A Comparison of Magnesium Sulfate and Nimodipine for the Prevention of Eclampsia
In this randomized, unblinded, multicenter study, magnesium sulfate proved more effective than nimodipine, a cerebral vasodilator, in preventing seizures in women with severe preeclampsia. The risk of seizure was three times as high in the group given nimodipine as in the group given magnesium sulfa...
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| Veröffentlicht in: | The New England journal of medicine 2003-01, Vol.348 (4), p.304-311 |
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| creator | Belfort, Michael A Anthony, John Saade, George R Allen, John C |
| description | In this randomized, unblinded, multicenter study, magnesium sulfate proved more effective than nimodipine, a cerebral vasodilator, in preventing seizures in women with severe preeclampsia. The risk of seizure was three times as high in the group given nimodipine as in the group given magnesium sulfate.
The risk of seizure was higher in the nimodipine group.
Cerebral infarction and hemorrhage still account for the majority of deaths from eclampsia and preeclampsia.
1
,
2
Preeclampsia causes regional vasoconstriction, and many believe that eclampsia results from cerebral vasospasm and resultant ischemia.
3
–
6
Magnesium sulfate is generally accepted as the treatment of choice for eclampsia.
7
–
9
The use of magnesium sulfate to prevent eclampsia has been common in the United States for decades
10
,
11
but has not been internationally adopted. The placebo-controlled Magnesium Sulphate for Prevention of Eclampsia (MAGPIE) trial
12
recently confirmed the prophylactic action of magnesium sulfate and is likely to increase the use of this agent in women . . . |
| doi_str_mv | 10.1056/NEJMoa021180 |
| format | Article |
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The risk of seizure was higher in the nimodipine group.
Cerebral infarction and hemorrhage still account for the majority of deaths from eclampsia and preeclampsia.
1
,
2
Preeclampsia causes regional vasoconstriction, and many believe that eclampsia results from cerebral vasospasm and resultant ischemia.
3
–
6
Magnesium sulfate is generally accepted as the treatment of choice for eclampsia.
7
–
9
The use of magnesium sulfate to prevent eclampsia has been common in the United States for decades
10
,
11
but has not been internationally adopted. The placebo-controlled Magnesium Sulphate for Prevention of Eclampsia (MAGPIE) trial
12
recently confirmed the prophylactic action of magnesium sulfate and is likely to increase the use of this agent in women . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa021180</identifier><identifier>PMID: 12540643</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Anticonvulsants - therapeutic use ; Biological and medical sciences ; Calcium Channel Blockers - therapeutic use ; Drug dosages ; Drug therapy ; Eclampsia - prevention & control ; Female ; Genital system. Reproduction ; Humans ; Ischemia ; Logistic Models ; Magnesium Sulfate - therapeutic use ; Medical sciences ; Nifedipine - therapeutic use ; Pharmacology. Drug treatments ; Pre-Eclampsia - drug therapy ; Preeclampsia ; Pregnancy ; Risk ; Seizures - prevention & control ; Vasodilator Agents - therapeutic use ; Vasospasm, Intracranial - prevention & control</subject><ispartof>The New England journal of medicine, 2003-01, Vol.348 (4), p.304-311</ispartof><rights>Copyright © 2003 Massachusetts Medical Society. All rights reserved.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-7d999d3ae5b2cabf20fe7dcd9137241f43add1eea9314ef666a2f0e2289ad2783</citedby><cites>FETCH-LOGICAL-c564t-7d999d3ae5b2cabf20fe7dcd9137241f43add1eea9314ef666a2f0e2289ad2783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa021180$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/220126175?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,778,782,2748,2749,26090,27911,27912,52369,54051,64370,64372,64374,72224</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14482390$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12540643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belfort, Michael A</creatorcontrib><creatorcontrib>Anthony, John</creatorcontrib><creatorcontrib>Saade, George R</creatorcontrib><creatorcontrib>Allen, John C</creatorcontrib><creatorcontrib>Nimodipine Study Group</creatorcontrib><title>A Comparison of Magnesium Sulfate and Nimodipine for the Prevention of Eclampsia</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this randomized, unblinded, multicenter study, magnesium sulfate proved more effective than nimodipine, a cerebral vasodilator, in preventing seizures in women with severe preeclampsia. The risk of seizure was three times as high in the group given nimodipine as in the group given magnesium sulfate.
The risk of seizure was higher in the nimodipine group.
Cerebral infarction and hemorrhage still account for the majority of deaths from eclampsia and preeclampsia.
1
,
2
Preeclampsia causes regional vasoconstriction, and many believe that eclampsia results from cerebral vasospasm and resultant ischemia.
3
–
6
Magnesium sulfate is generally accepted as the treatment of choice for eclampsia.
7
–
9
The use of magnesium sulfate to prevent eclampsia has been common in the United States for decades
10
,
11
but has not been internationally adopted. The placebo-controlled Magnesium Sulphate for Prevention of Eclampsia (MAGPIE) trial
12
recently confirmed the prophylactic action of magnesium sulfate and is likely to increase the use of this agent in women . . .</description><subject>Anticonvulsants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Eclampsia - prevention & control</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Logistic Models</subject><subject>Magnesium Sulfate - therapeutic use</subject><subject>Medical sciences</subject><subject>Nifedipine - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Pre-Eclampsia - drug therapy</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Risk</subject><subject>Seizures - prevention & control</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Vasospasm, Intracranial - prevention & control</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0E1v1DAQBmALgehSeusZWQg4keKvxPGxWi1faksl2nM0G49br2I72AkS_76pdqUihC9zeeYd6yXklLMzzurm09Xm-2UCJjhv2TOy4rWUlVKseU5WjIm2UtrII_KqlB1bHlfmJTniol6EkityfU7XKYyQfUmRJkcv4S5i8XOgP-fBwYQUoqVXPiTrRx-RupTpdI_0OuNvjJPfr236AcJYPLwmLxwMBU8O85jcft7crL9WFz--fFufX1R93aip0tYYYyVgvRU9bJ1gDrXtreFSC8WdkmAtRwQjuULXNA0Ix1CI1oAVupXH5MM-d8zp14xl6oIvPQ4DRExz6bQwmmvFF_j2H7hLc47L3zohGBcN1_WCPu5Rn1MpGV03Zh8g_-k46x5r7v6ueeFvDpnzNqB9wodeF_D-AKD0MLgMsfflySnVCmkeg97tXQili7gL_7_3ANAvj0w</recordid><startdate>20030123</startdate><enddate>20030123</enddate><creator>Belfort, Michael A</creator><creator>Anthony, John</creator><creator>Saade, George R</creator><creator>Allen, John C</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030123</creationdate><title>A Comparison of Magnesium Sulfate and Nimodipine for the Prevention of Eclampsia</title><author>Belfort, Michael A ; Anthony, John ; Saade, George R ; Allen, John C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-7d999d3ae5b2cabf20fe7dcd9137241f43add1eea9314ef666a2f0e2289ad2783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anticonvulsants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Eclampsia - prevention & control</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Logistic Models</topic><topic>Magnesium Sulfate - therapeutic use</topic><topic>Medical sciences</topic><topic>Nifedipine - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Pre-Eclampsia - drug therapy</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Risk</topic><topic>Seizures - prevention & control</topic><topic>Vasodilator Agents - therapeutic use</topic><topic>Vasospasm, Intracranial - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belfort, Michael A</creatorcontrib><creatorcontrib>Anthony, John</creatorcontrib><creatorcontrib>Saade, George R</creatorcontrib><creatorcontrib>Allen, John C</creatorcontrib><creatorcontrib>Nimodipine Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belfort, Michael A</au><au>Anthony, John</au><au>Saade, George R</au><au>Allen, John C</au><aucorp>Nimodipine Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of Magnesium Sulfate and Nimodipine for the Prevention of Eclampsia</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2003-01-23</date><risdate>2003</risdate><volume>348</volume><issue>4</issue><spage>304</spage><epage>311</epage><pages>304-311</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In this randomized, unblinded, multicenter study, magnesium sulfate proved more effective than nimodipine, a cerebral vasodilator, in preventing seizures in women with severe preeclampsia. The risk of seizure was three times as high in the group given nimodipine as in the group given magnesium sulfate.
The risk of seizure was higher in the nimodipine group.
Cerebral infarction and hemorrhage still account for the majority of deaths from eclampsia and preeclampsia.
1
,
2
Preeclampsia causes regional vasoconstriction, and many believe that eclampsia results from cerebral vasospasm and resultant ischemia.
3
–
6
Magnesium sulfate is generally accepted as the treatment of choice for eclampsia.
7
–
9
The use of magnesium sulfate to prevent eclampsia has been common in the United States for decades
10
,
11
but has not been internationally adopted. The placebo-controlled Magnesium Sulphate for Prevention of Eclampsia (MAGPIE) trial
12
recently confirmed the prophylactic action of magnesium sulfate and is likely to increase the use of this agent in women . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>12540643</pmid><doi>10.1056/NEJMoa021180</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Anticonvulsants - therapeutic use Biological and medical sciences Calcium Channel Blockers - therapeutic use Drug dosages Drug therapy Eclampsia - prevention & control Female Genital system. Reproduction Humans Ischemia Logistic Models Magnesium Sulfate - therapeutic use Medical sciences Nifedipine - therapeutic use Pharmacology. Drug treatments Pre-Eclampsia - drug therapy Preeclampsia Pregnancy Risk Seizures - prevention & control Vasodilator Agents - therapeutic use Vasospasm, Intracranial - prevention & control |
| title | A Comparison of Magnesium Sulfate and Nimodipine for the Prevention of Eclampsia |
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