Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury
Ketamine is used as an anaesthetic agent for short surgical procedures, and as a sedative and analgesic in intensive care patients. Intensive care patients with brain or spinal cord injury may have physiological changes that could alter the pharmacokinetics of ketamine. The pharmacokinetics of ketam...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 2003-02, Vol.90 (2), p.155-160 |
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| creator | Hijazi, Y. Bodonian, C. Bolon, M. Salord, F. Boulieu, R. |
| description | Ketamine is used as an anaesthetic agent for short surgical procedures, and as a sedative and analgesic in intensive care patients. Intensive care patients with brain or spinal cord injury may have physiological changes that could alter the pharmacokinetics of ketamine. The pharmacokinetics of ketamine have been studied in healthy volunteers and in patients undergoing different types of surgery, but no data are available in intensive care patients.
We determined the pharmacokinetics of ketamine and its active metabolites, norketamine and dehydronorketamine, in 12 intensive care patients with brain or spinal cord injury. The effect of ketamine on haemodynamic variables was also investigated.
The total clearance of ketamine, mean (sd), was 36.0 (13.3) ml min−1 kg−1, the volume of distribution (Vβ) was 16.0 (8.6) litre kg−1, and the elimination half-life was 4.9 (1.6) h. Ketamine did not alter any haemodynamic variables in the patients studied.
Pharmacokinetic variables of ketamine in intensive care patients are greater than in healthy volunteers and in surgical patients. The increase in the volume of distribution is greater than the increase in clearance, resulting in a longer estimated half-life of ketamine in this patient group. |
| doi_str_mv | 10.1093/bja/aeg028 |
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We determined the pharmacokinetics of ketamine and its active metabolites, norketamine and dehydronorketamine, in 12 intensive care patients with brain or spinal cord injury. The effect of ketamine on haemodynamic variables was also investigated.
The total clearance of ketamine, mean (sd), was 36.0 (13.3) ml min−1 kg−1, the volume of distribution (Vβ) was 16.0 (8.6) litre kg−1, and the elimination half-life was 4.9 (1.6) h. Ketamine did not alter any haemodynamic variables in the patients studied.
Pharmacokinetic variables of ketamine in intensive care patients are greater than in healthy volunteers and in surgical patients. The increase in the volume of distribution is greater than the increase in clearance, resulting in a longer estimated half-life of ketamine in this patient group.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/aeg028</identifier><identifier>PMID: 12538370</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Analysis of Variance ; Anesthetics, Dissociative - blood ; Anesthetics, Dissociative - pharmacokinetics ; Anesthetics, Dissociative - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; brain ; Brain Injuries - metabolism ; Brain Injuries - therapy ; brain, injury ; Critical Care - methods ; Female ; Half-Life ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Humans ; Hypnotics. Sedatives ; injury ; intensive care ; ketamine ; Ketamine - analogs & derivatives ; Ketamine - blood ; Ketamine - pharmacokinetics ; Ketamine - pharmacology ; Male ; Medical sciences ; Metabolic Clearance Rate ; Middle Aged ; Neuropharmacology ; pharmacokinetics ; pharmacokinetics, ketamine ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Spinal Cord Injuries - metabolism ; Spinal Cord Injuries - therapy</subject><ispartof>British journal of anaesthesia : BJA, 2003-02, Vol.90 (2), p.155-160</ispartof><rights>2003 British Journal of Anaesthesia</rights><rights>2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright British Medical Association Feb 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4048-1f21bf4b63eb28f2e9faae2358d58ec696d7a15e9aed3d30916a653ab208b4a3</citedby><cites>FETCH-LOGICAL-c4048-1f21bf4b63eb28f2e9faae2358d58ec696d7a15e9aed3d30916a653ab208b4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14520358$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12538370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hijazi, Y.</creatorcontrib><creatorcontrib>Bodonian, C.</creatorcontrib><creatorcontrib>Bolon, M.</creatorcontrib><creatorcontrib>Salord, F.</creatorcontrib><creatorcontrib>Boulieu, R.</creatorcontrib><title>Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury</title><title>British journal of anaesthesia : BJA</title><addtitle>Br. J. Anaesth</addtitle><addtitle>Br. J. Anaesth</addtitle><description>Ketamine is used as an anaesthetic agent for short surgical procedures, and as a sedative and analgesic in intensive care patients. Intensive care patients with brain or spinal cord injury may have physiological changes that could alter the pharmacokinetics of ketamine. The pharmacokinetics of ketamine have been studied in healthy volunteers and in patients undergoing different types of surgery, but no data are available in intensive care patients.
We determined the pharmacokinetics of ketamine and its active metabolites, norketamine and dehydronorketamine, in 12 intensive care patients with brain or spinal cord injury. The effect of ketamine on haemodynamic variables was also investigated.
The total clearance of ketamine, mean (sd), was 36.0 (13.3) ml min−1 kg−1, the volume of distribution (Vβ) was 16.0 (8.6) litre kg−1, and the elimination half-life was 4.9 (1.6) h. Ketamine did not alter any haemodynamic variables in the patients studied.
Pharmacokinetic variables of ketamine in intensive care patients are greater than in healthy volunteers and in surgical patients. The increase in the volume of distribution is greater than the increase in clearance, resulting in a longer estimated half-life of ketamine in this patient group.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Anesthetics, Dissociative - blood</subject><subject>Anesthetics, Dissociative - pharmacokinetics</subject><subject>Anesthetics, Dissociative - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>brain</subject><subject>Brain Injuries - metabolism</subject><subject>Brain Injuries - therapy</subject><subject>brain, injury</subject><subject>Critical Care - methods</subject><subject>Female</subject><subject>Half-Life</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Hypnotics. Sedatives</subject><subject>injury</subject><subject>intensive care</subject><subject>ketamine</subject><subject>Ketamine - analogs & derivatives</subject><subject>Ketamine - blood</subject><subject>Ketamine - pharmacokinetics</subject><subject>Ketamine - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>pharmacokinetics</subject><subject>pharmacokinetics, ketamine</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Spinal Cord Injuries - metabolism</subject><subject>Spinal Cord Injuries - therapy</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90V2L1DAUBuAiijuu3vgDpAjuhVA3X23aS1lXVx3QiwHFm3CanDqZaZOatKvz783SwQERIZAQnuTkvMmyp5S8oqThl-0OLgG_E1bfy1ZUSFpUUtL72YoQIgvSUHaWPYpxRwiVrCkfZmeUlbzmkqyy3ecthAG031uHk9UxB2fyLeDgzcHBcLfju3yPU1o7zK1LY0IX7S3mGgLmI0wW3RTzn3ba5m2ARHzI42gd9Ln2waQTuzkcHmcPOugjPjnO59nm7fXm6qZYf3r3_ur1utCCiLqgHaNtJ9qKY8vqjmHTASDjZW3KGnXVVEYCLbEBNNzw1F4FVcmhZaRuBfDz7GK5dgz-x4xxUoONGvseHPo5qhSBFLRmCT7_C-78HNKjo6KNrBshRJnQywXp4GMM2Kkx2AHCQVGi7tJXKX21pJ_ws-ONczugOdFj3Am8OAKIGvougNM2npwoGUmNnpyfx_8XLBZn44S__kgIe1VJLkt18_Wb-vBxzb_Q6o3aJC8Wjyn_W4tBRZ0-T6OxAfWkjLf_KvMbiQu8xA</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Hijazi, Y.</creator><creator>Bodonian, C.</creator><creator>Bolon, M.</creator><creator>Salord, F.</creator><creator>Boulieu, R.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury</title><author>Hijazi, Y. ; Bodonian, C. ; Bolon, M. ; Salord, F. ; Boulieu, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4048-1f21bf4b63eb28f2e9faae2358d58ec696d7a15e9aed3d30916a653ab208b4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Anesthetics, Dissociative - blood</topic><topic>Anesthetics, Dissociative - pharmacokinetics</topic><topic>Anesthetics, Dissociative - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>brain</topic><topic>Brain Injuries - metabolism</topic><topic>Brain Injuries - therapy</topic><topic>brain, injury</topic><topic>Critical Care - methods</topic><topic>Female</topic><topic>Half-Life</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Hypnotics. Sedatives</topic><topic>injury</topic><topic>intensive care</topic><topic>ketamine</topic><topic>Ketamine - analogs & derivatives</topic><topic>Ketamine - blood</topic><topic>Ketamine - pharmacokinetics</topic><topic>Ketamine - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>pharmacokinetics</topic><topic>pharmacokinetics, ketamine</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Spinal Cord Injuries - metabolism</topic><topic>Spinal Cord Injuries - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hijazi, Y.</creatorcontrib><creatorcontrib>Bodonian, C.</creatorcontrib><creatorcontrib>Bolon, M.</creatorcontrib><creatorcontrib>Salord, F.</creatorcontrib><creatorcontrib>Boulieu, R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hijazi, Y.</au><au>Bodonian, C.</au><au>Bolon, M.</au><au>Salord, F.</au><au>Boulieu, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br. J. Anaesth</stitle><addtitle>Br. J. Anaesth</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>90</volume><issue>2</issue><spage>155</spage><epage>160</epage><pages>155-160</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Ketamine is used as an anaesthetic agent for short surgical procedures, and as a sedative and analgesic in intensive care patients. Intensive care patients with brain or spinal cord injury may have physiological changes that could alter the pharmacokinetics of ketamine. The pharmacokinetics of ketamine have been studied in healthy volunteers and in patients undergoing different types of surgery, but no data are available in intensive care patients.
We determined the pharmacokinetics of ketamine and its active metabolites, norketamine and dehydronorketamine, in 12 intensive care patients with brain or spinal cord injury. The effect of ketamine on haemodynamic variables was also investigated.
The total clearance of ketamine, mean (sd), was 36.0 (13.3) ml min−1 kg−1, the volume of distribution (Vβ) was 16.0 (8.6) litre kg−1, and the elimination half-life was 4.9 (1.6) h. Ketamine did not alter any haemodynamic variables in the patients studied.
Pharmacokinetic variables of ketamine in intensive care patients are greater than in healthy volunteers and in surgical patients. The increase in the volume of distribution is greater than the increase in clearance, resulting in a longer estimated half-life of ketamine in this patient group.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12538370</pmid><doi>10.1093/bja/aeg028</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of anaesthesia : BJA, 2003-02, Vol.90 (2), p.155-160 |
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| subjects | Adult Analysis of Variance Anesthetics, Dissociative - blood Anesthetics, Dissociative - pharmacokinetics Anesthetics, Dissociative - pharmacology Biological and medical sciences Blood Pressure - drug effects brain Brain Injuries - metabolism Brain Injuries - therapy brain, injury Critical Care - methods Female Half-Life Heart Rate - drug effects Hemodynamics - drug effects Humans Hypnotics. Sedatives injury intensive care ketamine Ketamine - analogs & derivatives Ketamine - blood Ketamine - pharmacokinetics Ketamine - pharmacology Male Medical sciences Metabolic Clearance Rate Middle Aged Neuropharmacology pharmacokinetics pharmacokinetics, ketamine Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Spinal Cord Injuries - metabolism Spinal Cord Injuries - therapy |
| title | Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury |
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