Testicular Function in Hyperthyroidism
Testicular function was assessed in nine men aged 17 to 35 years and seven men aged 36 to 46 years with Graves' disease. Levels of total testosterone, estradiol, sex hormone binding globulin, luteinizing hormone, and follicle stimulating hormone, and gonadotropin responses to gonadotropin relea...
Gespeichert in:
| Veröffentlicht in: | Journal of andrology 1992-03, Vol.13 (2), p.117-124 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 124 |
|---|---|
| container_issue | 2 |
| container_start_page | 117 |
| container_title | Journal of andrology |
| container_volume | 13 |
| creator | HUDSON, ROBERT W. EDWARDS, ALUN L. |
| description | Testicular function was assessed in nine men aged 17 to 35 years and seven men aged 36 to 46 years with Graves' disease. Levels of total testosterone, estradiol, sex hormone binding globulin, luteinizing hormone, and follicle stimulating hormone, and gonadotropin responses to gonadotropin releasing hormone were significantly greater than these levels and responses in age‐matched controls. Although the percentage of free testosterone was lower than control values in the hyperthyroid men, calculated levels of free testosterone were not different from normal. Lower than normal percentages of free estradiol values resulted in higher than normal calculated free estradiol levels. As a result, the free testosterone/free estradiol ratio in the men with Graves' disease was lower than normal. Although mean sperm densities in the hyperthyroid men were not different from control values, the percent forward progressive motility of sperm from these men was significantly lower than control values. The hormonal and seminal abnormalities corrected when the patients became euthyroid after radioiodine therapy. The results of this study indicate that hyperthyroid men may have abnormalities in their hypothalamic‐pituitary‐testicular axes. |
| doi_str_mv | 10.1002/j.1939-4640.1992.tb01641.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72969713</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72969713</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4521-879394e4ee41e661163421e19cf1b7fe57d05ccd73483a5df8e69ea08350bc7d3</originalsourceid><addsrcrecordid>eNqVkEtLAzEUhYMotVZ_glBEupsxd5JJGleWan1QdFPXIZPJYMo8atLB9t-bYUpdu8ol55z7-BC6ARwDxsndOgZBREQZDR9CJPE2w8AoxLsTNDxKp2iIQbCIMJKeowvv1yGLgZMBGkAqOBHpEE1Wxm-tbkvlxou21lvb1GNbj1_2G-O2X3vX2Nz66hKdFar05urwjtDn4mk1f4mWH8-v89ky0jRNIJryMJwaagwFwxgAIzQBA0IXkPHCpDzHqdY5J3RKVJoXU8OEUXhKUpxpnpMRmvR9N675bsNqsrJem7JUtWlaL3kimOBAgvG-N2rXeO9MITfOVsrtJWDZQZJr2ZGQHQnZQZIHSHIXwteHKW1Wmfwv2lMJ-u1BV16rsnCq1tYfbZRyHA4Ntofe9mNLs__HAvJt9v7YleQXvkODAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72969713</pqid></control><display><type>article</type><title>Testicular Function in Hyperthyroidism</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>HUDSON, ROBERT W. ; EDWARDS, ALUN L.</creator><creatorcontrib>HUDSON, ROBERT W. ; EDWARDS, ALUN L.</creatorcontrib><description>Testicular function was assessed in nine men aged 17 to 35 years and seven men aged 36 to 46 years with Graves' disease. Levels of total testosterone, estradiol, sex hormone binding globulin, luteinizing hormone, and follicle stimulating hormone, and gonadotropin responses to gonadotropin releasing hormone were significantly greater than these levels and responses in age‐matched controls. Although the percentage of free testosterone was lower than control values in the hyperthyroid men, calculated levels of free testosterone were not different from normal. Lower than normal percentages of free estradiol values resulted in higher than normal calculated free estradiol levels. As a result, the free testosterone/free estradiol ratio in the men with Graves' disease was lower than normal. Although mean sperm densities in the hyperthyroid men were not different from control values, the percent forward progressive motility of sperm from these men was significantly lower than control values. The hormonal and seminal abnormalities corrected when the patients became euthyroid after radioiodine therapy. The results of this study indicate that hyperthyroid men may have abnormalities in their hypothalamic‐pituitary‐testicular axes.</description><identifier>ISSN: 0196-3635</identifier><identifier>EISSN: 1939-4640</identifier><identifier>DOI: 10.1002/j.1939-4640.1992.tb01641.x</identifier><identifier>PMID: 1597395</identifier><identifier>CODEN: JOAND3</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Endocrinopathies ; Estradiol - blood ; Follicle Stimulating Hormone - blood ; Gonadotropin-Releasing Hormone - pharmacology ; gonadotropins ; Humans ; Hyperthyroidism - blood ; Hyperthyroidism - drug therapy ; Hyperthyroidism - physiopathology ; Luteinizing Hormone - blood ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Prolactin - blood ; Propranolol - therapeutic use ; Sex Hormone-Binding Globulin - analysis ; Sperm Count - drug effects ; sperm motility ; Sperm Motility - drug effects ; Testis - physiology ; Testosterone ; Testosterone - blood ; Thyroid Gland - drug effects ; Thyroid Gland - metabolism ; Thyroid Gland - physiology ; Thyroid. Thyroid axis (diseases) ; Thyrotropin-Releasing Hormone - pharmacology</subject><ispartof>Journal of andrology, 1992-03, Vol.13 (2), p.117-124</ispartof><rights>1992 American Society of Andrology</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4521-879394e4ee41e661163421e19cf1b7fe57d05ccd73483a5df8e69ea08350bc7d3</citedby><cites>FETCH-LOGICAL-c4521-879394e4ee41e661163421e19cf1b7fe57d05ccd73483a5df8e69ea08350bc7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4470793$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1597395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HUDSON, ROBERT W.</creatorcontrib><creatorcontrib>EDWARDS, ALUN L.</creatorcontrib><title>Testicular Function in Hyperthyroidism</title><title>Journal of andrology</title><addtitle>J Androl</addtitle><description>Testicular function was assessed in nine men aged 17 to 35 years and seven men aged 36 to 46 years with Graves' disease. Levels of total testosterone, estradiol, sex hormone binding globulin, luteinizing hormone, and follicle stimulating hormone, and gonadotropin responses to gonadotropin releasing hormone were significantly greater than these levels and responses in age‐matched controls. Although the percentage of free testosterone was lower than control values in the hyperthyroid men, calculated levels of free testosterone were not different from normal. Lower than normal percentages of free estradiol values resulted in higher than normal calculated free estradiol levels. As a result, the free testosterone/free estradiol ratio in the men with Graves' disease was lower than normal. Although mean sperm densities in the hyperthyroid men were not different from control values, the percent forward progressive motility of sperm from these men was significantly lower than control values. The hormonal and seminal abnormalities corrected when the patients became euthyroid after radioiodine therapy. The results of this study indicate that hyperthyroid men may have abnormalities in their hypothalamic‐pituitary‐testicular axes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrinopathies</subject><subject>Estradiol - blood</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>gonadotropins</subject><subject>Humans</subject><subject>Hyperthyroidism - blood</subject><subject>Hyperthyroidism - drug therapy</subject><subject>Hyperthyroidism - physiopathology</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Prolactin - blood</subject><subject>Propranolol - therapeutic use</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Sperm Count - drug effects</subject><subject>sperm motility</subject><subject>Sperm Motility - drug effects</subject><subject>Testis - physiology</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - physiology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyrotropin-Releasing Hormone - pharmacology</subject><issn>0196-3635</issn><issn>1939-4640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtLAzEUhYMotVZ_glBEupsxd5JJGleWan1QdFPXIZPJYMo8atLB9t-bYUpdu8ol55z7-BC6ARwDxsndOgZBREQZDR9CJPE2w8AoxLsTNDxKp2iIQbCIMJKeowvv1yGLgZMBGkAqOBHpEE1Wxm-tbkvlxou21lvb1GNbj1_2G-O2X3vX2Nz66hKdFar05urwjtDn4mk1f4mWH8-v89ky0jRNIJryMJwaagwFwxgAIzQBA0IXkPHCpDzHqdY5J3RKVJoXU8OEUXhKUpxpnpMRmvR9N675bsNqsrJem7JUtWlaL3kimOBAgvG-N2rXeO9MITfOVsrtJWDZQZJr2ZGQHQnZQZIHSHIXwteHKW1Wmfwv2lMJ-u1BV16rsnCq1tYfbZRyHA4Ntofe9mNLs__HAvJt9v7YleQXvkODAg</recordid><startdate>199203</startdate><enddate>199203</enddate><creator>HUDSON, ROBERT W.</creator><creator>EDWARDS, ALUN L.</creator><general>Blackwell Publishing Ltd</general><general>American Society of Andrology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199203</creationdate><title>Testicular Function in Hyperthyroidism</title><author>HUDSON, ROBERT W. ; EDWARDS, ALUN L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4521-879394e4ee41e661163421e19cf1b7fe57d05ccd73483a5df8e69ea08350bc7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endocrinopathies</topic><topic>Estradiol - blood</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>gonadotropins</topic><topic>Humans</topic><topic>Hyperthyroidism - blood</topic><topic>Hyperthyroidism - drug therapy</topic><topic>Hyperthyroidism - physiopathology</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Prolactin - blood</topic><topic>Propranolol - therapeutic use</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Sperm Count - drug effects</topic><topic>sperm motility</topic><topic>Sperm Motility - drug effects</topic><topic>Testis - physiology</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - physiology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyrotropin-Releasing Hormone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HUDSON, ROBERT W.</creatorcontrib><creatorcontrib>EDWARDS, ALUN L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of andrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUDSON, ROBERT W.</au><au>EDWARDS, ALUN L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testicular Function in Hyperthyroidism</atitle><jtitle>Journal of andrology</jtitle><addtitle>J Androl</addtitle><date>1992-03</date><risdate>1992</risdate><volume>13</volume><issue>2</issue><spage>117</spage><epage>124</epage><pages>117-124</pages><issn>0196-3635</issn><eissn>1939-4640</eissn><coden>JOAND3</coden><abstract>Testicular function was assessed in nine men aged 17 to 35 years and seven men aged 36 to 46 years with Graves' disease. Levels of total testosterone, estradiol, sex hormone binding globulin, luteinizing hormone, and follicle stimulating hormone, and gonadotropin responses to gonadotropin releasing hormone were significantly greater than these levels and responses in age‐matched controls. Although the percentage of free testosterone was lower than control values in the hyperthyroid men, calculated levels of free testosterone were not different from normal. Lower than normal percentages of free estradiol values resulted in higher than normal calculated free estradiol levels. As a result, the free testosterone/free estradiol ratio in the men with Graves' disease was lower than normal. Although mean sperm densities in the hyperthyroid men were not different from control values, the percent forward progressive motility of sperm from these men was significantly lower than control values. The hormonal and seminal abnormalities corrected when the patients became euthyroid after radioiodine therapy. The results of this study indicate that hyperthyroid men may have abnormalities in their hypothalamic‐pituitary‐testicular axes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1597395</pmid><doi>10.1002/j.1939-4640.1992.tb01641.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-3635 |
| ispartof | Journal of andrology, 1992-03, Vol.13 (2), p.117-124 |
| issn | 0196-3635 1939-4640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72969713 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Biological and medical sciences Dose-Response Relationship, Drug Endocrinopathies Estradiol - blood Follicle Stimulating Hormone - blood Gonadotropin-Releasing Hormone - pharmacology gonadotropins Humans Hyperthyroidism - blood Hyperthyroidism - drug therapy Hyperthyroidism - physiopathology Luteinizing Hormone - blood Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Prolactin - blood Propranolol - therapeutic use Sex Hormone-Binding Globulin - analysis Sperm Count - drug effects sperm motility Sperm Motility - drug effects Testis - physiology Testosterone Testosterone - blood Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid Gland - physiology Thyroid. Thyroid axis (diseases) Thyrotropin-Releasing Hormone - pharmacology |
| title | Testicular Function in Hyperthyroidism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T19%3A58%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Testicular%20Function%20in%20Hyperthyroidism&rft.jtitle=Journal%20of%20andrology&rft.au=HUDSON,%20ROBERT%20W.&rft.date=1992-03&rft.volume=13&rft.issue=2&rft.spage=117&rft.epage=124&rft.pages=117-124&rft.issn=0196-3635&rft.eissn=1939-4640&rft.coden=JOAND3&rft_id=info:doi/10.1002/j.1939-4640.1992.tb01641.x&rft_dat=%3Cproquest_cross%3E72969713%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72969713&rft_id=info:pmid/1597395&rfr_iscdi=true |