The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on β-cell sensitivity in type 2 and nondiabetic subjects

The intestinally derived hormone glucagon-like peptide 1 (GLP-1) (7-36 amide) has potent effects on glucose-mediated insulin secretion, insulin gene expression, and beta-cell growth and differentiation. It is, therefore, considered a potential therapeutic agent for the treatment of type 2 diabetes....

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2003-02, Vol.52 (2), p.380-386
Hauptverfasser:	KJEMS, Lise L, HOLST, Jens J, VØLUND, Aage, MADSBAD, Sten
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism C-Peptide - blood Care and treatment Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucagon Glucagon - administration & dosage Glucagon - pharmacology Glucagon - physiology Glucagon-Like Peptide 1 Glucose Clamp Technique Humans Infusions, Intravenous Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Kinetics Male Medical sciences Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Peptide Fragments - physiology Physiological aspects Protein Precursors - administration & dosage Protein Precursors - pharmacology Protein Precursors - physiology Reference Values Type 2 diabetes
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