Amplification of Chirality from Extremely Low to Greater than 99.5 % ee by Asymmetric Autocatalysis

“Single‐handedly”, in every sense of the word, the alkylation product shown catalyzes its own asymmetric formation from the corresponding aldehyde. In this way the miniscule initial enantiomeric excess of about 0.00005 % was amplified to >99.5 % ee after three cycles.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2003-01, Vol.42 (3), p.315-317
Hauptverfasser:	Sato, Itaru, Urabe, Hiroki, Ishiguro, Saori, Shibata, Takanori, Soai, Kenso
Format:	Artikel
Sprache:	eng
Schlagworte:	alkylations asymmetric synthesis autocatalysis chirality zinc
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	“Single‐handedly”, in every sense of the word, the alkylation product shown catalyzes its own asymmetric formation from the corresponding aldehyde. In this way the miniscule initial enantiomeric excess of about 0.00005 % was amplified to >99.5 % ee after three cycles.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200390105