Stromal factors involved in prostate carcinoma metastasis to bone
BACKGROUND Prostate carcinoma (PC) frequently metastasizes to bone, where it causes significant morbidity and mortality. Stromal elements in the primary and metastatic target organs are important mediators of tumor cell intravasation, chemoattraction, adhesion to target organ microvascular endotheli...
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| Veröffentlicht in: | Cancer 2003-02, Vol.97 (S3), p.739-747 |
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| creator | Cooper, Carlton R. Chay, Christopher H. Gendernalik, James D. Lee, Hyung‐Lae Bhatia, Jasmine Taichman, Russell S. McCauley, Laurie K. Keller, Evan T. Pienta, Kenneth J. |
| description | BACKGROUND
Prostate carcinoma (PC) frequently metastasizes to bone, where it causes significant morbidity and mortality. Stromal elements in the primary and metastatic target organs are important mediators of tumor cell intravasation, chemoattraction, adhesion to target organ microvascular endothelium, extravasation, and growth at the metastatic site.
METHODS
The role of stromal factors in bone metastasis was determined with a cyclic DNA microarray comparison of a bone‐derived cell PC cell line with a soft tissue‐derived cell PC cell line and by evaluating the effects of selected stromal components on PC cell chemotaxis, cell adhesion to human bone marrow endothelium (HBME), and PC cell growth.
RESULTS
The authors demonstrate that PC cells express protease‐activated receptor 1 (PAR1; thrombin receptor), and its expression is up‐regulated in PC compared with normal prostate tissue. In addition, this overexpression was very pronounced in bone‐derived PC cell lines (VCaP and PC‐3) compared with soft tissue PC cell lines (DUCaP, DU145, and LNCaP). The authors report that bone stromal factors, including stromal cell‐derived factor 1 (SDF‐1) and collagen Type I peptides, are chemoattractants for PC cells, and they demonstrate that some of these factors (e.g., extracellular matrix components, transforming growth factor β, bone morphogenic proteins [BMPs], and SDF‐1) significantly alter PC‐HBME interaction in vitro. Finally, stromal factors, such as BMPs, can regulate the proliferation of PC cells in vitro.
CONCLUSIONS
Soluble and insoluble elements of the stroma are involved in multiple steps of PC metastasis to bone. The authors hypothesize that PAR1 may play a central role in prostate tumorigenesis. Cancer 2003;97(3 Suppl):739–47. © 2003 American Cancer Society.
DOI 10.1002/cncr.11181
The authors present data supporting the role of stromal factors in the metastasis of prostate carcinoma to bone marrow. Stromal factors can regulate local tumor cell invasion, act as chemoattractants, modulate tumor cell adhesion to bone marrow endothelium, facilitate extravasation, and regulate tumor cell growth in the bone microenvironment. |
| doi_str_mv | 10.1002/cncr.11181 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72979055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72979055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4571-fd5972ef47101a1add11f09dba94697eaea0c19a631305a790891b311b1e0f4c3</originalsourceid><addsrcrecordid>eNp90EtLxDAQB_AgiruuXvwA0osehK6ZNmmaoxRfsCj4AG9hmiZQ6WNNuiv77c3ahb15SjL8MjP8CTkHOgdKkxvdaTcHgBwOyBSoFDEFlhySKaU0jzlLPyfkxPuv8BQJT4_JBBLOci5gSm7fBte32EQW9dA7H9Xdum_WpgqXaOl6P-BgIo1O111wUWsGDDVf-2joo7LvzCk5sth4c7Y7Z-Tj_u69eIwXLw9Pxe0i1ixMim3FpUiMZQIoIGBVAVgqqxIly6QwaJBqkJilkFKOQtJcQpkClGCoZTqdkauxb9jqe2X8oNraa9M02Jl-5ZVIZPjEeYDXI9Rhfe-MVUtXt-g2CqjaBqa2gam_wAK-2HVdla2p9nSXUACXO4BeY2Mddrr2e8d4mmQZCw5G91M3ZvPPSFU8F6_j8F-JeoJ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72979055</pqid></control><display><type>article</type><title>Stromal factors involved in prostate carcinoma metastasis to bone</title><source>MEDLINE</source><source>Wiley-Blackwell Full Collection</source><source>Wiley-Blackwell Free Backfiles(OpenAccess)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Cooper, Carlton R. ; Chay, Christopher H. ; Gendernalik, James D. ; Lee, Hyung‐Lae ; Bhatia, Jasmine ; Taichman, Russell S. ; McCauley, Laurie K. ; Keller, Evan T. ; Pienta, Kenneth J.</creator><creatorcontrib>Cooper, Carlton R. ; Chay, Christopher H. ; Gendernalik, James D. ; Lee, Hyung‐Lae ; Bhatia, Jasmine ; Taichman, Russell S. ; McCauley, Laurie K. ; Keller, Evan T. ; Pienta, Kenneth J.</creatorcontrib><description>BACKGROUND
Prostate carcinoma (PC) frequently metastasizes to bone, where it causes significant morbidity and mortality. Stromal elements in the primary and metastatic target organs are important mediators of tumor cell intravasation, chemoattraction, adhesion to target organ microvascular endothelium, extravasation, and growth at the metastatic site.
METHODS
The role of stromal factors in bone metastasis was determined with a cyclic DNA microarray comparison of a bone‐derived cell PC cell line with a soft tissue‐derived cell PC cell line and by evaluating the effects of selected stromal components on PC cell chemotaxis, cell adhesion to human bone marrow endothelium (HBME), and PC cell growth.
RESULTS
The authors demonstrate that PC cells express protease‐activated receptor 1 (PAR1; thrombin receptor), and its expression is up‐regulated in PC compared with normal prostate tissue. In addition, this overexpression was very pronounced in bone‐derived PC cell lines (VCaP and PC‐3) compared with soft tissue PC cell lines (DUCaP, DU145, and LNCaP). The authors report that bone stromal factors, including stromal cell‐derived factor 1 (SDF‐1) and collagen Type I peptides, are chemoattractants for PC cells, and they demonstrate that some of these factors (e.g., extracellular matrix components, transforming growth factor β, bone morphogenic proteins [BMPs], and SDF‐1) significantly alter PC‐HBME interaction in vitro. Finally, stromal factors, such as BMPs, can regulate the proliferation of PC cells in vitro.
CONCLUSIONS
Soluble and insoluble elements of the stroma are involved in multiple steps of PC metastasis to bone. The authors hypothesize that PAR1 may play a central role in prostate tumorigenesis. Cancer 2003;97(3 Suppl):739–47. © 2003 American Cancer Society.
DOI 10.1002/cncr.11181
The authors present data supporting the role of stromal factors in the metastasis of prostate carcinoma to bone marrow. Stromal factors can regulate local tumor cell invasion, act as chemoattractants, modulate tumor cell adhesion to bone marrow endothelium, facilitate extravasation, and regulate tumor cell growth in the bone microenvironment.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.11181</identifier><identifier>PMID: 12548571</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; bone metastasis ; Bone Morphogenetic Proteins - metabolism ; Bone Neoplasms - metabolism ; Bone Neoplasms - pathology ; Bone Neoplasms - secondary ; Cell Adhesion ; Cell Communication ; chemotactic factors ; cytokines ; Diseases of the osteoarticular system ; Endothelium - physiology ; Humans ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; prostate carcinoma ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - physiopathology ; Receptor, PAR-1 ; Receptors, Thrombin - metabolism ; Stromal Cells - physiology ; thrombin ; Tumors of striated muscle and skeleton ; Tumors of the urinary system ; Up-Regulation ; Urinary tract. Prostate gland</subject><ispartof>Cancer, 2003-02, Vol.97 (S3), p.739-747</ispartof><rights>Copyright © 2003 American Cancer Society</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11181</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4571-fd5972ef47101a1add11f09dba94697eaea0c19a631305a790891b311b1e0f4c3</citedby><cites>FETCH-LOGICAL-c4571-fd5972ef47101a1add11f09dba94697eaea0c19a631305a790891b311b1e0f4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.11181$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.11181$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,1433,23930,23931,25140,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14532664$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12548571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooper, Carlton R.</creatorcontrib><creatorcontrib>Chay, Christopher H.</creatorcontrib><creatorcontrib>Gendernalik, James D.</creatorcontrib><creatorcontrib>Lee, Hyung‐Lae</creatorcontrib><creatorcontrib>Bhatia, Jasmine</creatorcontrib><creatorcontrib>Taichman, Russell S.</creatorcontrib><creatorcontrib>McCauley, Laurie K.</creatorcontrib><creatorcontrib>Keller, Evan T.</creatorcontrib><creatorcontrib>Pienta, Kenneth J.</creatorcontrib><title>Stromal factors involved in prostate carcinoma metastasis to bone</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Prostate carcinoma (PC) frequently metastasizes to bone, where it causes significant morbidity and mortality. Stromal elements in the primary and metastatic target organs are important mediators of tumor cell intravasation, chemoattraction, adhesion to target organ microvascular endothelium, extravasation, and growth at the metastatic site.
METHODS
The role of stromal factors in bone metastasis was determined with a cyclic DNA microarray comparison of a bone‐derived cell PC cell line with a soft tissue‐derived cell PC cell line and by evaluating the effects of selected stromal components on PC cell chemotaxis, cell adhesion to human bone marrow endothelium (HBME), and PC cell growth.
RESULTS
The authors demonstrate that PC cells express protease‐activated receptor 1 (PAR1; thrombin receptor), and its expression is up‐regulated in PC compared with normal prostate tissue. In addition, this overexpression was very pronounced in bone‐derived PC cell lines (VCaP and PC‐3) compared with soft tissue PC cell lines (DUCaP, DU145, and LNCaP). The authors report that bone stromal factors, including stromal cell‐derived factor 1 (SDF‐1) and collagen Type I peptides, are chemoattractants for PC cells, and they demonstrate that some of these factors (e.g., extracellular matrix components, transforming growth factor β, bone morphogenic proteins [BMPs], and SDF‐1) significantly alter PC‐HBME interaction in vitro. Finally, stromal factors, such as BMPs, can regulate the proliferation of PC cells in vitro.
CONCLUSIONS
Soluble and insoluble elements of the stroma are involved in multiple steps of PC metastasis to bone. The authors hypothesize that PAR1 may play a central role in prostate tumorigenesis. Cancer 2003;97(3 Suppl):739–47. © 2003 American Cancer Society.
DOI 10.1002/cncr.11181
The authors present data supporting the role of stromal factors in the metastasis of prostate carcinoma to bone marrow. Stromal factors can regulate local tumor cell invasion, act as chemoattractants, modulate tumor cell adhesion to bone marrow endothelium, facilitate extravasation, and regulate tumor cell growth in the bone microenvironment.</description><subject>Biological and medical sciences</subject><subject>bone metastasis</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - secondary</subject><subject>Cell Adhesion</subject><subject>Cell Communication</subject><subject>chemotactic factors</subject><subject>cytokines</subject><subject>Diseases of the osteoarticular system</subject><subject>Endothelium - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>prostate carcinoma</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - physiopathology</subject><subject>Receptor, PAR-1</subject><subject>Receptors, Thrombin - metabolism</subject><subject>Stromal Cells - physiology</subject><subject>thrombin</subject><subject>Tumors of striated muscle and skeleton</subject><subject>Tumors of the urinary system</subject><subject>Up-Regulation</subject><subject>Urinary tract. Prostate gland</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90EtLxDAQB_AgiruuXvwA0osehK6ZNmmaoxRfsCj4AG9hmiZQ6WNNuiv77c3ahb15SjL8MjP8CTkHOgdKkxvdaTcHgBwOyBSoFDEFlhySKaU0jzlLPyfkxPuv8BQJT4_JBBLOci5gSm7fBte32EQW9dA7H9Xdum_WpgqXaOl6P-BgIo1O111wUWsGDDVf-2joo7LvzCk5sth4c7Y7Z-Tj_u69eIwXLw9Pxe0i1ixMim3FpUiMZQIoIGBVAVgqqxIly6QwaJBqkJilkFKOQtJcQpkClGCoZTqdkauxb9jqe2X8oNraa9M02Jl-5ZVIZPjEeYDXI9Rhfe-MVUtXt-g2CqjaBqa2gam_wAK-2HVdla2p9nSXUACXO4BeY2Mddrr2e8d4mmQZCw5G91M3ZvPPSFU8F6_j8F-JeoJ4</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Cooper, Carlton R.</creator><creator>Chay, Christopher H.</creator><creator>Gendernalik, James D.</creator><creator>Lee, Hyung‐Lae</creator><creator>Bhatia, Jasmine</creator><creator>Taichman, Russell S.</creator><creator>McCauley, Laurie K.</creator><creator>Keller, Evan T.</creator><creator>Pienta, Kenneth J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Stromal factors involved in prostate carcinoma metastasis to bone</title><author>Cooper, Carlton R. ; Chay, Christopher H. ; Gendernalik, James D. ; Lee, Hyung‐Lae ; Bhatia, Jasmine ; Taichman, Russell S. ; McCauley, Laurie K. ; Keller, Evan T. ; Pienta, Kenneth J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4571-fd5972ef47101a1add11f09dba94697eaea0c19a631305a790891b311b1e0f4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>bone metastasis</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - secondary</topic><topic>Cell Adhesion</topic><topic>Cell Communication</topic><topic>chemotactic factors</topic><topic>cytokines</topic><topic>Diseases of the osteoarticular system</topic><topic>Endothelium - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>prostate carcinoma</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - physiopathology</topic><topic>Receptor, PAR-1</topic><topic>Receptors, Thrombin - metabolism</topic><topic>Stromal Cells - physiology</topic><topic>thrombin</topic><topic>Tumors of striated muscle and skeleton</topic><topic>Tumors of the urinary system</topic><topic>Up-Regulation</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooper, Carlton R.</creatorcontrib><creatorcontrib>Chay, Christopher H.</creatorcontrib><creatorcontrib>Gendernalik, James D.</creatorcontrib><creatorcontrib>Lee, Hyung‐Lae</creatorcontrib><creatorcontrib>Bhatia, Jasmine</creatorcontrib><creatorcontrib>Taichman, Russell S.</creatorcontrib><creatorcontrib>McCauley, Laurie K.</creatorcontrib><creatorcontrib>Keller, Evan T.</creatorcontrib><creatorcontrib>Pienta, Kenneth J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooper, Carlton R.</au><au>Chay, Christopher H.</au><au>Gendernalik, James D.</au><au>Lee, Hyung‐Lae</au><au>Bhatia, Jasmine</au><au>Taichman, Russell S.</au><au>McCauley, Laurie K.</au><au>Keller, Evan T.</au><au>Pienta, Kenneth J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stromal factors involved in prostate carcinoma metastasis to bone</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>97</volume><issue>S3</issue><spage>739</spage><epage>747</epage><pages>739-747</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Prostate carcinoma (PC) frequently metastasizes to bone, where it causes significant morbidity and mortality. Stromal elements in the primary and metastatic target organs are important mediators of tumor cell intravasation, chemoattraction, adhesion to target organ microvascular endothelium, extravasation, and growth at the metastatic site.
METHODS
The role of stromal factors in bone metastasis was determined with a cyclic DNA microarray comparison of a bone‐derived cell PC cell line with a soft tissue‐derived cell PC cell line and by evaluating the effects of selected stromal components on PC cell chemotaxis, cell adhesion to human bone marrow endothelium (HBME), and PC cell growth.
RESULTS
The authors demonstrate that PC cells express protease‐activated receptor 1 (PAR1; thrombin receptor), and its expression is up‐regulated in PC compared with normal prostate tissue. In addition, this overexpression was very pronounced in bone‐derived PC cell lines (VCaP and PC‐3) compared with soft tissue PC cell lines (DUCaP, DU145, and LNCaP). The authors report that bone stromal factors, including stromal cell‐derived factor 1 (SDF‐1) and collagen Type I peptides, are chemoattractants for PC cells, and they demonstrate that some of these factors (e.g., extracellular matrix components, transforming growth factor β, bone morphogenic proteins [BMPs], and SDF‐1) significantly alter PC‐HBME interaction in vitro. Finally, stromal factors, such as BMPs, can regulate the proliferation of PC cells in vitro.
CONCLUSIONS
Soluble and insoluble elements of the stroma are involved in multiple steps of PC metastasis to bone. The authors hypothesize that PAR1 may play a central role in prostate tumorigenesis. Cancer 2003;97(3 Suppl):739–47. © 2003 American Cancer Society.
DOI 10.1002/cncr.11181
The authors present data supporting the role of stromal factors in the metastasis of prostate carcinoma to bone marrow. Stromal factors can regulate local tumor cell invasion, act as chemoattractants, modulate tumor cell adhesion to bone marrow endothelium, facilitate extravasation, and regulate tumor cell growth in the bone microenvironment.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12548571</pmid><doi>10.1002/cncr.11181</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences bone metastasis Bone Morphogenetic Proteins - metabolism Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - secondary Cell Adhesion Cell Communication chemotactic factors cytokines Diseases of the osteoarticular system Endothelium - physiology Humans Male Medical sciences Nephrology. Urinary tract diseases prostate carcinoma Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - physiopathology Receptor, PAR-1 Receptors, Thrombin - metabolism Stromal Cells - physiology thrombin Tumors of striated muscle and skeleton Tumors of the urinary system Up-Regulation Urinary tract. Prostate gland |
| title | Stromal factors involved in prostate carcinoma metastasis to bone |
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