Cl− channel blockers inhibit transition of quiescent (G0) fibroblasts into the cell cycle

Modulation of ion permeability during the cell cycle is one of the key events in cell cycle progression. We have compared the effects of K+ and Cl− channel blockers on the cell cycle in synchronous and asynchronous NIH3T3 cells. The Cl− channel blocker 5‐N‐2‐(3‐phenylpropylamino) benzoic acid (NPPB;...

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Veröffentlicht in:	Journal of cellular physiology 2003-03, Vol.194 (3), p.376-383
Hauptverfasser:	Zheng, Ya-Juan, Furukawa, Tetsushi, Tajimi, Kimitaka, Inagaki, Nobuya
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 4-Aminopyridine - pharmacology Angiogenesis Inhibitors - pharmacology Animals Blood Proteins - pharmacology Cell Division - drug effects Chloride Channels - antagonists & inhibitors Fibroblasts - chemistry Fibroblasts - cytology Fibroblasts - metabolism G1 Phase - drug effects Iodine Radioisotopes Ki-67 Antigen - analysis Mice Nitrobenzoates - pharmacology Potassium Channel Blockers - pharmacology Resting Phase, Cell Cycle - drug effects S Phase - drug effects
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