Acute blindness as a presenting sign in childhood Non-Hodgkin lymphoma
Non-Hodgkin lymphoma is the third most common malignancy in childhood. Occasionally, a patient with lymphoma may present with neuroophthalmologic symptoms and signs. It is usually associated with 3rd, 4th, and 6th cranial nerve palsies. Here, we report three children presenting with loss of vision....
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2003, Vol.25 (1), p.69-72 |
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| container_title | Journal of pediatric hematology/oncology |
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| creator | GÜLER, Elif KUTLUK, Tezer AKALAN, Nejat AKYÜZ, Canan ATAHAN, Lale BÜYÜKPAMUKCU, Münevver |
| description | Non-Hodgkin lymphoma is the third most common malignancy in childhood. Occasionally, a patient with lymphoma may present with neuroophthalmologic symptoms and signs. It is usually associated with 3rd, 4th, and 6th cranial nerve palsies. Here, we report three children presenting with loss of vision. Two of them were cured with modified LMB-89 (lymphoma malignant B) chemotherapy regimen and radiotherapy. In one patient, loss of vision returned to normal in the left eye but persisted in the right eye. The second patient suffered from permanent visual loss, although the primary disease responded well to treatment. Unfortunately, the third patient died at an early phase of treatment. Acute blindness as a presenting symptom is rare in lymphoma. Early diagnosis and treatment is critical to increase the survival rate and to improve the quality of the vision. |
| doi_str_mv | 10.1097/00043426-200301000-00014 |
| format | Article |
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Occasionally, a patient with lymphoma may present with neuroophthalmologic symptoms and signs. It is usually associated with 3rd, 4th, and 6th cranial nerve palsies. Here, we report three children presenting with loss of vision. Two of them were cured with modified LMB-89 (lymphoma malignant B) chemotherapy regimen and radiotherapy. In one patient, loss of vision returned to normal in the left eye but persisted in the right eye. The second patient suffered from permanent visual loss, although the primary disease responded well to treatment. Unfortunately, the third patient died at an early phase of treatment. Acute blindness as a presenting symptom is rare in lymphoma. Early diagnosis and treatment is critical to increase the survival rate and to improve the quality of the vision.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/00043426-200301000-00014</identifier><identifier>PMID: 12544777</identifier><identifier>CODEN: JPHOFG</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Acute Disease ; Adolescent ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Blindness - diagnosis ; Blindness - etiology ; Blindness - therapy ; Child ; Child, Preschool ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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Occasionally, a patient with lymphoma may present with neuroophthalmologic symptoms and signs. It is usually associated with 3rd, 4th, and 6th cranial nerve palsies. Here, we report three children presenting with loss of vision. Two of them were cured with modified LMB-89 (lymphoma malignant B) chemotherapy regimen and radiotherapy. In one patient, loss of vision returned to normal in the left eye but persisted in the right eye. The second patient suffered from permanent visual loss, although the primary disease responded well to treatment. Unfortunately, the third patient died at an early phase of treatment. Acute blindness as a presenting symptom is rare in lymphoma. Early diagnosis and treatment is critical to increase the survival rate and to improve the quality of the vision.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blindness - diagnosis</subject><subject>Blindness - etiology</subject><subject>Blindness - therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Non-Hodgkin - complications</subject><subject>Lymphoma, Non-Hodgkin - diagnosis</subject><subject>Lymphoma, Non-Hodgkin - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Radiotherapy, Adjuvant</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1PwyAUhonRuDn9C4Ybvavy1dJeLotzJove6DWhcLqhLa2lvdi_F7W6hBM45HkP4UEIU3JHSSHvCSGCC5YljBBOaGyTWFScoDlNeZbwTOan8UykTASlYoYuQniPhIypczSjLBVCSjlH66UZB8Bl7bz1EALWceGuhwB-cH6Hg9t57Dw2e1fbfdta_Nz6ZNPa3Ue8rQ9Nt28bfYnOKl0HuJr2BXpbP7yuNsn25fFptdwmhhd0SHQJlIFgnKTWZizNdGnLimlri1LmAMQKAqbIGTEWCkoZKQsAWqZ5XhlDDV-g29-5Xd9-jhAG1bhgoK61h3YMSrIifisnEcx_QdO3IfRQqa53je4PihL17VD9OVT_DtWPwxi9nt4YywbsMThJi8DNBOhgdF312hsXjpwQWRRf8C9RZHnB</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>GÜLER, Elif</creator><creator>KUTLUK, Tezer</creator><creator>AKALAN, Nejat</creator><creator>AKYÜZ, Canan</creator><creator>ATAHAN, Lale</creator><creator>BÜYÜKPAMUKCU, Münevver</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Acute blindness as a presenting sign in childhood Non-Hodgkin lymphoma</title><author>GÜLER, Elif ; KUTLUK, Tezer ; AKALAN, Nejat ; AKYÜZ, Canan ; ATAHAN, Lale ; BÜYÜKPAMUKCU, Münevver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-abe12e42305dd6256abdbf2add9b78ee0d40ec9820cde91120b9ee1b588fcc1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blindness - diagnosis</topic><topic>Blindness - etiology</topic><topic>Blindness - therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Non-Hodgkin - complications</topic><topic>Lymphoma, Non-Hodgkin - diagnosis</topic><topic>Lymphoma, Non-Hodgkin - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Radiotherapy, Adjuvant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GÜLER, Elif</creatorcontrib><creatorcontrib>KUTLUK, Tezer</creatorcontrib><creatorcontrib>AKALAN, Nejat</creatorcontrib><creatorcontrib>AKYÜZ, Canan</creatorcontrib><creatorcontrib>ATAHAN, Lale</creatorcontrib><creatorcontrib>BÜYÜKPAMUKCU, Münevver</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GÜLER, Elif</au><au>KUTLUK, Tezer</au><au>AKALAN, Nejat</au><au>AKYÜZ, Canan</au><au>ATAHAN, Lale</au><au>BÜYÜKPAMUKCU, Münevver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute blindness as a presenting sign in childhood Non-Hodgkin lymphoma</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2003</date><risdate>2003</risdate><volume>25</volume><issue>1</issue><spage>69</spage><epage>72</epage><pages>69-72</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><coden>JPHOFG</coden><abstract>Non-Hodgkin lymphoma is the third most common malignancy in childhood. Occasionally, a patient with lymphoma may present with neuroophthalmologic symptoms and signs. It is usually associated with 3rd, 4th, and 6th cranial nerve palsies. Here, we report three children presenting with loss of vision. Two of them were cured with modified LMB-89 (lymphoma malignant B) chemotherapy regimen and radiotherapy. In one patient, loss of vision returned to normal in the left eye but persisted in the right eye. The second patient suffered from permanent visual loss, although the primary disease responded well to treatment. Unfortunately, the third patient died at an early phase of treatment. Acute blindness as a presenting symptom is rare in lymphoma. Early diagnosis and treatment is critical to increase the survival rate and to improve the quality of the vision.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>12544777</pmid><doi>10.1097/00043426-200301000-00014</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acute Disease Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blindness - diagnosis Blindness - etiology Blindness - therapy Child Child, Preschool Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - complications Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - therapy Male Medical sciences Radiotherapy, Adjuvant |
| title | Acute blindness as a presenting sign in childhood Non-Hodgkin lymphoma |
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