Dexanabinol (HU-211) has a beneficial effect on axonal sprouting and survival after rat optic nerve crush injury
Dexanabinol (HU-211) is a synthetic non-psychotropic cannabinoid and a non-competitive NMDA-receptor antagonist. The beneficial effect of dexanabinol on prevention of degeneration and promotion of regeneration was studied on the crush-injured rat optic nerve model. Sprague–Dawley rats were subjected...
Gespeichert in:
| Veröffentlicht in: | Vision research (Oxford) 2003-02, Vol.43 (3), p.237-242 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 242 |
|---|---|
| container_issue | 3 |
| container_start_page | 237 |
| container_title | Vision research (Oxford) |
| container_volume | 43 |
| creator | Zalish, M. Lavie, V. |
| description | Dexanabinol (HU-211) is a synthetic non-psychotropic cannabinoid and a non-competitive NMDA-receptor antagonist. The beneficial effect of dexanabinol on prevention of degeneration and promotion of regeneration was studied on the crush-injured rat optic nerve model. Sprague–Dawley rats were subjected to a calibrated crush injury of the optic nerve and treated with a single intraperitoneal injection of dexanabinol (7 mg/kg), its vehicle only or were untreated. Transmission electron microscopic analysis of the excised optic nerves was performed after 30 days. In the dexanabinol treated rats, the site of injury was traversed by unmyelinated and thinly myelinated axons, possibly indicative of regenerative growth. No such growth was detectable in the controls. Viable axons were found 0.5 mm distal to the site of injury in 6 of 8 dexanabinol treated rats, but in only 1 of 10 rats in the control groups.
These results have clinical implications for the prevention of secondary degeneration and promotion of regeneration after injuries to the central nervous system. |
| doi_str_mv | 10.1016/S0042-6989(02)00494-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72969676</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0042698902004947</els_id><sourcerecordid>72969676</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-1be947da8d6d3a3f9d7aa85a04d19f4a28a889f7cc17643e8f0dc7c856970a413</originalsourceid><addsrcrecordid>eNqFkE1PHDEMhqOqVVlofwJVLq3gMG0yk8nHqar4rITEgXKOvIkDQbOZbTKzgn_fwK7g2JNl67H96iHkkLPvnHH544Yx0TbSaHPE2uPaGNGod2TBtdJNL4V8TxavyB7ZL-WBMab61nwke7ztu97obkHWp_gICZYxjQM9urxtWs6P6T0UCnSJCUN0EQaKIaCb6JgoPI6pDso6j_MU0x2F5GmZ8yZu6hjChJlmqOh6io4mzBukLs_lnsb0MOenT-RDgKHg5109ILfnZ39OLpur64vfJ7-uGtcZPjV8iUYoD9pL30EXjFcAugcmPDdBQKtBaxOUc1xJ0aEOzDvldC-NYiB4d0C-be_WoH9nLJNdxeJwGCDhOBerWiONVLKC_RZ0eSwlY7DrHFeQnyxn9lm1fVFtnz1a1toX1VbVvS-7B_Nyhf5ta-e2Al93ABQHQ8iQXCxvnBBK6M5U7ueWw6pjEzHb4iImhz7mKt36Mf4nyj_DnptG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72969676</pqid></control><display><type>article</type><title>Dexanabinol (HU-211) has a beneficial effect on axonal sprouting and survival after rat optic nerve crush injury</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Zalish, M. ; Lavie, V.</creator><creatorcontrib>Zalish, M. ; Lavie, V.</creatorcontrib><description>Dexanabinol (HU-211) is a synthetic non-psychotropic cannabinoid and a non-competitive NMDA-receptor antagonist. The beneficial effect of dexanabinol on prevention of degeneration and promotion of regeneration was studied on the crush-injured rat optic nerve model. Sprague–Dawley rats were subjected to a calibrated crush injury of the optic nerve and treated with a single intraperitoneal injection of dexanabinol (7 mg/kg), its vehicle only or were untreated. Transmission electron microscopic analysis of the excised optic nerves was performed after 30 days. In the dexanabinol treated rats, the site of injury was traversed by unmyelinated and thinly myelinated axons, possibly indicative of regenerative growth. No such growth was detectable in the controls. Viable axons were found 0.5 mm distal to the site of injury in 6 of 8 dexanabinol treated rats, but in only 1 of 10 rats in the control groups.
These results have clinical implications for the prevention of secondary degeneration and promotion of regeneration after injuries to the central nervous system.</description><identifier>ISSN: 0042-6989</identifier><identifier>EISSN: 1878-5646</identifier><identifier>DOI: 10.1016/S0042-6989(02)00494-7</identifier><identifier>PMID: 12535983</identifier><identifier>CODEN: VISRAM</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Axons - drug effects ; Axons - ultrastructure ; Biological and medical sciences ; Cell Survival - drug effects ; Degeneration ; Dexanabinol ; Dronabinol - analogs & derivatives ; Dronabinol - therapeutic use ; Excitatory Amino Acid Antagonists - therapeutic use ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Male ; Microscopy, Electron ; Nerve Degeneration ; Nerve Regeneration - drug effects ; Neuroprotective Agents - therapeutic use ; NMDA receptor antagonist ; Optic nerve ; Optic Nerve - ultrastructure ; Optic Nerve Injuries - drug therapy ; Optic Nerve Injuries - pathology ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Regeneration ; Vertebrates: nervous system and sense organs</subject><ispartof>Vision research (Oxford), 2003-02, Vol.43 (3), p.237-242</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-1be947da8d6d3a3f9d7aa85a04d19f4a28a889f7cc17643e8f0dc7c856970a413</citedby><cites>FETCH-LOGICAL-c391t-1be947da8d6d3a3f9d7aa85a04d19f4a28a889f7cc17643e8f0dc7c856970a413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0042698902004947$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14474839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12535983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zalish, M.</creatorcontrib><creatorcontrib>Lavie, V.</creatorcontrib><title>Dexanabinol (HU-211) has a beneficial effect on axonal sprouting and survival after rat optic nerve crush injury</title><title>Vision research (Oxford)</title><addtitle>Vision Res</addtitle><description>Dexanabinol (HU-211) is a synthetic non-psychotropic cannabinoid and a non-competitive NMDA-receptor antagonist. The beneficial effect of dexanabinol on prevention of degeneration and promotion of regeneration was studied on the crush-injured rat optic nerve model. Sprague–Dawley rats were subjected to a calibrated crush injury of the optic nerve and treated with a single intraperitoneal injection of dexanabinol (7 mg/kg), its vehicle only or were untreated. Transmission electron microscopic analysis of the excised optic nerves was performed after 30 days. In the dexanabinol treated rats, the site of injury was traversed by unmyelinated and thinly myelinated axons, possibly indicative of regenerative growth. No such growth was detectable in the controls. Viable axons were found 0.5 mm distal to the site of injury in 6 of 8 dexanabinol treated rats, but in only 1 of 10 rats in the control groups.
These results have clinical implications for the prevention of secondary degeneration and promotion of regeneration after injuries to the central nervous system.</description><subject>Animals</subject><subject>Axons - drug effects</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Degeneration</subject><subject>Dexanabinol</subject><subject>Dronabinol - analogs & derivatives</subject><subject>Dronabinol - therapeutic use</subject><subject>Excitatory Amino Acid Antagonists - therapeutic use</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Nerve Degeneration</subject><subject>Nerve Regeneration - drug effects</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>NMDA receptor antagonist</subject><subject>Optic nerve</subject><subject>Optic Nerve - ultrastructure</subject><subject>Optic Nerve Injuries - drug therapy</subject><subject>Optic Nerve Injuries - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Regeneration</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0042-6989</issn><issn>1878-5646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PHDEMhqOqVVlofwJVLq3gMG0yk8nHqar4rITEgXKOvIkDQbOZbTKzgn_fwK7g2JNl67H96iHkkLPvnHH544Yx0TbSaHPE2uPaGNGod2TBtdJNL4V8TxavyB7ZL-WBMab61nwke7ztu97obkHWp_gICZYxjQM9urxtWs6P6T0UCnSJCUN0EQaKIaCb6JgoPI6pDso6j_MU0x2F5GmZ8yZu6hjChJlmqOh6io4mzBukLs_lnsb0MOenT-RDgKHg5109ILfnZ39OLpur64vfJ7-uGtcZPjV8iUYoD9pL30EXjFcAugcmPDdBQKtBaxOUc1xJ0aEOzDvldC-NYiB4d0C-be_WoH9nLJNdxeJwGCDhOBerWiONVLKC_RZ0eSwlY7DrHFeQnyxn9lm1fVFtnz1a1toX1VbVvS-7B_Nyhf5ta-e2Al93ABQHQ8iQXCxvnBBK6M5U7ueWw6pjEzHb4iImhz7mKt36Mf4nyj_DnptG</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Zalish, M.</creator><creator>Lavie, V.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Dexanabinol (HU-211) has a beneficial effect on axonal sprouting and survival after rat optic nerve crush injury</title><author>Zalish, M. ; Lavie, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-1be947da8d6d3a3f9d7aa85a04d19f4a28a889f7cc17643e8f0dc7c856970a413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Axons - drug effects</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Cell Survival - drug effects</topic><topic>Degeneration</topic><topic>Dexanabinol</topic><topic>Dronabinol - analogs & derivatives</topic><topic>Dronabinol - therapeutic use</topic><topic>Excitatory Amino Acid Antagonists - therapeutic use</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Nerve Degeneration</topic><topic>Nerve Regeneration - drug effects</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>NMDA receptor antagonist</topic><topic>Optic nerve</topic><topic>Optic Nerve - ultrastructure</topic><topic>Optic Nerve Injuries - drug therapy</topic><topic>Optic Nerve Injuries - pathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Regeneration</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zalish, M.</creatorcontrib><creatorcontrib>Lavie, V.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vision research (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zalish, M.</au><au>Lavie, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dexanabinol (HU-211) has a beneficial effect on axonal sprouting and survival after rat optic nerve crush injury</atitle><jtitle>Vision research (Oxford)</jtitle><addtitle>Vision Res</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>43</volume><issue>3</issue><spage>237</spage><epage>242</epage><pages>237-242</pages><issn>0042-6989</issn><eissn>1878-5646</eissn><coden>VISRAM</coden><abstract>Dexanabinol (HU-211) is a synthetic non-psychotropic cannabinoid and a non-competitive NMDA-receptor antagonist. The beneficial effect of dexanabinol on prevention of degeneration and promotion of regeneration was studied on the crush-injured rat optic nerve model. Sprague–Dawley rats were subjected to a calibrated crush injury of the optic nerve and treated with a single intraperitoneal injection of dexanabinol (7 mg/kg), its vehicle only or were untreated. Transmission electron microscopic analysis of the excised optic nerves was performed after 30 days. In the dexanabinol treated rats, the site of injury was traversed by unmyelinated and thinly myelinated axons, possibly indicative of regenerative growth. No such growth was detectable in the controls. Viable axons were found 0.5 mm distal to the site of injury in 6 of 8 dexanabinol treated rats, but in only 1 of 10 rats in the control groups.
These results have clinical implications for the prevention of secondary degeneration and promotion of regeneration after injuries to the central nervous system.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12535983</pmid><doi>10.1016/S0042-6989(02)00494-7</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0042-6989 |
| ispartof | Vision research (Oxford), 2003-02, Vol.43 (3), p.237-242 |
| issn | 0042-6989 1878-5646 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72969676 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Axons - drug effects Axons - ultrastructure Biological and medical sciences Cell Survival - drug effects Degeneration Dexanabinol Dronabinol - analogs & derivatives Dronabinol - therapeutic use Excitatory Amino Acid Antagonists - therapeutic use Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Male Microscopy, Electron Nerve Degeneration Nerve Regeneration - drug effects Neuroprotective Agents - therapeutic use NMDA receptor antagonist Optic nerve Optic Nerve - ultrastructure Optic Nerve Injuries - drug therapy Optic Nerve Injuries - pathology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Regeneration Vertebrates: nervous system and sense organs |
| title | Dexanabinol (HU-211) has a beneficial effect on axonal sprouting and survival after rat optic nerve crush injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T06%3A07%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dexanabinol%20(HU-211)%20has%20a%20beneficial%20effect%20on%20axonal%20sprouting%20and%20survival%20after%20rat%20optic%20nerve%20crush%20injury&rft.jtitle=Vision%20research%20(Oxford)&rft.au=Zalish,%20M.&rft.date=2003-02-01&rft.volume=43&rft.issue=3&rft.spage=237&rft.epage=242&rft.pages=237-242&rft.issn=0042-6989&rft.eissn=1878-5646&rft.coden=VISRAM&rft_id=info:doi/10.1016/S0042-6989(02)00494-7&rft_dat=%3Cproquest_cross%3E72969676%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72969676&rft_id=info:pmid/12535983&rft_els_id=S0042698902004947&rfr_iscdi=true |