Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

The SH2 domain-containing inositol 5'-phosphatase (SHIP) is crucial in hematopoietic development. To evaluate the possible tumor suppressor role of the SHIP gene in myeloid leukemogenesis, we examined primary leukemia cells from 30 acute myeloid leukemia (AML) patients, together with eight myel...

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Veröffentlicht in:	Leukemia 2003, Vol.17 (1), p.1-8
Hauptverfasser:	LUO, J-M, YOSHIDA, H, NAOE, T, AKAO, Y, OHNO, R, OHNISHI, K, KOMURA, S, OHISHI, N, PAN, L, SHIGENO, K, HANAMURA, I, MIURA, K, LIDA, S, UEDA, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Biological and medical sciences Case-Control Studies Cercopithecus aethiops COS Cells Drug Resistance, Neoplasm Etoposide - pharmacology Genes, Dominant - genetics Hematologic and hematopoietic diseases Humans In Vitro Techniques Interleukin-3 - metabolism Leukemia, Myeloid - genetics Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mutation Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Phosphorylation src Homology Domains - genetics Transfection Tumor Cells, Cultured
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