Evaluation of neoadjuvant chemotherapeutic response of breast cancer using dynamic MRI with high temporal resolution
The aim of this study was to evaluate changes in both size and contrast enhancement of breast tumors during neoadjuvant chemotherapy, using dynamic MRI with high temporal resolution. Patients with advanced breast cancer (n=21) underwent a 1.5-T MRI scan prior to and following neoadjuvant chemotherap...
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| Veröffentlicht in: | European radiology 2003-01, Vol.13 (1), p.80-87 |
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| creator | Wasser, K Klein, S K Fink, C Junkermann, H Sinn, H P Zuna, I Knopp, M V Delorme, S |
| description | The aim of this study was to evaluate changes in both size and contrast enhancement of breast tumors during neoadjuvant chemotherapy, using dynamic MRI with high temporal resolution. Patients with advanced breast cancer (n=21) underwent a 1.5-T MRI scan prior to and following neoadjuvant chemotherapy with four cycles. Dynamic contrast enhancement was measured using a fast turbo-FLASH sequence and quantified using a two-compartment model with the parameters k(ep) and amplitude. Image analysis was done on images overlayed with a color map of parameters. The correlation between tumor diameter measured by histopathology and MRI was 0.7 (p |
| doi_str_mv | 10.1007/s00330-002-1654-1 |
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Patients with advanced breast cancer (n=21) underwent a 1.5-T MRI scan prior to and following neoadjuvant chemotherapy with four cycles. Dynamic contrast enhancement was measured using a fast turbo-FLASH sequence and quantified using a two-compartment model with the parameters k(ep) and amplitude. Image analysis was done on images overlayed with a color map of parameters. The correlation between tumor diameter measured by histopathology and MRI was 0.7 (p<0.003). A reduction of tumor size after chemotherapy of more than 25% was associated with a decrease of both analyzed contrast enhancement parameters (k(ep): p<0.002; amplitude: p<0.006), where k(ep) began to drop already after the first cycle of chemotherapy (p<0.008). A clear reduction of tumor size was only noted after the third cycle (p<0.008). In patients without tumor regression there was also a trend towards an early reduction of contrast enhancement. We assume that MRI with high temporal resolution and color mapping is a novel tool to assess therapeutic effects of neoadjuvant chemotherapy in breast tumors, which deserves further prospective evaluation.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-002-1654-1</identifier><identifier>PMID: 12541113</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - drug therapy ; Breast Neoplasms - surgery ; Cancer therapies ; Chemotherapy ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Mammography ; Middle Aged ; Neoadjuvant Therapy ; Surgery ; Tumors ; Ultrasonic imaging</subject><ispartof>European radiology, 2003-01, Vol.13 (1), p.80-87</ispartof><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-45977e866721a43fe5911dee059176c4e67599e924ac72bfa3e78b62feb90a083</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12541113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wasser, K</creatorcontrib><creatorcontrib>Klein, S K</creatorcontrib><creatorcontrib>Fink, C</creatorcontrib><creatorcontrib>Junkermann, H</creatorcontrib><creatorcontrib>Sinn, H P</creatorcontrib><creatorcontrib>Zuna, I</creatorcontrib><creatorcontrib>Knopp, M V</creatorcontrib><creatorcontrib>Delorme, S</creatorcontrib><title>Evaluation of neoadjuvant chemotherapeutic response of breast cancer using dynamic MRI with high temporal resolution</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>The aim of this study was to evaluate changes in both size and contrast enhancement of breast tumors during neoadjuvant chemotherapy, using dynamic MRI with high temporal resolution. Patients with advanced breast cancer (n=21) underwent a 1.5-T MRI scan prior to and following neoadjuvant chemotherapy with four cycles. Dynamic contrast enhancement was measured using a fast turbo-FLASH sequence and quantified using a two-compartment model with the parameters k(ep) and amplitude. Image analysis was done on images overlayed with a color map of parameters. The correlation between tumor diameter measured by histopathology and MRI was 0.7 (p<0.003). A reduction of tumor size after chemotherapy of more than 25% was associated with a decrease of both analyzed contrast enhancement parameters (k(ep): p<0.002; amplitude: p<0.006), where k(ep) began to drop already after the first cycle of chemotherapy (p<0.008). A clear reduction of tumor size was only noted after the third cycle (p<0.008). In patients without tumor regression there was also a trend towards an early reduction of contrast enhancement. We assume that MRI with high temporal resolution and color mapping is a novel tool to assess therapeutic effects of neoadjuvant chemotherapy in breast tumors, which deserves further prospective evaluation.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - surgery</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Mammography</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1L5TAUhsMww3jV-QGzGcIsZlfNSdKmWYo4KijCoOuQ9p7aXtqmkw_Ff2_KvSC4OgSe93zkIeQnsDNgTJ0HxoRgBWO8gKqUBXwhG5Aiv1gtv5IN06IulNbyiByHsGOMaZDqOzkCXkoAEBsSr17smGwc3ExdR2d0drtLL3aOtO1xcrFHbxdMcWipx7C4OeAKNh5tyIydW_Q0hWF-ptu32U6Zu_93S1-H2NN-eO5pxGlx3o5r3I1pnXRKvnV2DPjjUE_I09-rx8ub4u7h-vby4q5oBZexkKVWCuuqUhysFB2WGmCLyHJVVSuxUqXWqLm0reJNZwWquql4h41mltXihPzZ9128-58wRDMNocVxtPnOFIziutLAZQZ_fwJ3Lvk572aUECJ_Zw0Zgj3UeheCx84sfpisfzPAzOrD7H2Y7MOsPsya-XVonJoJtx-JgwDxDheLhvU</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Wasser, K</creator><creator>Klein, S K</creator><creator>Fink, C</creator><creator>Junkermann, H</creator><creator>Sinn, H P</creator><creator>Zuna, I</creator><creator>Knopp, M V</creator><creator>Delorme, S</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>Evaluation of neoadjuvant chemotherapeutic response of breast cancer using dynamic MRI with high temporal resolution</title><author>Wasser, K ; Klein, S K ; Fink, C ; Junkermann, H ; Sinn, H P ; Zuna, I ; Knopp, M V ; Delorme, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-45977e866721a43fe5911dee059176c4e67599e924ac72bfa3e78b62feb90a083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - surgery</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Mammography</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wasser, K</creatorcontrib><creatorcontrib>Klein, S K</creatorcontrib><creatorcontrib>Fink, C</creatorcontrib><creatorcontrib>Junkermann, H</creatorcontrib><creatorcontrib>Sinn, H P</creatorcontrib><creatorcontrib>Zuna, I</creatorcontrib><creatorcontrib>Knopp, M V</creatorcontrib><creatorcontrib>Delorme, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wasser, K</au><au>Klein, S K</au><au>Fink, C</au><au>Junkermann, H</au><au>Sinn, H P</au><au>Zuna, I</au><au>Knopp, M V</au><au>Delorme, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of neoadjuvant chemotherapeutic response of breast cancer using dynamic MRI with high temporal resolution</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2003-01</date><risdate>2003</risdate><volume>13</volume><issue>1</issue><spage>80</spage><epage>87</epage><pages>80-87</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>The aim of this study was to evaluate changes in both size and contrast enhancement of breast tumors during neoadjuvant chemotherapy, using dynamic MRI with high temporal resolution. Patients with advanced breast cancer (n=21) underwent a 1.5-T MRI scan prior to and following neoadjuvant chemotherapy with four cycles. Dynamic contrast enhancement was measured using a fast turbo-FLASH sequence and quantified using a two-compartment model with the parameters k(ep) and amplitude. Image analysis was done on images overlayed with a color map of parameters. The correlation between tumor diameter measured by histopathology and MRI was 0.7 (p<0.003). A reduction of tumor size after chemotherapy of more than 25% was associated with a decrease of both analyzed contrast enhancement parameters (k(ep): p<0.002; amplitude: p<0.006), where k(ep) began to drop already after the first cycle of chemotherapy (p<0.008). A clear reduction of tumor size was only noted after the third cycle (p<0.008). In patients without tumor regression there was also a trend towards an early reduction of contrast enhancement. We assume that MRI with high temporal resolution and color mapping is a novel tool to assess therapeutic effects of neoadjuvant chemotherapy in breast tumors, which deserves further prospective evaluation.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>12541113</pmid><doi>10.1007/s00330-002-1654-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Breast Neoplasms - surgery Cancer therapies Chemotherapy Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Mammography Middle Aged Neoadjuvant Therapy Surgery Tumors Ultrasonic imaging |
| title | Evaluation of neoadjuvant chemotherapeutic response of breast cancer using dynamic MRI with high temporal resolution |
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