Zebrafish foxi1 mediates otic placode formation and jaw development
The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within otic primordia. Here, we identify a mutation in zebrafish, hears...
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| Veröffentlicht in: | Development (Cambridge) 2003-03, Vol.130 (5), p.929-940 |
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| creator | Solomon, Keely S Kudoh, Tetsuhiro Dawid, Igor B Fritz, Andreas |
| description | The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within otic primordia. Here, we identify a mutation in zebrafish, hearsay , which disrupts the initiation of placode formation. We show that hearsay disrupts foxi1 , a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; foxi1 appears to be the earliest marker known for the otic anlage. We provide evidence that foxi1 regulates expression of pax8 , indicating a very early role for this gene in placode formation. In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos. |
| doi_str_mv | 10.1242/dev.00308 |
| format | Article |
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Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within otic primordia. Here, we identify a mutation in zebrafish, hearsay , which disrupts the initiation of placode formation. We show that hearsay disrupts foxi1 , a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; foxi1 appears to be the earliest marker known for the otic anlage. We provide evidence that foxi1 regulates expression of pax8 , indicating a very early role for this gene in placode formation. In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.00308</identifier><identifier>PMID: 12538519</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Danio rerio ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Ear - embryology ; Embryonic Structures - embryology ; Forkhead Transcription Factors ; foxi1 gene ; Gene Expression Regulation, Developmental ; Humans ; In Situ Hybridization ; Mandible - embryology ; Molecular Sequence Data ; Mutation ; Neural Crest - cytology ; Neural Crest - physiology ; Nuclear Proteins ; Paired Box Transcription Factors ; pax8 protein ; PAX8 Transcription Factor ; Phenotype ; placodes ; Trans-Activators - genetics ; Trans-Activators - metabolism ; Transcription Factors - chemistry ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Zebrafish - anatomy & histology ; Zebrafish - embryology ; Zebrafish - genetics ; Zebrafish Proteins - chemistry ; Zebrafish Proteins - genetics ; Zebrafish Proteins - metabolism</subject><ispartof>Development (Cambridge), 2003-03, Vol.130 (5), p.929-940</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-f30b43acef03d536632f637839f55a93bfe4085e3641416d3d77d82ed8c3f3683</citedby><cites>FETCH-LOGICAL-c389t-f30b43acef03d536632f637839f55a93bfe4085e3641416d3d77d82ed8c3f3683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3679,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12538519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solomon, Keely S</creatorcontrib><creatorcontrib>Kudoh, Tetsuhiro</creatorcontrib><creatorcontrib>Dawid, Igor B</creatorcontrib><creatorcontrib>Fritz, Andreas</creatorcontrib><title>Zebrafish foxi1 mediates otic placode formation and jaw development</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within otic primordia. Here, we identify a mutation in zebrafish, hearsay , which disrupts the initiation of placode formation. We show that hearsay disrupts foxi1 , a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; foxi1 appears to be the earliest marker known for the otic anlage. We provide evidence that foxi1 regulates expression of pax8 , indicating a very early role for this gene in placode formation. 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Kudoh, Tetsuhiro ; Dawid, Igor B ; Fritz, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-f30b43acef03d536632f637839f55a93bfe4085e3641416d3d77d82ed8c3f3683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Danio rerio</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Ear - embryology</topic><topic>Embryonic Structures - embryology</topic><topic>Forkhead Transcription Factors</topic><topic>foxi1 gene</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Mandible - embryology</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - physiology</topic><topic>Nuclear Proteins</topic><topic>Paired Box Transcription Factors</topic><topic>pax8 protein</topic><topic>PAX8 Transcription Factor</topic><topic>Phenotype</topic><topic>placodes</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - metabolism</topic><topic>Transcription Factors - chemistry</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Zebrafish - anatomy & histology</topic><topic>Zebrafish - embryology</topic><topic>Zebrafish - genetics</topic><topic>Zebrafish Proteins - chemistry</topic><topic>Zebrafish Proteins - genetics</topic><topic>Zebrafish Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solomon, Keely S</creatorcontrib><creatorcontrib>Kudoh, Tetsuhiro</creatorcontrib><creatorcontrib>Dawid, Igor B</creatorcontrib><creatorcontrib>Fritz, Andreas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solomon, Keely S</au><au>Kudoh, Tetsuhiro</au><au>Dawid, Igor B</au><au>Fritz, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zebrafish foxi1 mediates otic placode formation and jaw development</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>130</volume><issue>5</issue><spage>929</spage><epage>940</epage><pages>929-940</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within otic primordia. Here, we identify a mutation in zebrafish, hearsay , which disrupts the initiation of placode formation. We show that hearsay disrupts foxi1 , a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; foxi1 appears to be the earliest marker known for the otic anlage. We provide evidence that foxi1 regulates expression of pax8 , indicating a very early role for this gene in placode formation. In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>12538519</pmid><doi>10.1242/dev.00308</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2003-03, Vol.130 (5), p.929-940 |
| issn | 0950-1991 1477-9129 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Amino Acid Sequence Animals Base Sequence Danio rerio DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Ear - embryology Embryonic Structures - embryology Forkhead Transcription Factors foxi1 gene Gene Expression Regulation, Developmental Humans In Situ Hybridization Mandible - embryology Molecular Sequence Data Mutation Neural Crest - cytology Neural Crest - physiology Nuclear Proteins Paired Box Transcription Factors pax8 protein PAX8 Transcription Factor Phenotype placodes Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Zebrafish - anatomy & histology Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - chemistry Zebrafish Proteins - genetics Zebrafish Proteins - metabolism |
| title | Zebrafish foxi1 mediates otic placode formation and jaw development |
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