Differentiation and Apoptosis in Human Immortalized Sebocytes

Increased cell volume, accumulation of lipid droplets in the cytoplasm, and nuclear degeneration are phenomena indicating terminal differentiation of human sebocytes followed by holocrine secretion and cell death. The molecular pathways of natural and induced sebocyte elimination are still unknown,...

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Veröffentlicht in:	Journal of investigative dermatology 2003-02, Vol.120 (2), p.175-181
Hauptverfasser:	Wróbel, Anna, Seltmann, Holger, Fimmel, Sabine, Müller-Decker, Karin, Tsukada, Miki, Bogdanoff, Birgit, Mandt, Nathalie, Blume-Peytavi, Ulrike, Orfanos, Constantin E., Zouboulis, Christos C.
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Arachidonic Acid - pharmacology bcl-2-Associated X Protein Biological and medical sciences Caspase 3 Caspases - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology cell line Cell Line, Transformed Dermatology differentiation Dihydrotestosterone - pharmacology DNA Fragmentation - drug effects DNA Fragmentation - physiology Enzyme Inhibitors - pharmacology Gene Expression Humans Investigative techniques, diagnostic techniques (general aspects) Isotretinoin - pharmacology L-Lactate Dehydrogenase - metabolism Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphatidylserines - metabolism Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 - analysis Proto-Oncogene Proteins c-bcl-2 - genetics retinoids RNA, Messenger - analysis sebaceous gland Sebaceous Glands - chemistry Sebaceous Glands - cytology Sebaceous Glands - physiology Staurosporine - pharmacology
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