Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane
A simple and rapid method was developed for the K + ions determination employing a flow injection system using a flow-through electrode based on the naturally-occurring antibiotic ionophore nonactin occluded in a polymeric membrane. The nonactin ionophore was trapped in poly(ethylene- co-vinyl aceta...
Gespeichert in:
| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2003-02, Vol.31 (1), p.11-18 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 18 |
|---|---|
| container_issue | 1 |
| container_start_page | 11 |
| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 31 |
| creator | Garcia, Carlos Alexandre Borges Júnior, Laércio Rover Neto, Graciliano de Oliveira |
| description | A simple and rapid method was developed for the K
+ ions determination employing a flow injection system using a flow-through electrode based on the naturally-occurring antibiotic ionophore nonactin occluded in a polymeric membrane. The nonactin ionophore was trapped in poly(ethylene-
co-vinyl acetate) (EVA) matrix (40% w/w in vinyl acetate) and dispersed on the surface of a graphite-epoxy tubular electrode. The plasticizer-free all-solid-state potassium-selective electrode showed a linear response for K
+ concentrations between 5.0×10
−5 and 5.0×10
−2 M (
r=0.9995) with a near-Nernstian slope of 51.5 mV per decade, when Tris–HCl buffer (pH 7.0;0,1 M) was employed as a carrier. The potentiometric-FIA system allows an analytical frequency of 120 samples per hour with a precision of 3.6%. The relative standard deviations (R.S.D.) for K
+ determination in pharmaceuticals samples, without any previous treatment, were lower than 4.0%, comparable to those obtained by flame photometry. Ammonium is the main analytical interference and the electrode response time was 5 s at 25
°C. The useful lifetime of the tubular sensor is longer than 3 months in continuous use. |
| doi_str_mv | 10.1016/S0731-7085(02)00598-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72981437</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0731708502005988</els_id><sourcerecordid>72981437</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-908aba06f125785465a7752a1cfcc92b4af2e8895efe5d6044ffa8a3644367673</originalsourceid><addsrcrecordid>eNqFkc1u1TAQhS1ERS-FRwB5A4JFip3YjrNCV6WllSp1wY_YWRNnTI3iOLUTpL4Iz4tv7xVdsrJlf3Nm5hxCXnF2yhlXH76wtuFVy7R8x-r3jMlOV_oJ2XDdNlWtxI-nZPMPOSbPc_7FCsU78Ywc81oqxoTYkD-fcMEU_ASLjxONjs5xgZz9Gmh5yNRPdL6FFMDiungLI80Q5hEz7e_pxdWWrtlPPyns6nAqIgGX5C3FEe2S4oC0h4wDLeJFL863MSGd4gR2KdLR2nEdyne5n3_f0oChTzDhC3LkYMz48nCekG8X51_PLqvrm89XZ9vrygrZLlXHNPTAlCsLtVoKJaFtZQ3cOmu7uhfgatS6k-hQDqps7BxoaJQQjWpV25yQt3vdOcW7FfNigs8Wx7HMENds2rrTXDQ7UO5Bm2LOCZ2Zkw-Q7g1nZheIeQjE7Nw2rDYPgRhd6l4fGqx9wOGx6pBAAd4cAMjFXVe2tz4_ckKrRjBZuI97Dosdvz0mk63HyeLgU3HaDNH_Z5S_LF-qOg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72981437</pqid></control><display><type>article</type><title>Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Garcia, Carlos Alexandre Borges ; Júnior, Laércio Rover ; Neto, Graciliano de Oliveira</creator><creatorcontrib>Garcia, Carlos Alexandre Borges ; Júnior, Laércio Rover ; Neto, Graciliano de Oliveira</creatorcontrib><description>A simple and rapid method was developed for the K
+ ions determination employing a flow injection system using a flow-through electrode based on the naturally-occurring antibiotic ionophore nonactin occluded in a polymeric membrane. The nonactin ionophore was trapped in poly(ethylene-
co-vinyl acetate) (EVA) matrix (40% w/w in vinyl acetate) and dispersed on the surface of a graphite-epoxy tubular electrode. The plasticizer-free all-solid-state potassium-selective electrode showed a linear response for K
+ concentrations between 5.0×10
−5 and 5.0×10
−2 M (
r=0.9995) with a near-Nernstian slope of 51.5 mV per decade, when Tris–HCl buffer (pH 7.0;0,1 M) was employed as a carrier. The potentiometric-FIA system allows an analytical frequency of 120 samples per hour with a precision of 3.6%. The relative standard deviations (R.S.D.) for K
+ determination in pharmaceuticals samples, without any previous treatment, were lower than 4.0%, comparable to those obtained by flame photometry. Ammonium is the main analytical interference and the electrode response time was 5 s at 25
°C. The useful lifetime of the tubular sensor is longer than 3 months in continuous use.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/S0731-7085(02)00598-8</identifier><identifier>PMID: 12560044</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Anti-Bacterial Agents - chemistry ; Biological and medical sciences ; Electrodes ; Flow Injection Analysis ; General pharmacology ; Hydrogen-Ion Concentration ; Indicators and Reagents ; Ionophores ; Macrolides - chemistry ; Medical sciences ; Membranes, Artificial ; Pharmaceutical samples ; Pharmacology. Drug treatments ; Polyvinyl Chloride ; Polyvinyls ; Potassium - analysis ; Potassium determination ; Potentiometric electrode ; Potentiometry ; Reference Standards ; Solvents</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2003-02, Vol.31 (1), p.11-18</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-908aba06f125785465a7752a1cfcc92b4af2e8895efe5d6044ffa8a3644367673</citedby><cites>FETCH-LOGICAL-c457t-908aba06f125785465a7752a1cfcc92b4af2e8895efe5d6044ffa8a3644367673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0731708502005988$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14863405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12560044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia, Carlos Alexandre Borges</creatorcontrib><creatorcontrib>Júnior, Laércio Rover</creatorcontrib><creatorcontrib>Neto, Graciliano de Oliveira</creatorcontrib><title>Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A simple and rapid method was developed for the K
+ ions determination employing a flow injection system using a flow-through electrode based on the naturally-occurring antibiotic ionophore nonactin occluded in a polymeric membrane. The nonactin ionophore was trapped in poly(ethylene-
co-vinyl acetate) (EVA) matrix (40% w/w in vinyl acetate) and dispersed on the surface of a graphite-epoxy tubular electrode. The plasticizer-free all-solid-state potassium-selective electrode showed a linear response for K
+ concentrations between 5.0×10
−5 and 5.0×10
−2 M (
r=0.9995) with a near-Nernstian slope of 51.5 mV per decade, when Tris–HCl buffer (pH 7.0;0,1 M) was employed as a carrier. The potentiometric-FIA system allows an analytical frequency of 120 samples per hour with a precision of 3.6%. The relative standard deviations (R.S.D.) for K
+ determination in pharmaceuticals samples, without any previous treatment, were lower than 4.0%, comparable to those obtained by flame photometry. Ammonium is the main analytical interference and the electrode response time was 5 s at 25
°C. The useful lifetime of the tubular sensor is longer than 3 months in continuous use.</description><subject>Analysis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Biological and medical sciences</subject><subject>Electrodes</subject><subject>Flow Injection Analysis</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Indicators and Reagents</subject><subject>Ionophores</subject><subject>Macrolides - chemistry</subject><subject>Medical sciences</subject><subject>Membranes, Artificial</subject><subject>Pharmaceutical samples</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyvinyl Chloride</subject><subject>Polyvinyls</subject><subject>Potassium - analysis</subject><subject>Potassium determination</subject><subject>Potentiometric electrode</subject><subject>Potentiometry</subject><subject>Reference Standards</subject><subject>Solvents</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS1ERS-FRwB5A4JFip3YjrNCV6WllSp1wY_YWRNnTI3iOLUTpL4Iz4tv7xVdsrJlf3Nm5hxCXnF2yhlXH76wtuFVy7R8x-r3jMlOV_oJ2XDdNlWtxI-nZPMPOSbPc_7FCsU78Ywc81oqxoTYkD-fcMEU_ASLjxONjs5xgZz9Gmh5yNRPdL6FFMDiungLI80Q5hEz7e_pxdWWrtlPPyns6nAqIgGX5C3FEe2S4oC0h4wDLeJFL863MSGd4gR2KdLR2nEdyne5n3_f0oChTzDhC3LkYMz48nCekG8X51_PLqvrm89XZ9vrygrZLlXHNPTAlCsLtVoKJaFtZQ3cOmu7uhfgatS6k-hQDqps7BxoaJQQjWpV25yQt3vdOcW7FfNigs8Wx7HMENds2rrTXDQ7UO5Bm2LOCZ2Zkw-Q7g1nZheIeQjE7Nw2rDYPgRhd6l4fGqx9wOGx6pBAAd4cAMjFXVe2tz4_ckKrRjBZuI97Dosdvz0mk63HyeLgU3HaDNH_Z5S_LF-qOg</recordid><startdate>20030205</startdate><enddate>20030205</enddate><creator>Garcia, Carlos Alexandre Borges</creator><creator>Júnior, Laércio Rover</creator><creator>Neto, Graciliano de Oliveira</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030205</creationdate><title>Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane</title><author>Garcia, Carlos Alexandre Borges ; Júnior, Laércio Rover ; Neto, Graciliano de Oliveira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-908aba06f125785465a7752a1cfcc92b4af2e8895efe5d6044ffa8a3644367673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Analysis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Biological and medical sciences</topic><topic>Electrodes</topic><topic>Flow Injection Analysis</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Indicators and Reagents</topic><topic>Ionophores</topic><topic>Macrolides - chemistry</topic><topic>Medical sciences</topic><topic>Membranes, Artificial</topic><topic>Pharmaceutical samples</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyvinyl Chloride</topic><topic>Polyvinyls</topic><topic>Potassium - analysis</topic><topic>Potassium determination</topic><topic>Potentiometric electrode</topic><topic>Potentiometry</topic><topic>Reference Standards</topic><topic>Solvents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia, Carlos Alexandre Borges</creatorcontrib><creatorcontrib>Júnior, Laércio Rover</creatorcontrib><creatorcontrib>Neto, Graciliano de Oliveira</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia, Carlos Alexandre Borges</au><au>Júnior, Laércio Rover</au><au>Neto, Graciliano de Oliveira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2003-02-05</date><risdate>2003</risdate><volume>31</volume><issue>1</issue><spage>11</spage><epage>18</epage><pages>11-18</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A simple and rapid method was developed for the K
+ ions determination employing a flow injection system using a flow-through electrode based on the naturally-occurring antibiotic ionophore nonactin occluded in a polymeric membrane. The nonactin ionophore was trapped in poly(ethylene-
co-vinyl acetate) (EVA) matrix (40% w/w in vinyl acetate) and dispersed on the surface of a graphite-epoxy tubular electrode. The plasticizer-free all-solid-state potassium-selective electrode showed a linear response for K
+ concentrations between 5.0×10
−5 and 5.0×10
−2 M (
r=0.9995) with a near-Nernstian slope of 51.5 mV per decade, when Tris–HCl buffer (pH 7.0;0,1 M) was employed as a carrier. The potentiometric-FIA system allows an analytical frequency of 120 samples per hour with a precision of 3.6%. The relative standard deviations (R.S.D.) for K
+ determination in pharmaceuticals samples, without any previous treatment, were lower than 4.0%, comparable to those obtained by flame photometry. Ammonium is the main analytical interference and the electrode response time was 5 s at 25
°C. The useful lifetime of the tubular sensor is longer than 3 months in continuous use.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12560044</pmid><doi>10.1016/S0731-7085(02)00598-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2003-02, Vol.31 (1), p.11-18 |
| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72981437 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Anti-Bacterial Agents - chemistry Biological and medical sciences Electrodes Flow Injection Analysis General pharmacology Hydrogen-Ion Concentration Indicators and Reagents Ionophores Macrolides - chemistry Medical sciences Membranes, Artificial Pharmaceutical samples Pharmacology. Drug treatments Polyvinyl Chloride Polyvinyls Potassium - analysis Potassium determination Potentiometric electrode Potentiometry Reference Standards Solvents |
| title | Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T22%3A41%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determination%20of%20potassium%20ions%20in%20pharmaceutical%20samples%20by%20FIA%20using%20a%20potentiometric%20electrode%20based%20on%20ionophore%20nonactin%20occluded%20in%20EVA%20membrane&rft.jtitle=Journal%20of%20pharmaceutical%20and%20biomedical%20analysis&rft.au=Garcia,%20Carlos%20Alexandre%20Borges&rft.date=2003-02-05&rft.volume=31&rft.issue=1&rft.spage=11&rft.epage=18&rft.pages=11-18&rft.issn=0731-7085&rft.eissn=1873-264X&rft.coden=JPBADA&rft_id=info:doi/10.1016/S0731-7085(02)00598-8&rft_dat=%3Cproquest_cross%3E72981437%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72981437&rft_id=info:pmid/12560044&rft_els_id=S0731708502005988&rfr_iscdi=true |