Intraventricular administration of D-Ala2-Met5-enkephalinamide induces rapid recovery of responding for electrical brain stimulation from the ventral tegmental area following uncontrollable footshock
The effects of uncontrollable footshock were assessed in CD-1 mice responding for electrical brain stimulation (ICSS) from the dorsal aspects of the ventral tegmental area (VTA). Uncontrollable footshock provoked a marked reduction of responding for ICSS immediately, 24 h and 168 h following initial...
Gespeichert in:
| Veröffentlicht in: | Brain research bulletin 1992-02, Vol.28 (2), p.337-341 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 341 |
|---|---|
| container_issue | 2 |
| container_start_page | 337 |
| container_title | Brain research bulletin |
| container_volume | 28 |
| creator | MADDEAUX, C ZACHARKO, R. M |
| description | The effects of uncontrollable footshock were assessed in CD-1 mice responding for electrical brain stimulation (ICSS) from the dorsal aspects of the ventral tegmental area (VTA). Uncontrollable footshock provoked a marked reduction of responding for ICSS immediately, 24 h and 168 h following initial stressor exposure. Intraventricular administration of the neuropeptide, D-Ala2-Met5-enkephalinamide (DALA) (1 microgram/microliter delivered in a 1-microliter volume) following induction of reward alterations from the dorsal VTA provoked a rapid recovery of responding for ICSS in the immediate poststressor interval. This ameliorative effect of the neuropeptide deteriorated 24 h after initial exposure to uncontrollable footshock and was absent 1 week later. These data are discussed with respect to stressor-induced anhedonia in the mesocorticolimbic system. |
| doi_str_mv | 10.1016/0361-9230(92)90199-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72979420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72979420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c263t-8c1374c516173249b4b7ff597041c5ba494bfdf3ed53477fc4497834168ba01f3</originalsourceid><addsrcrecordid>eNpFUc2O1SAUJkYzXkffQBMWxugChQKlLCfj3yRj3Oi6ofQwF4dChXbMPKGvJb33ZtwcDnw_54QPoZeMvmeUtR8obxnRDadvdfNOU6Y16R6hHesUJ40S6jHaPVCeomel_KKUtp1sz9AZk7pVUu7Q36u4ZHMHtXq7BpOxGScffamvi08RJ4c_kotgGvINFkkg3sK8N8FHM_kRsI_jaqHgbGY_4gw23UG-31QZypzi6OMNdiljCGC3GSbgIRsfcVn8VAcehricJrzsAR8WqZQFbqba1s5kMNUghPRns1qjTZVS72YIUIG0lH2yt8_RE2dCgRen8xz9_Pzpx-VXcv39y9XlxTWxTcsX0lnGlbCStUzxRuhBDMo5qRUVzMrBCC0GNzoOo-RCKWeF0KrjgrXdYChz_By9OfrOOf1eoSz95IuFuk6EtJZeNVpp0dBKFEeizamUDK6fs59Mvu8Z7bf8-i2cfgunlv6QX99V2auT_zpMMP4XHQOr-OsTbkr9S5dNtL480CRVnVCC_wNQoqig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72979420</pqid></control><display><type>article</type><title>Intraventricular administration of D-Ala2-Met5-enkephalinamide induces rapid recovery of responding for electrical brain stimulation from the ventral tegmental area following uncontrollable footshock</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>MADDEAUX, C ; ZACHARKO, R. M</creator><creatorcontrib>MADDEAUX, C ; ZACHARKO, R. M</creatorcontrib><description>The effects of uncontrollable footshock were assessed in CD-1 mice responding for electrical brain stimulation (ICSS) from the dorsal aspects of the ventral tegmental area (VTA). Uncontrollable footshock provoked a marked reduction of responding for ICSS immediately, 24 h and 168 h following initial stressor exposure. Intraventricular administration of the neuropeptide, D-Ala2-Met5-enkephalinamide (DALA) (1 microgram/microliter delivered in a 1-microliter volume) following induction of reward alterations from the dorsal VTA provoked a rapid recovery of responding for ICSS in the immediate poststressor interval. This ameliorative effect of the neuropeptide deteriorated 24 h after initial exposure to uncontrollable footshock and was absent 1 week later. These data are discussed with respect to stressor-induced anhedonia in the mesocorticolimbic system.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(92)90199-8</identifier><identifier>PMID: 1596755</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - physiology ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cerebral Ventricles - drug effects ; Cerebral Ventricles - physiology ; Electric Stimulation ; Electroshock ; Enkephalin, Methionine - administration & dosage ; Enkephalin, Methionine - analogs & derivatives ; Enkephalin, Methionine - pharmacology ; Foot - innervation ; Fundamental and applied biological sciences. Psychology ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred Strains ; Tegmentum Mesencephali - physiology ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research bulletin, 1992-02, Vol.28 (2), p.337-341</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c263t-8c1374c516173249b4b7ff597041c5ba494bfdf3ed53477fc4497834168ba01f3</citedby><cites>FETCH-LOGICAL-c263t-8c1374c516173249b4b7ff597041c5ba494bfdf3ed53477fc4497834168ba01f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5078474$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1596755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MADDEAUX, C</creatorcontrib><creatorcontrib>ZACHARKO, R. M</creatorcontrib><title>Intraventricular administration of D-Ala2-Met5-enkephalinamide induces rapid recovery of responding for electrical brain stimulation from the ventral tegmental area following uncontrollable footshock</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>The effects of uncontrollable footshock were assessed in CD-1 mice responding for electrical brain stimulation (ICSS) from the dorsal aspects of the ventral tegmental area (VTA). Uncontrollable footshock provoked a marked reduction of responding for ICSS immediately, 24 h and 168 h following initial stressor exposure. Intraventricular administration of the neuropeptide, D-Ala2-Met5-enkephalinamide (DALA) (1 microgram/microliter delivered in a 1-microliter volume) following induction of reward alterations from the dorsal VTA provoked a rapid recovery of responding for ICSS in the immediate poststressor interval. This ameliorative effect of the neuropeptide deteriorated 24 h after initial exposure to uncontrollable footshock and was absent 1 week later. These data are discussed with respect to stressor-induced anhedonia in the mesocorticolimbic system.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cerebral Ventricles - drug effects</subject><subject>Cerebral Ventricles - physiology</subject><subject>Electric Stimulation</subject><subject>Electroshock</subject><subject>Enkephalin, Methionine - administration & dosage</subject><subject>Enkephalin, Methionine - analogs & derivatives</subject><subject>Enkephalin, Methionine - pharmacology</subject><subject>Foot - innervation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Tegmentum Mesencephali - physiology</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUc2O1SAUJkYzXkffQBMWxugChQKlLCfj3yRj3Oi6ofQwF4dChXbMPKGvJb33ZtwcDnw_54QPoZeMvmeUtR8obxnRDadvdfNOU6Y16R6hHesUJ40S6jHaPVCeomel_KKUtp1sz9AZk7pVUu7Q36u4ZHMHtXq7BpOxGScffamvi08RJ4c_kotgGvINFkkg3sK8N8FHM_kRsI_jaqHgbGY_4gw23UG-31QZypzi6OMNdiljCGC3GSbgIRsfcVn8VAcehricJrzsAR8WqZQFbqba1s5kMNUghPRns1qjTZVS72YIUIG0lH2yt8_RE2dCgRen8xz9_Pzpx-VXcv39y9XlxTWxTcsX0lnGlbCStUzxRuhBDMo5qRUVzMrBCC0GNzoOo-RCKWeF0KrjgrXdYChz_By9OfrOOf1eoSz95IuFuk6EtJZeNVpp0dBKFEeizamUDK6fs59Mvu8Z7bf8-i2cfgunlv6QX99V2auT_zpMMP4XHQOr-OsTbkr9S5dNtL480CRVnVCC_wNQoqig</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>MADDEAUX, C</creator><creator>ZACHARKO, R. M</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920201</creationdate><title>Intraventricular administration of D-Ala2-Met5-enkephalinamide induces rapid recovery of responding for electrical brain stimulation from the ventral tegmental area following uncontrollable footshock</title><author>MADDEAUX, C ; ZACHARKO, R. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c263t-8c1374c516173249b4b7ff597041c5ba494bfdf3ed53477fc4497834168ba01f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Cerebral Ventricles - drug effects</topic><topic>Cerebral Ventricles - physiology</topic><topic>Electric Stimulation</topic><topic>Electroshock</topic><topic>Enkephalin, Methionine - administration & dosage</topic><topic>Enkephalin, Methionine - analogs & derivatives</topic><topic>Enkephalin, Methionine - pharmacology</topic><topic>Foot - innervation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Tegmentum Mesencephali - physiology</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MADDEAUX, C</creatorcontrib><creatorcontrib>ZACHARKO, R. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MADDEAUX, C</au><au>ZACHARKO, R. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraventricular administration of D-Ala2-Met5-enkephalinamide induces rapid recovery of responding for electrical brain stimulation from the ventral tegmental area following uncontrollable footshock</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>28</volume><issue>2</issue><spage>337</spage><epage>341</epage><pages>337-341</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>The effects of uncontrollable footshock were assessed in CD-1 mice responding for electrical brain stimulation (ICSS) from the dorsal aspects of the ventral tegmental area (VTA). Uncontrollable footshock provoked a marked reduction of responding for ICSS immediately, 24 h and 168 h following initial stressor exposure. Intraventricular administration of the neuropeptide, D-Ala2-Met5-enkephalinamide (DALA) (1 microgram/microliter delivered in a 1-microliter volume) following induction of reward alterations from the dorsal VTA provoked a rapid recovery of responding for ICSS in the immediate poststressor interval. This ameliorative effect of the neuropeptide deteriorated 24 h after initial exposure to uncontrollable footshock and was absent 1 week later. These data are discussed with respect to stressor-induced anhedonia in the mesocorticolimbic system.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>1596755</pmid><doi>10.1016/0361-9230(92)90199-8</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 1992-02, Vol.28 (2), p.337-341 |
| issn | 0361-9230 1873-2747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72979420 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Brain - drug effects Brain - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Ventricles - drug effects Cerebral Ventricles - physiology Electric Stimulation Electroshock Enkephalin, Methionine - administration & dosage Enkephalin, Methionine - analogs & derivatives Enkephalin, Methionine - pharmacology Foot - innervation Fundamental and applied biological sciences. Psychology Injections, Intraventricular Male Mice Mice, Inbred Strains Tegmentum Mesencephali - physiology Time Factors Vertebrates: nervous system and sense organs |
| title | Intraventricular administration of D-Ala2-Met5-enkephalinamide induces rapid recovery of responding for electrical brain stimulation from the ventral tegmental area following uncontrollable footshock |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T16%3A25%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intraventricular%20administration%20of%20D-Ala2-Met5-enkephalinamide%20induces%20rapid%20recovery%20of%20responding%20for%20electrical%20brain%20stimulation%20from%20the%20ventral%20tegmental%20area%20following%20uncontrollable%20footshock&rft.jtitle=Brain%20research%20bulletin&rft.au=MADDEAUX,%20C&rft.date=1992-02-01&rft.volume=28&rft.issue=2&rft.spage=337&rft.epage=341&rft.pages=337-341&rft.issn=0361-9230&rft.eissn=1873-2747&rft.coden=BRBUDU&rft_id=info:doi/10.1016/0361-9230(92)90199-8&rft_dat=%3Cproquest_cross%3E72979420%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72979420&rft_id=info:pmid/1596755&rfr_iscdi=true |