Transgenic Expression of RasGRP1 Induces the Maturation of Double-Negative Thymocytes and Enhances the Production of CD8 Single-Positive Thymocytes

RasGRP1 is a guanine nucleotide exchange factor for Ras that is required for the efficient production of both CD4 and CD8 single-positive thymocytes. We found that RasGRP1 expression is rapidly up-regulated in double-negative thymocytes following pre-TCR ligation. Transgenic overexpression of RasGRP...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-02, Vol.170 (3), p.1141-1149
Hauptverfasser:	Norment, Anne M, Bogatzki, Lisa Y, Klinger, Mark, Ojala, Ethan W, Bevan, Michael J, Kay, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - biosynthesis Adjuvants, Immunologic - genetics Adjuvants, Immunologic - physiology Amino Acid Sequence Animals CD8 Antigens - biosynthesis CD8 Antigens - genetics CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Cell Division - genetics Cell Division - immunology Crosses, Genetic DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Guanine Nucleotide Exchange Factors Humans Lymphocyte Count Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Mice, Transgenic Molecular Sequence Data Nuclear Proteins ras Proteins - physiology Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Receptors, Antigen, T-Cell - physiology T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymus Gland - cytology Thymus Gland - immunology Thymus Gland - metabolism Transgenes - immunology Up-Regulation - genetics Up-Regulation - immunology
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