Comparative Effects of Human Igα and Igβ in Inducing Autoreactive Antibodies Against B Cells in Mice

Human and mouse Ig alpha molecules share only 58% amino acid sequence identity in their extracellular regions. However, mice immunized with a recombinant Fc fusion protein containing the extracellular portion of human Ig alpha produced significant amounts of IgG capable of binding to Ig alpha on mou...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-02, Vol.170 (3), p.1158-1166, Article 1158
Hauptverfasser:	Sheu, Jim J C, Cheng, Tammy, Chen, Huan Y, Lim, Carmay, Chang, Tse-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Bispecific - metabolism Antigen-Antibody Reactions Antigens, CD - administration & dosage Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Autoantibodies - biosynthesis Autoantibodies - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism Binding Sites, Antibody CD79 Antigens Cell Death - immunology Cell Line Down-Regulation - immunology Humans Immune Sera - metabolism Immunization Immunoglobulin Fc Fragments - administration & dosage Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - immunology Injections, Intraperitoneal Lymphopenia - immunology Male Mice Mice, Inbred BALB C Molecular Sequence Data Ovalbumin - administration & dosage Ovalbumin - immunology Receptors, Antigen, B-Cell - administration & dosage Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Receptors, Antigen, B-Cell - metabolism Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - immunology
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