Autoimmunoreactivity to Schwann cells in patients with inflammatory neuropathies

Inflammatory demyelinating neuropathies are characterized by a loss of peripheral nerve myelin. Myelin breakdown is thought to result from an autoimmune reaction towards nerve components. Schwann cells play a crucial role in the synthesis and maintenance of peripheral nerve myelin. An immune attack...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2003-02, Vol.126 (2), p.361-375
Hauptverfasser:	Kwa, Marcel S. G., van Schaik, Ivo N., De Jonge, Rosalein R., Brand, Anneke, Kalaydjieva, Luba, van Belzen, Nico, Vermeulen, Marinus, Baas, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Autoantibodies - blood autoantibody Autoimmunity Biological and medical sciences Cell Culture Techniques - methods Child CIDP = chronic inflammatory demyelinating polyneuropathy Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Epitopes - immunology Female GBS = Guillain–Barré syndrome GFAP = glial fibrillary acidic protein Guillain-Barre Syndrome - immunology Guillain–Barré HMSN = hereditary sensory and motor neuropathy Humans IF = immunofluorescence IgG = immunoglobulin G Immune Sera - immunology Immunoglobulin G - blood IVIg = intravenous immunoglobulins MAb = monoclonal antibody Male Medical sciences Microscopy, Fluorescence Middle Aged Myelin Sheath - immunology NDRG = N‐myc downstream‐regulated gene nerve Nerve Fibers - immunology Nerve Tissue Proteins - immunology Nervous system (semeiology, syndromes) Neurology neuropathy PAb = polyclonal antibody PBS = phosphate‐buffered saline PFA = paraformaldehyde Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - immunology Schwann Schwann Cells - immunology SMA = smooth muscle actin Tropical medicine
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