Biological activity of immunostimulatory CpG DNA motifs in domestic animals

Bacterial DNA contains a much higher frequency of CpG dinucleotides than are present in mammalian DNA. Furthermore, bacterial CpG dinucleotides are often not methylated. It is thought that these two features in combination with specific flanking bases constitute a CpG motif that is recognized as a “...

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Veröffentlicht in:	Veterinary Immunology and Immunopathology 2003-01, Vol.91 (2), p.89-103
Hauptverfasser:	Mutwiri, G, Pontarollo, R, Babiuk, S, Griebel, P, van Drunen Littel-van den Hurk, S, Mena, A, Tsang, C, Alcon, V, Nichani, A, Ioannou, X, Gomis, S, Townsend, H, Hecker, R, Potter, A, Babiuk, L.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Animals Animals, Domestic - immunology CpG DNA CpG Islands - immunology DNA, Bacterial - immunology Immunity, Innate - immunology Immunostimulation Oligodeoxynucleotides Species Specificity Vaccines, DNA - immunology
Online-Zugang:	Volltext
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