Basic Fibroblast Growth Factor Activates Endothelial Nitric-Oxide Synthase in CHO-K1 Cells via the Activation of Ceramide Synthesis

In this study, we analyzed the intracellular mechanisms leading to basic fibroblast growth factor (bFGF)-dependent production of NO in Chinese hamster ovary (CHO)-K1 cells and a possible physiological role for such an effect. bFGF induces NO production through the activation of the endothelial form...

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Veröffentlicht in:	Molecular pharmacology 2003-02, Vol.63 (2), p.297-310
Hauptverfasser:	Florio, Tullio, Arena, Sara, Pattarozzi, Alessandra, Thellung, Stefano, Corsaro, Alessandro, Villa, Valentina, Massa, Alessandro, Diana, Fabrizio, Spoto, Giuseppe, Forcella, Sabrina, Damonte, Gianluca, Filocamo, Mirella, Benatti, Umberto, Schettini, Gennaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport - drug effects Calcium - metabolism Cell Division - drug effects Ceramides - biosynthesis CHO Cells Cricetinae Cytosol - metabolism Enzyme Activation - drug effects Fibroblast Growth Factor 2 - pharmacology Lysophospholipids Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Sphingomyelin Phosphodiesterase - metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism
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