Antibody response to a viral transcriptional regulator

The E2 transcriptional activator of the human papillomavirus regulates the expression of most viral transcripts. Its binding to specific target DNA sequences involves large conformational changes in the interacting macromolecules. The high stability of the E2:DNA complex prompted us to analyze the r...

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Veröffentlicht in:	FEBS letters 2003-01, Vol.534 (1), p.202-206
Hauptverfasser:	Cerutti, M.Laura, Centeno, Juan M., de Prat-Gay, Gonzalo, Goldbaum, Fernando A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - chemistry AE2 protein Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibody Antigen binding BSA, bovine serum albumin Conformational epitope DNA, Viral - immunology DNA-Binding Proteins E2C, E2 C-terminal DNA-binding and dimerization domain Epitope Mapping Human papillomavirus IP, intraperitoneal administration mAb, monoclonal antibody Mice Oncogene Proteins, Viral - immunology Papillomaviridae Site 35, double-stranded 18 bp oligonucleotide TBS, Tris-buffered saline Transcription factor Transcription Factors - immunology Transcription Factors - metabolism
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