Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy
Proton spectroscopy can noninvasively provide useful information on brain tumor type and grade. Short‐ (30 ms) and long‐ (136 ms) echo time (TE) 1H spectra were acquired from normal white matter (NWM), meningiomas, grade II astrocytomas, anaplastic astrocytomas, glioblastomas, and metastases. Very l...
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| Veröffentlicht in: | Magnetic resonance in medicine 2003-02, Vol.49 (2), p.223-232 |
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| creator | Howe, F.A. Barton, S.J. Cudlip, S.A. Stubbs, M. Saunders, D.E. Murphy, M. Wilkins, P. Opstad, K.S. Doyle, V.L. McLean, M.A. Bell, B.A. Griffiths, J.R. |
| description | Proton spectroscopy can noninvasively provide useful information on brain tumor type and grade. Short‐ (30 ms) and long‐ (136 ms) echo time (TE) 1H spectra were acquired from normal white matter (NWM), meningiomas, grade II astrocytomas, anaplastic astrocytomas, glioblastomas, and metastases. Very low myo‐Inositol ([mI]) and creatine ([Cr]) were characteristic of meningiomas, and high [mI] characteristic of grade II astrocytomas. Tumor choline ([Cho]) was greater than NWM and increased with grade for grade II and anaplastic astrocytomas, but was highly variable for glioblastomas. Higher [Cho] and [Cr] correlated with low lipid and lactate (P < 0.05), indicating a dilution of metabolite concentrations due to necrosis in high‐grade tumors. Metabolite peak area ratios showed no correlation with lipids and mI/Cho (at TE = 30 ms), and Cr/Cho (at TE = 136 ms) best correlated with tumor grade. The quantified lipid, macromolecule, and lactate levels increased with grade of tumor, consistent with progression from hypoxia to necrosis. Quantification of lipids and macromolecules at short TE provided a good marker for tumor grade, and a scatter plot of the sum of alanine, lactate, and δ1.3 lipid signals vs. mI/Cho provided a simple way to separate most tumors by type and grade. Magn Reson Med 49:223–232, 2003. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.10367 |
| format | Article |
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Short‐ (30 ms) and long‐ (136 ms) echo time (TE) 1H spectra were acquired from normal white matter (NWM), meningiomas, grade II astrocytomas, anaplastic astrocytomas, glioblastomas, and metastases. Very low myo‐Inositol ([mI]) and creatine ([Cr]) were characteristic of meningiomas, and high [mI] characteristic of grade II astrocytomas. Tumor choline ([Cho]) was greater than NWM and increased with grade for grade II and anaplastic astrocytomas, but was highly variable for glioblastomas. Higher [Cho] and [Cr] correlated with low lipid and lactate (P < 0.05), indicating a dilution of metabolite concentrations due to necrosis in high‐grade tumors. Metabolite peak area ratios showed no correlation with lipids and mI/Cho (at TE = 30 ms), and Cr/Cho (at TE = 136 ms) best correlated with tumor grade. The quantified lipid, macromolecule, and lactate levels increased with grade of tumor, consistent with progression from hypoxia to necrosis. Quantification of lipids and macromolecules at short TE provided a good marker for tumor grade, and a scatter plot of the sum of alanine, lactate, and δ1.3 lipid signals vs. mI/Cho provided a simple way to separate most tumors by type and grade. Magn Reson Med 49:223–232, 2003. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.10367</identifier><identifier>PMID: 12541241</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>1H spectroscopy ; Alanine - analysis ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - analysis ; Astrocytoma - chemistry ; Biological and medical sciences ; Brain Neoplasms - chemistry ; Brain Neoplasms - secondary ; Choline - analysis ; Creatine - analysis ; Glioblastoma - chemistry ; grading ; Humans ; Inositol - analysis ; Investigative techniques, diagnostic techniques (general aspects) ; Lactic Acid - analysis ; Lipids - analysis ; Magnetic Resonance Spectroscopy ; Medical sciences ; Meningeal Neoplasms - chemistry ; Meningioma - chemistry ; metabolites ; Nervous system ; Neurology ; quantitation ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; tumor ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Magnetic resonance in medicine, 2003-02, Vol.49 (2), p.223-232</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.10367$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.10367$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27933,27934,45583,45584,46418,46842</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14496714$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12541241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howe, F.A.</creatorcontrib><creatorcontrib>Barton, S.J.</creatorcontrib><creatorcontrib>Cudlip, S.A.</creatorcontrib><creatorcontrib>Stubbs, M.</creatorcontrib><creatorcontrib>Saunders, D.E.</creatorcontrib><creatorcontrib>Murphy, M.</creatorcontrib><creatorcontrib>Wilkins, P.</creatorcontrib><creatorcontrib>Opstad, K.S.</creatorcontrib><creatorcontrib>Doyle, V.L.</creatorcontrib><creatorcontrib>McLean, M.A.</creatorcontrib><creatorcontrib>Bell, B.A.</creatorcontrib><creatorcontrib>Griffiths, J.R.</creatorcontrib><title>Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>Proton spectroscopy can noninvasively provide useful information on brain tumor type and grade. Short‐ (30 ms) and long‐ (136 ms) echo time (TE) 1H spectra were acquired from normal white matter (NWM), meningiomas, grade II astrocytomas, anaplastic astrocytomas, glioblastomas, and metastases. Very low myo‐Inositol ([mI]) and creatine ([Cr]) were characteristic of meningiomas, and high [mI] characteristic of grade II astrocytomas. Tumor choline ([Cho]) was greater than NWM and increased with grade for grade II and anaplastic astrocytomas, but was highly variable for glioblastomas. Higher [Cho] and [Cr] correlated with low lipid and lactate (P < 0.05), indicating a dilution of metabolite concentrations due to necrosis in high‐grade tumors. Metabolite peak area ratios showed no correlation with lipids and mI/Cho (at TE = 30 ms), and Cr/Cho (at TE = 136 ms) best correlated with tumor grade. The quantified lipid, macromolecule, and lactate levels increased with grade of tumor, consistent with progression from hypoxia to necrosis. Quantification of lipids and macromolecules at short TE provided a good marker for tumor grade, and a scatter plot of the sum of alanine, lactate, and δ1.3 lipid signals vs. mI/Cho provided a simple way to separate most tumors by type and grade. Magn Reson Med 49:223–232, 2003. © 2003 Wiley‐Liss, Inc.</description><subject>1H spectroscopy</subject><subject>Alanine - analysis</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - analysis</subject><subject>Astrocytoma - chemistry</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - chemistry</subject><subject>Brain Neoplasms - secondary</subject><subject>Choline - analysis</subject><subject>Creatine - analysis</subject><subject>Glioblastoma - chemistry</subject><subject>grading</subject><subject>Humans</subject><subject>Inositol - analysis</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lactic Acid - analysis</subject><subject>Lipids - analysis</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Meningeal Neoplasms - chemistry</subject><subject>Meningioma - chemistry</subject><subject>metabolites</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>quantitation</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>tumor</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EotuFA38A-UJvof6KHR9RoS1VF6QVHxIXa-I4xZDEW9tZuv8et7vQk0d6n3c8My9Cryh5Swlhp2McS8GleoIWtGasYrUWT9GCKEEqTrU4Qscp_SKEaK3Ec3REWS0oE3SB-pXL0IbBW7yJofeDSzj0-Oc8woTbCH7CeR5DTHhOfrrBtzNM2WfIfutwEbd-GzC9xCPcTC6XLtGlMMFkHU4bZ3MMyYbN7gV61sOQ3MvDu0Rfzz98Obusrj9ffDx7d115JrmqGimtVJQxKTtQjWw7TRzUvAVoema7VrStsr3rFOmp1ExrzijpaieB2UYyvkQn-75lmdvZpWxGn6wbBphcmJNRrByAl7-W6PUBnNvRdWYT_QhxZ_5dpgBvDgAkC0Mfy04-PXJC6DKpKNzpnvtTbrd71Im5j8aUaMxDNGa1Xj0UxVHtHT5ld_ffAfG3KaqqzfdPF2b9Y_1tdcUb857_BfoPkO0</recordid><startdate>200302</startdate><enddate>200302</enddate><creator>Howe, F.A.</creator><creator>Barton, S.J.</creator><creator>Cudlip, S.A.</creator><creator>Stubbs, M.</creator><creator>Saunders, D.E.</creator><creator>Murphy, M.</creator><creator>Wilkins, P.</creator><creator>Opstad, K.S.</creator><creator>Doyle, V.L.</creator><creator>McLean, M.A.</creator><creator>Bell, B.A.</creator><creator>Griffiths, J.R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200302</creationdate><title>Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy</title><author>Howe, F.A. ; Barton, S.J. ; Cudlip, S.A. ; Stubbs, M. ; Saunders, D.E. ; Murphy, M. ; Wilkins, P. ; Opstad, K.S. ; Doyle, V.L. ; McLean, M.A. ; Bell, B.A. ; Griffiths, J.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2637-866c6712266da786bd90ea53baa8f2cdb4bb7cfed70f1692993210d5e6a2c8623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>1H spectroscopy</topic><topic>Alanine - analysis</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - analysis</topic><topic>Astrocytoma - chemistry</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - chemistry</topic><topic>Brain Neoplasms - secondary</topic><topic>Choline - analysis</topic><topic>Creatine - analysis</topic><topic>Glioblastoma - chemistry</topic><topic>grading</topic><topic>Humans</topic><topic>Inositol - analysis</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lactic Acid - analysis</topic><topic>Lipids - analysis</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Meningeal Neoplasms - chemistry</topic><topic>Meningioma - chemistry</topic><topic>metabolites</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>quantitation</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>tumor</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howe, F.A.</creatorcontrib><creatorcontrib>Barton, S.J.</creatorcontrib><creatorcontrib>Cudlip, S.A.</creatorcontrib><creatorcontrib>Stubbs, M.</creatorcontrib><creatorcontrib>Saunders, D.E.</creatorcontrib><creatorcontrib>Murphy, M.</creatorcontrib><creatorcontrib>Wilkins, P.</creatorcontrib><creatorcontrib>Opstad, K.S.</creatorcontrib><creatorcontrib>Doyle, V.L.</creatorcontrib><creatorcontrib>McLean, M.A.</creatorcontrib><creatorcontrib>Bell, B.A.</creatorcontrib><creatorcontrib>Griffiths, J.R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Howe, F.A.</au><au>Barton, S.J.</au><au>Cudlip, S.A.</au><au>Stubbs, M.</au><au>Saunders, D.E.</au><au>Murphy, M.</au><au>Wilkins, P.</au><au>Opstad, K.S.</au><au>Doyle, V.L.</au><au>McLean, M.A.</au><au>Bell, B.A.</au><au>Griffiths, J.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2003-02</date><risdate>2003</risdate><volume>49</volume><issue>2</issue><spage>223</spage><epage>232</epage><pages>223-232</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Proton spectroscopy can noninvasively provide useful information on brain tumor type and grade. Short‐ (30 ms) and long‐ (136 ms) echo time (TE) 1H spectra were acquired from normal white matter (NWM), meningiomas, grade II astrocytomas, anaplastic astrocytomas, glioblastomas, and metastases. Very low myo‐Inositol ([mI]) and creatine ([Cr]) were characteristic of meningiomas, and high [mI] characteristic of grade II astrocytomas. Tumor choline ([Cho]) was greater than NWM and increased with grade for grade II and anaplastic astrocytomas, but was highly variable for glioblastomas. Higher [Cho] and [Cr] correlated with low lipid and lactate (P < 0.05), indicating a dilution of metabolite concentrations due to necrosis in high‐grade tumors. Metabolite peak area ratios showed no correlation with lipids and mI/Cho (at TE = 30 ms), and Cr/Cho (at TE = 136 ms) best correlated with tumor grade. The quantified lipid, macromolecule, and lactate levels increased with grade of tumor, consistent with progression from hypoxia to necrosis. Quantification of lipids and macromolecules at short TE provided a good marker for tumor grade, and a scatter plot of the sum of alanine, lactate, and δ1.3 lipid signals vs. mI/Cho provided a simple way to separate most tumors by type and grade. Magn Reson Med 49:223–232, 2003. © 2003 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12541241</pmid><doi>10.1002/mrm.10367</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1H spectroscopy Alanine - analysis Aspartic Acid - analogs & derivatives Aspartic Acid - analysis Astrocytoma - chemistry Biological and medical sciences Brain Neoplasms - chemistry Brain Neoplasms - secondary Choline - analysis Creatine - analysis Glioblastoma - chemistry grading Humans Inositol - analysis Investigative techniques, diagnostic techniques (general aspects) Lactic Acid - analysis Lipids - analysis Magnetic Resonance Spectroscopy Medical sciences Meningeal Neoplasms - chemistry Meningioma - chemistry metabolites Nervous system Neurology quantitation Radiodiagnosis. Nmr imagery. Nmr spectrometry tumor Tumors of the nervous system. Phacomatoses |
| title | Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy |
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