Prevention of diet-induced type 2 diabetes in the C57BL/6J mouse model by an antidiabetic herbal formula

Significant positive effects of an antidiabetes herbal formula (ADHF) on the prevention of progressive diet‐induced type 2 diabetes (NIDDM) in the well recognized C57BL/6J mouse model were demonstrated. The results of the present studies confirm that C57BL/6J mice, through a genetic predisposition,...

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Veröffentlicht in:Phytotherapy research 2003-01, Vol.17 (1), p.48-55
Hauptverfasser: Huo, Yushu, Winters, Wendell D., Yao, Da-lin
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container_title Phytotherapy research
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creator Huo, Yushu
Winters, Wendell D.
Yao, Da-lin
description Significant positive effects of an antidiabetes herbal formula (ADHF) on the prevention of progressive diet‐induced type 2 diabetes (NIDDM) in the well recognized C57BL/6J mouse model were demonstrated. The results of the present studies confirm that C57BL/6J mice, through a genetic predisposition, developed NIDDM‐like symptoms on a regular schedule when fed solely on a diabetes induction diet containing high fat, high simple carbohydrate and low fibre. Blood glucose levels consistent with type 2 diabetes were detected after 8 weeks on this induction diet. In contrast, no members of the prevention study groups of C57BL/6J mice, which had ADHF mixed into their diabetes induction diet, developed progressive evidence of NIDDM‐like symptoms. Specific parameters observed to be significantly reduced in mice in the prevention diet groups fed ADHF mixed into the diabetes induction diet compared with the diabetes positive control groups fed diabetes induction diet only were clinical signs, blood glucose and serum insulin levels, insulin resistance and histopathological changes in major organs. This is the first report to our knowledge to show in vivo evidence for the successful prevention of progressive NIDDM‐like symptoms by the addition of an anti‐diabetes herbal formula to a effective diabetes induction diet. Copyright © 2003 John Wiley & Sons, Ltd.
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The results of the present studies confirm that C57BL/6J mice, through a genetic predisposition, developed NIDDM‐like symptoms on a regular schedule when fed solely on a diabetes induction diet containing high fat, high simple carbohydrate and low fibre. Blood glucose levels consistent with type 2 diabetes were detected after 8 weeks on this induction diet. In contrast, no members of the prevention study groups of C57BL/6J mice, which had ADHF mixed into their diabetes induction diet, developed progressive evidence of NIDDM‐like symptoms. Specific parameters observed to be significantly reduced in mice in the prevention diet groups fed ADHF mixed into the diabetes induction diet compared with the diabetes positive control groups fed diabetes induction diet only were clinical signs, blood glucose and serum insulin levels, insulin resistance and histopathological changes in major organs. This is the first report to our knowledge to show in vivo evidence for the successful prevention of progressive NIDDM‐like symptoms by the addition of an anti‐diabetes herbal formula to a effective diabetes induction diet. 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Res</addtitle><description>Significant positive effects of an antidiabetes herbal formula (ADHF) on the prevention of progressive diet‐induced type 2 diabetes (NIDDM) in the well recognized C57BL/6J mouse model were demonstrated. The results of the present studies confirm that C57BL/6J mice, through a genetic predisposition, developed NIDDM‐like symptoms on a regular schedule when fed solely on a diabetes induction diet containing high fat, high simple carbohydrate and low fibre. Blood glucose levels consistent with type 2 diabetes were detected after 8 weeks on this induction diet. In contrast, no members of the prevention study groups of C57BL/6J mice, which had ADHF mixed into their diabetes induction diet, developed progressive evidence of NIDDM‐like symptoms. Specific parameters observed to be significantly reduced in mice in the prevention diet groups fed ADHF mixed into the diabetes induction diet compared with the diabetes positive control groups fed diabetes induction diet only were clinical signs, blood glucose and serum insulin levels, insulin resistance and histopathological changes in major organs. This is the first report to our knowledge to show in vivo evidence for the successful prevention of progressive NIDDM‐like symptoms by the addition of an anti‐diabetes herbal formula to a effective diabetes induction diet. 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Res</addtitle><date>2003-01</date><risdate>2003</risdate><volume>17</volume><issue>1</issue><spage>48</spage><epage>55</epage><pages>48-55</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Significant positive effects of an antidiabetes herbal formula (ADHF) on the prevention of progressive diet‐induced type 2 diabetes (NIDDM) in the well recognized C57BL/6J mouse model were demonstrated. The results of the present studies confirm that C57BL/6J mice, through a genetic predisposition, developed NIDDM‐like symptoms on a regular schedule when fed solely on a diabetes induction diet containing high fat, high simple carbohydrate and low fibre. Blood glucose levels consistent with type 2 diabetes were detected after 8 weeks on this induction diet. In contrast, no members of the prevention study groups of C57BL/6J mice, which had ADHF mixed into their diabetes induction diet, developed progressive evidence of NIDDM‐like symptoms. 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subjects Animals
Biological and medical sciences
Blood Glucose - drug effects
Diabetes Mellitus, Experimental - prevention & control
Diabetes Mellitus, Type 2 - prevention & control
diabetes prevention
Diet
Dietary Fats - administration & dosage
Disease Models, Animal
General pharmacology
herbal formula
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Insulin - blood
Islets of Langerhans - drug effects
Islets of Langerhans - pathology
Liver - drug effects
Liver - pathology
Male
Medical sciences
Mice
Mice, Inbred C57BL
NIDDM
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal
Random Allocation
title Prevention of diet-induced type 2 diabetes in the C57BL/6J mouse model by an antidiabetic herbal formula
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