Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a)

Receptor tyrosine kinases activate mitogen-activated protein (MAP) kinases through Ras, Raf-1, and MEK. Receptor tyrosine kinases can be transactivated by G protein-coupled receptors coupling to G(i) and G(q). The human G protein-coupled serotonin receptors 5-HT(4(b)) and 5-HT(7(a)) couple to G(s) a...

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Veröffentlicht in:	The Journal of biological chemistry 2003-01, Vol.278 (5), p.3098-3104
Hauptverfasser:	Norum, Jens Henrik, Hart, Kent, Levy, Finn Olav
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Chlorocebus aethiops COS Cells Enzyme Activation GTP-Binding Protein alpha Subunits, Gs - metabolism Humans MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins c-raf - metabolism ras Proteins - metabolism Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT4 Recombinant Proteins - metabolism Serotonin - pharmacology Transfection
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