decreases in hematocrit, plasma viscosity, and whole-blood viscosity at high (70 s), medium (0.5 s), and low (0.05 s) shear rates. The magnitude of changes was similar in all groups but occurred earlier in the control group (between 10 and 30 min) and after spinal administration (between 10 and 30 min) rather than after epidural administration (between 30 and 60 min) of bupivacaine. Only spinal anesthesia was associated with a decrease in erythrocyte deformability. The observed rheologic changes are attributed to hemodilution from the intravenous administration of fluids and the redistribution of fluid in the intravascular and extravascular compartments after sympathetic blockade and to postural changes rather than the effect of bupivacaine on blood elements.</description><subject>Adult</subject><subject>Anesthesia</subject><subject>Anesthesia, Epidural</subject><subject>Anesthesia, Spinal</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Ankle Joint - surgery</subject><subject>Arthroscopy</subject><subject>Biological and medical sciences</subject><subject>Blood Viscosity - drug effects</subject><subject>Bupivacaine</subject><subject>Female</subject><subject>Hematocrit</subject><subject>Humans</subject><subject>Knee Joint - surgery</subject><subject>Local anesthesia. Pain (treatment)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Time Factors</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVtLwzAUgIMoc05_gtAH8a2aNG3T4NMc8wKC4OU5nLYnrpo1M2kZ-_dmF-eTgZCTnO_khC-ERIxesYTxa7oeGZcxkzKhedjEYTJ6QIYsS_JYZLI4JMNwxuNESnlMTrz_3CBFPiADlslMsnxIbqZaY9X5yOpoumjq3oGJoK2j10XThnDcou9m6BuIbBvdGmvr6GWG1tiP1Sk50mA8nu3WEXm_m75NHuKn5_vHyfgprlIhaZxrIWqh05LK0J8VpSwFSE5FhUWKDKqUcl1yFEWSJkCpkGUNoCWWGYAokI_I5fbehbPffXiPmje-QmOgRdt7JRJZcC6yABZbsHLWe4daLVwzB7dSjKq1N_XrTe29qY2UUHq-69GXc6z_CreiQv5ilwdfgdEO2qrxeywLknmeBCzdYktrOnT-y_RLdGqGYLqZ-u_X-A8_ZoMh</recordid><startdate>199206</startdate><enddate>199206</enddate><creator>Odoom, Joseph A.</creator><creator>Bovill, James G.</creator><creator>Hardeman, Max R.</creator><creator>Oosting, Johannes</creator><creator>Zuurmond, Wouter W. A.</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199206</creationdate><title>Effects of Epidural and Spinal Anesthesia on Blood Rheology</title><author>Odoom, Joseph A. ; Bovill, James G. ; Hardeman, Max R. ; Oosting, Johannes ; Zuurmond, Wouter W. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4790-6f77d7f4b0900118b9b7a9307ce84e1ac403fb3e78242a0079bdaaf9eb5aa78e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Anesthesia</topic><topic>Anesthesia, Epidural</topic><topic>Anesthesia, Spinal</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Ankle Joint - surgery</topic><topic>Arthroscopy</topic><topic>Biological and medical sciences</topic><topic>Blood Viscosity - drug effects</topic><topic>Bupivacaine</topic><topic>Female</topic><topic>Hematocrit</topic><topic>Humans</topic><topic>Knee Joint - surgery</topic><topic>Local anesthesia. Pain (treatment)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Odoom, Joseph A.</creatorcontrib><creatorcontrib>Bovill, James G.</creatorcontrib><creatorcontrib>Hardeman, Max R.</creatorcontrib><creatorcontrib>Oosting, Johannes</creatorcontrib><creatorcontrib>Zuurmond, Wouter W. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Odoom, Joseph A.</au><au>Bovill, James G.</au><au>Hardeman, Max R.</au><au>Oosting, Johannes</au><au>Zuurmond, Wouter W. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Epidural and Spinal Anesthesia on Blood Rheology</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1992-06</date><risdate>1992</risdate><volume>74</volume><issue>6</issue><spage>835</spage><epage>840</epage><pages>835-840</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>This study was designed to compare the influence of epidural and spinal anesthesia on blood viscosity. We studied 22 patients, ASA classification I, who underwent elective knee or ankle arthroscopy and received epidural (n = 11) or spinal (n = 11) anesthesia with plain bupivacaine, and 10 control volunteers, who did not undergo surgery or receive anesthesia. There were significant decreases in hematocrit, plasma viscosity, and whole-blood viscosity at high (70 s), medium (0.5 s), and low (0.05 s) shear rates. The magnitude of changes was similar in all groups but occurred earlier in the control group (between 10 and 30 min) and after spinal administration (between 10 and 30 min) rather than after epidural administration (between 30 and 60 min) of bupivacaine. Only spinal anesthesia was associated with a decrease in erythrocyte deformability. The observed rheologic changes are attributed to hemodilution from the intravenous administration of fluids and the redistribution of fluid in the intravascular and extravascular compartments after sympathetic blockade and to postural changes rather than the effect of bupivacaine on blood elements.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>1595916</pmid><doi>10.1213/00000539-199206000-00010</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Anesthesia Anesthesia, Epidural Anesthesia, Spinal Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Ankle Joint - surgery Arthroscopy Biological and medical sciences Blood Viscosity - drug effects Bupivacaine Female Hematocrit Humans Knee Joint - surgery Local anesthesia. Pain (treatment) Male Medical sciences Middle Aged Time Factors |
| title | Effects of Epidural and Spinal Anesthesia on Blood Rheology |
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