Effect of experimental hemorrhagic shock on hepatic drug elimination

OBJECTIVE:Exogenous substrates were used to measure hepatic function for the purposes of determining organ dysfunction and to evaluate the effect of experimental hemorrhagic shock with resuscitation on hepatic drug elimination. DESIGN:Prospective, controlled, non-randomized crossover trial. INTERVEN...

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Veröffentlicht in:	Critical care medicine 1992-06, Vol.20 (6), p.810-815
Hauptverfasser:	DiPIRO, JOSEPH T, HOOKER, K DALE, SHERMAN, JAMES C, GAINES, MICHAEL G, WYNN, JAMES J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipyrine - blood Antipyrine - pharmacokinetics Biological and medical sciences Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Disease Models, Animal Female General pharmacology Half-Life Indocyanine Green - analysis Indocyanine Green - pharmacokinetics Liver - metabolism Lorazepam - blood Lorazepam - pharmacokinetics Male Medical sciences Metabolic Clearance Rate Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Shock, Hemorrhagic - blood Spectrophotometry, Ultraviolet Swine Time Factors
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