Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection

Integration of retroviral DNA can serve as a paradigm for cellular functions that are affected by the packaging of DNA into chromatin. We have used a novel polymerase chain reaction-based assay to survey DNA and chromatin for the precise distribution of many integration sites. Integration into naked...

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Veröffentlicht in:	Cell 1992-05, Vol.69 (5), p.769-780
Hauptverfasser:	Pryciak, Peter M., Varmus, Harold E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences DNA, Viral - metabolism DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Genic rearrangement. Recombination. Transposable element Leukemia Virus, Murine - metabolism Molecular and cellular biology Molecular genetics Molecular Sequence Data Nucleosomes - metabolism Oligodeoxyribonucleotides - genetics Polymerase Chain Reaction Virus Integration - genetics
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