Antigenic heterogeneity of strains of Saccharomyces cerevisiae and Candida albicans recognised by serum antibodies from patients with Crohn's disease
The antigenic heterogeneity of twelve strains of Saccharomyces cerevisiae and serovar A and B strains of Candida albicans was investigated by cross‐absorption of serum antibodies from a patient with Crohn's disease. On the basis of common antibody absorption patterns, eleven of the yeast strain...
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| Veröffentlicht in: | FEMS microbiology immunology 1992-04, Vol.89 (4), p.219-224 |
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| creator | McKenzie, H. Parratt, D. Main, J. Pennington, C.R. |
| description | The antigenic heterogeneity of twelve strains of Saccharomyces cerevisiae and serovar A and B strains of Candida albicans was investigated by cross‐absorption of serum antibodies from a patient with Crohn's disease. On the basis of common antibody absorption patterns, eleven of the yeast strains were divided into Group 1 (five S. cerevisiae), Group 2 (two C. albicans, one S. cerevisiae) and Group 3 (three S. cerevisiae). The remaining three S. cerevisiae strains (Group 4) showed unique absorption patterns. The antigenic relationship between S. cerevisiae and C. albicans was further studied by cross‐absorption of sera from eight patients with Crohn's disease. This confirmed a limited degree of cross‐reaction between most strains of S. cerevisiae and C. albicans, but C. albicans serovar B significantly absorbed antibodies to more S. cerevisiae strains than did C. albicans serovar A. The results demonstrate considerable antigenic heterogeneity of S. cerevisiae and suggest that the elevated serum antibody levels to S. cerevisiae found in Crohn's disease are directed against multiple antigens. |
| doi_str_mv | 10.1111/j.1574-6968.1992.tb04997.x |
| format | Article |
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On the basis of common antibody absorption patterns, eleven of the yeast strains were divided into Group 1 (five S. cerevisiae), Group 2 (two C. albicans, one S. cerevisiae) and Group 3 (three S. cerevisiae). The remaining three S. cerevisiae strains (Group 4) showed unique absorption patterns. The antigenic relationship between S. cerevisiae and C. albicans was further studied by cross‐absorption of sera from eight patients with Crohn's disease. This confirmed a limited degree of cross‐reaction between most strains of S. cerevisiae and C. albicans, but C. albicans serovar B significantly absorbed antibodies to more S. cerevisiae strains than did C. albicans serovar A. The results demonstrate considerable antigenic heterogeneity of S. cerevisiae and suggest that the elevated serum antibody levels to S. cerevisiae found in Crohn's disease are directed against multiple antigens.</description><identifier>ISSN: 0378-1097</identifier><identifier>ISSN: 0920-8534</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1111/j.1574-6968.1992.tb04997.x</identifier><identifier>PMID: 1599707</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Antibodies, Fungal - blood ; Antigens, Fungal ; Candida albicans ; Candida albicans - classification ; Candida albicans - immunology ; Crohn Disease - immunology ; Crohn's disease ; Cross Reactions ; Humans ; Immunoglobulin G - blood ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - classification ; Saccharomyces cerevisiae - immunology ; Species Specificity</subject><ispartof>FEMS microbiology immunology, 1992-04, Vol.89 (4), p.219-224</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3019-9143aa3a311acf7d33df588ddb2caa20141e5bc19ace765c5c5f4c2fc18726733</citedby><cites>FETCH-LOGICAL-c3019-9143aa3a311acf7d33df588ddb2caa20141e5bc19ace765c5c5f4c2fc18726733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-6968.1992.tb04997.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-6968.1992.tb04997.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1599707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McKenzie, H.</creatorcontrib><creatorcontrib>Parratt, D.</creatorcontrib><creatorcontrib>Main, J.</creatorcontrib><creatorcontrib>Pennington, C.R.</creatorcontrib><title>Antigenic heterogeneity of strains of Saccharomyces cerevisiae and Candida albicans recognised by serum antibodies from patients with Crohn's disease</title><title>FEMS microbiology immunology</title><addtitle>FEMS Microbiol Immunol</addtitle><description>The antigenic heterogeneity of twelve strains of Saccharomyces cerevisiae and serovar A and B strains of Candida albicans was investigated by cross‐absorption of serum antibodies from a patient with Crohn's disease. On the basis of common antibody absorption patterns, eleven of the yeast strains were divided into Group 1 (five S. cerevisiae), Group 2 (two C. albicans, one S. cerevisiae) and Group 3 (three S. cerevisiae). The remaining three S. cerevisiae strains (Group 4) showed unique absorption patterns. The antigenic relationship between S. cerevisiae and C. albicans was further studied by cross‐absorption of sera from eight patients with Crohn's disease. This confirmed a limited degree of cross‐reaction between most strains of S. cerevisiae and C. albicans, but C. albicans serovar B significantly absorbed antibodies to more S. cerevisiae strains than did C. albicans serovar A. The results demonstrate considerable antigenic heterogeneity of S. cerevisiae and suggest that the elevated serum antibody levels to S. cerevisiae found in Crohn's disease are directed against multiple antigens.</description><subject>Antibodies, Fungal - blood</subject><subject>Antigens, Fungal</subject><subject>Candida albicans</subject><subject>Candida albicans - classification</subject><subject>Candida albicans - immunology</subject><subject>Crohn Disease - immunology</subject><subject>Crohn's disease</subject><subject>Cross Reactions</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - classification</subject><subject>Saccharomyces cerevisiae - immunology</subject><subject>Species Specificity</subject><issn>0378-1097</issn><issn>0920-8534</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUV-L1DAQD6Kc6-lHEIIP-tSaNG3T-CAci6fCig_qc5gm09ssbbMmWe_6Qfy-puyiz05gZuD3JzA_Ql5xVvJcbw8lb2RdtKrtSq5UVaae1UrJ8uER2fyFHpMNE7IrOFPyKXkW44ExVlesvSJXvMl0Jjfk982c3B3OztA9Jgw-7-jSQv1AYwrg5riu38CYPQQ_LQYjNRjwl4sOkMJs6TY3Z4HC2DsDWRDQ-LvZRbS0X2jEcJoyMbneW5flQ_ahR0gO5xTpvUt7ug1-P7-J1GYRRHxOngwwRnxxmdfkx-2H79tPxe7rx8_bm11hBOOqULwWAAIE52AGaYWwQ9N11vaVAagYrzk2veEKDMq2MfkNtakGwztZtVKIa_L67HsM_ucJY9KTiwbHEWb0p6hlpaRoRJ2J785EE3yMAQd9DG6CsGjO9JqJPuj18Ho9vF4z0ZdM9EMWv7z8cuontP-k5xAy_v6M37sRl_9w1rdfdhVX4g8X96CB</recordid><startdate>199204</startdate><enddate>199204</enddate><creator>McKenzie, H.</creator><creator>Parratt, D.</creator><creator>Main, J.</creator><creator>Pennington, C.R.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199204</creationdate><title>Antigenic heterogeneity of strains of Saccharomyces cerevisiae and Candida albicans recognised by serum antibodies from patients with Crohn's disease</title><author>McKenzie, H. ; Parratt, D. ; Main, J. ; Pennington, C.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3019-9143aa3a311acf7d33df588ddb2caa20141e5bc19ace765c5c5f4c2fc18726733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antibodies, Fungal - blood</topic><topic>Antigens, Fungal</topic><topic>Candida albicans</topic><topic>Candida albicans - classification</topic><topic>Candida albicans - immunology</topic><topic>Crohn Disease - immunology</topic><topic>Crohn's disease</topic><topic>Cross Reactions</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - classification</topic><topic>Saccharomyces cerevisiae - immunology</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKenzie, H.</creatorcontrib><creatorcontrib>Parratt, D.</creatorcontrib><creatorcontrib>Main, J.</creatorcontrib><creatorcontrib>Pennington, C.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS microbiology immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKenzie, H.</au><au>Parratt, D.</au><au>Main, J.</au><au>Pennington, C.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antigenic heterogeneity of strains of Saccharomyces cerevisiae and Candida albicans recognised by serum antibodies from patients with Crohn's disease</atitle><jtitle>FEMS microbiology immunology</jtitle><addtitle>FEMS Microbiol Immunol</addtitle><date>1992-04</date><risdate>1992</risdate><volume>89</volume><issue>4</issue><spage>219</spage><epage>224</epage><pages>219-224</pages><issn>0378-1097</issn><issn>0920-8534</issn><eissn>1574-6968</eissn><abstract>The antigenic heterogeneity of twelve strains of Saccharomyces cerevisiae and serovar A and B strains of Candida albicans was investigated by cross‐absorption of serum antibodies from a patient with Crohn's disease. On the basis of common antibody absorption patterns, eleven of the yeast strains were divided into Group 1 (five S. cerevisiae), Group 2 (two C. albicans, one S. cerevisiae) and Group 3 (three S. cerevisiae). The remaining three S. cerevisiae strains (Group 4) showed unique absorption patterns. The antigenic relationship between S. cerevisiae and C. albicans was further studied by cross‐absorption of sera from eight patients with Crohn's disease. This confirmed a limited degree of cross‐reaction between most strains of S. cerevisiae and C. albicans, but C. albicans serovar B significantly absorbed antibodies to more S. cerevisiae strains than did C. albicans serovar A. The results demonstrate considerable antigenic heterogeneity of S. cerevisiae and suggest that the elevated serum antibody levels to S. cerevisiae found in Crohn's disease are directed against multiple antigens.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1599707</pmid><doi>10.1111/j.1574-6968.1992.tb04997.x</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0378-1097 |
| ispartof | FEMS microbiology immunology, 1992-04, Vol.89 (4), p.219-224 |
| issn | 0378-1097 0920-8534 1574-6968 |
| language | eng |
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| source | MEDLINE; Oxford University Press Archive; Access via Wiley Online Library; Oxford Journals Open Access Collection; Alma/SFX Local Collection |
| subjects | Antibodies, Fungal - blood Antigens, Fungal Candida albicans Candida albicans - classification Candida albicans - immunology Crohn Disease - immunology Crohn's disease Cross Reactions Humans Immunoglobulin G - blood Saccharomyces cerevisiae Saccharomyces cerevisiae - classification Saccharomyces cerevisiae - immunology Species Specificity |
| title | Antigenic heterogeneity of strains of Saccharomyces cerevisiae and Candida albicans recognised by serum antibodies from patients with Crohn's disease |
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