A reevaluation of estrogen status in postmenopausal women who smoke
Hypoestrogenism in postmenopausal smokers has been suggested as the mechanism for the observed decreased risk of endometrial cancer and increased risk of osteoporosis. We have prospectively studied a well-matched group of smokers and nonsmokers and have evaluated their estrogen levels and compared t...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1992-05, Vol.166 (5), p.1444-1448 |
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| container_issue | 5 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 166 |
| creator | Cassidenti, Denise Lee Pike, Malcolm C. Vijod, Ariel G. Stanczyk, Frank Z. Lobo, Rogerio A. |
| description | Hypoestrogenism in postmenopausal smokers has been suggested as the mechanism for the observed decreased risk of endometrial cancer and increased risk of osteoporosis. We have prospectively studied a well-matched group of smokers and nonsmokers and have evaluated their estrogen levels and compared them with existing data from the literature. We conclude that increased adrenal activity resulting in increased androgens, mainly androstenedione, is seen in postmenopausal smokers but that estrogen levels are not decreased. We hypothesize that in nonusers, unlike in users of estrogen, smoking is not associated with changes in estrogen levels and that other mechanisms must be responsible for the epidemiologic observations seen. |
| doi_str_mv | 10.1016/0002-9378(92)91617-J |
| format | Article |
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We have prospectively studied a well-matched group of smokers and nonsmokers and have evaluated their estrogen levels and compared them with existing data from the literature. We conclude that increased adrenal activity resulting in increased androgens, mainly androstenedione, is seen in postmenopausal smokers but that estrogen levels are not decreased. We hypothesize that in nonusers, unlike in users of estrogen, smoking is not associated with changes in estrogen levels and that other mechanisms must be responsible for the epidemiologic observations seen.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(92)91617-J</identifier><identifier>PMID: 1534446</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Aged ; Androstenedione - blood ; Biological and medical sciences ; Dehydroepiandrosterone - analogs & derivatives ; Dehydroepiandrosterone - blood ; Dehydroepiandrosterone Sulfate ; Estradiol - blood ; Estrogens - blood ; Estrone - blood ; Female ; Fundamental and applied biological sciences. Psychology ; hormonal status ; Hormone metabolism and regulation ; Humans ; Hydrocortisone - blood ; Mammalian female genital system ; postmenopausal women ; Prospective Studies ; Sex Hormone-Binding Globulin - metabolism ; Smoking ; Smoking - blood ; Vertebrates: reproduction</subject><ispartof>American journal of obstetrics and gynecology, 1992-05, Vol.166 (5), p.1444-1448</ispartof><rights>1992 Mosby</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-6f9ad8bdef4554ff9a3a5bc3305da6ffae80fa60b2cad77afd50455bb966cb893</citedby><cites>FETCH-LOGICAL-c417t-6f9ad8bdef4554ff9a3a5bc3305da6ffae80fa60b2cad77afd50455bb966cb893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000293789291617J$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4385273$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1534446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cassidenti, Denise Lee</creatorcontrib><creatorcontrib>Pike, Malcolm C.</creatorcontrib><creatorcontrib>Vijod, Ariel G.</creatorcontrib><creatorcontrib>Stanczyk, Frank Z.</creatorcontrib><creatorcontrib>Lobo, Rogerio A.</creatorcontrib><title>A reevaluation of estrogen status in postmenopausal women who smoke</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Hypoestrogenism in postmenopausal smokers has been suggested as the mechanism for the observed decreased risk of endometrial cancer and increased risk of osteoporosis. We have prospectively studied a well-matched group of smokers and nonsmokers and have evaluated their estrogen levels and compared them with existing data from the literature. We conclude that increased adrenal activity resulting in increased androgens, mainly androstenedione, is seen in postmenopausal smokers but that estrogen levels are not decreased. We hypothesize that in nonusers, unlike in users of estrogen, smoking is not associated with changes in estrogen levels and that other mechanisms must be responsible for the epidemiologic observations seen.</description><subject>Aged</subject><subject>Androstenedione - blood</subject><subject>Biological and medical sciences</subject><subject>Dehydroepiandrosterone - analogs & derivatives</subject><subject>Dehydroepiandrosterone - blood</subject><subject>Dehydroepiandrosterone Sulfate</subject><subject>Estradiol - blood</subject><subject>Estrogens - blood</subject><subject>Estrone - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hormonal status</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Mammalian female genital system</subject><subject>postmenopausal women</subject><subject>Prospective Studies</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>Smoking</subject><subject>Smoking - blood</subject><subject>Vertebrates: reproduction</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVo2G7S_IMUdCglOTiV_CFZl8Ky5JNALulZjOVRqta2tpK9If--Mrtsb81peJlnhpeHkHPOrjjj4htjLM9UIesLlV8qLrjMHo7IkjMlM1GL-gNZHpCP5CTGX3PMVb4gC14VZVmKJVmvaEDcQjfB6PxAvaUYx-BfcKBxhHGK1A104-PY4-A3MEXo6KtPgb7-9DT2_jd-IscWuohn-3lKftxcP6_vssen2_v16jEzJZdjJqyCtm5atGVVlTalAqrGFAWrWhDWAtbMgmBNbqCVEmxbsUQ2jRLCNLUqTsnX3d9N8H-mVFP3LhrsOhjQT1HLXEkuVPUuyEUuC5nXCSx3oAk-xoBWb4LrIbxpzvQsWc_K9GxQqzRnyfohnX3e_5-aHtt_Rzuraf9lv4dooLMBBuPiASuLukoFEvZ9h2GStnUYdDQOB4OtC2hG3Xr3_x5_AXiHmXY</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Cassidenti, Denise Lee</creator><creator>Pike, Malcolm C.</creator><creator>Vijod, Ariel G.</creator><creator>Stanczyk, Frank Z.</creator><creator>Lobo, Rogerio A.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TK</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>A reevaluation of estrogen status in postmenopausal women who smoke</title><author>Cassidenti, Denise Lee ; Pike, Malcolm C. ; Vijod, Ariel G. ; Stanczyk, Frank Z. ; Lobo, Rogerio A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-6f9ad8bdef4554ff9a3a5bc3305da6ffae80fa60b2cad77afd50455bb966cb893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aged</topic><topic>Androstenedione - blood</topic><topic>Biological and medical sciences</topic><topic>Dehydroepiandrosterone - analogs & derivatives</topic><topic>Dehydroepiandrosterone - blood</topic><topic>Dehydroepiandrosterone Sulfate</topic><topic>Estradiol - blood</topic><topic>Estrogens - blood</topic><topic>Estrone - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hormonal status</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Mammalian female genital system</topic><topic>postmenopausal women</topic><topic>Prospective Studies</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>Smoking</topic><topic>Smoking - blood</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cassidenti, Denise Lee</creatorcontrib><creatorcontrib>Pike, Malcolm C.</creatorcontrib><creatorcontrib>Vijod, Ariel G.</creatorcontrib><creatorcontrib>Stanczyk, Frank Z.</creatorcontrib><creatorcontrib>Lobo, Rogerio A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cassidenti, Denise Lee</au><au>Pike, Malcolm C.</au><au>Vijod, Ariel G.</au><au>Stanczyk, Frank Z.</au><au>Lobo, Rogerio A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A reevaluation of estrogen status in postmenopausal women who smoke</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>166</volume><issue>5</issue><spage>1444</spage><epage>1448</epage><pages>1444-1448</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Hypoestrogenism in postmenopausal smokers has been suggested as the mechanism for the observed decreased risk of endometrial cancer and increased risk of osteoporosis. We have prospectively studied a well-matched group of smokers and nonsmokers and have evaluated their estrogen levels and compared them with existing data from the literature. We conclude that increased adrenal activity resulting in increased androgens, mainly androstenedione, is seen in postmenopausal smokers but that estrogen levels are not decreased. We hypothesize that in nonusers, unlike in users of estrogen, smoking is not associated with changes in estrogen levels and that other mechanisms must be responsible for the epidemiologic observations seen.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>1534446</pmid><doi>10.1016/0002-9378(92)91617-J</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1992-05, Vol.166 (5), p.1444-1448 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Androstenedione - blood Biological and medical sciences Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - blood Dehydroepiandrosterone Sulfate Estradiol - blood Estrogens - blood Estrone - blood Female Fundamental and applied biological sciences. Psychology hormonal status Hormone metabolism and regulation Humans Hydrocortisone - blood Mammalian female genital system postmenopausal women Prospective Studies Sex Hormone-Binding Globulin - metabolism Smoking Smoking - blood Vertebrates: reproduction |
| title | A reevaluation of estrogen status in postmenopausal women who smoke |
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