A unique role for IL-23 in promoting cellular immunity
Recent discoveries of interleukin (IL)‐23, its receptor, and its signal‐transduction pathway add to our understanding of cellular immunity. IL‐23 is a heterodimer, comprising IL‐12 p40 and the recently cloned IL‐23‐specific p19 subunit. IL‐23 uses many of the same signal‐transduction components as I...
Gespeichert in:
| Veröffentlicht in: | Journal of leukocyte biology 2003-01, Vol.73 (1), p.49-56 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 56 |
|---|---|
| container_issue | 1 |
| container_start_page | 49 |
| container_title | Journal of leukocyte biology |
| container_volume | 73 |
| creator | Lankford, Carla S. R. Frucht, David M. |
| description | Recent discoveries of interleukin (IL)‐23, its receptor, and its signal‐transduction pathway add to our understanding of cellular immunity. IL‐23 is a heterodimer, comprising IL‐12 p40 and the recently cloned IL‐23‐specific p19 subunit. IL‐23 uses many of the same signal‐transduction components as IL‐12, including IL‐12Rβ1, Janus kinase 2, Tyk2, signal transducer and activator of transcription (Stat)1, Stat3, Stat4, and Stat5. This may explain the similar actions of IL‐12 and IL‐23 in promoting cellular immunity by inducing interferon‐γ production and proliferative responses in target cells. Additionally, both cytokines promote the T helper cell type 1 costimulatory function of antigen‐presenting cells. IL‐23 does differ from IL‐12 in the T cell subsets that it targets. Whereas IL‐12 acts on naïve CD4+ T cells, IL‐23 preferentially acts on memory CD4+ T cells. This review summarizes recent advances regarding IL‐23, providing a functional and mechanistic basis for the unique niche that IL‐23 occupies in cellular immunity. |
| doi_str_mv | 10.1189/jlb.0602326 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72966699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18682037</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4529-655a87c6a518cd0b5a6ed33d0776c4f3944f13ccc12b4913ddae0ec3bd37b1793</originalsourceid><addsrcrecordid>eNqF0DtPwzAUBWALgWgpTOwoA2JBKdd2bCcjVDyKIrHAbDmO07pymmI3ivrvcdVKbDB5-Xzu0UHoGsMU47x4WLlqChwIJfwEjXFB85RyQU_RGESGU5YBjNBFCCsAiAbO0QgTRhjjeIz4Y9Kv7XdvEt85kzSdT-ZlSmhi18nGd223tetFoo1zvVM-sW0b-XZ3ic4a5YK5Or4T9PXy_Dl7S8uP1_nssUx1xkiRcsZULjRXDOe6hoopbmpKaxCC66yhRZY1mGqtMamyAtO6VgaMplVNRYVFQSfo7pAbu8SSYStbG_Zt1Np0fZCCFJzz4n-Ic54ToCLC-wPUvgvBm0ZuvG2V30kMcr-njHvK455R3xxj-6o19a89DhgBHMBgndn9lSXfyyeAbF_19vBlaRfLwXojQ6ucixeIHIZBUIllZD8GsYpR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18682037</pqid></control><display><type>article</type><title>A unique role for IL-23 in promoting cellular immunity</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Lankford, Carla S. R. ; Frucht, David M.</creator><creatorcontrib>Lankford, Carla S. R. ; Frucht, David M.</creatorcontrib><description>Recent discoveries of interleukin (IL)‐23, its receptor, and its signal‐transduction pathway add to our understanding of cellular immunity. IL‐23 is a heterodimer, comprising IL‐12 p40 and the recently cloned IL‐23‐specific p19 subunit. IL‐23 uses many of the same signal‐transduction components as IL‐12, including IL‐12Rβ1, Janus kinase 2, Tyk2, signal transducer and activator of transcription (Stat)1, Stat3, Stat4, and Stat5. This may explain the similar actions of IL‐12 and IL‐23 in promoting cellular immunity by inducing interferon‐γ production and proliferative responses in target cells. Additionally, both cytokines promote the T helper cell type 1 costimulatory function of antigen‐presenting cells. IL‐23 does differ from IL‐12 in the T cell subsets that it targets. Whereas IL‐12 acts on naïve CD4+ T cells, IL‐23 preferentially acts on memory CD4+ T cells. This review summarizes recent advances regarding IL‐23, providing a functional and mechanistic basis for the unique niche that IL‐23 occupies in cellular immunity.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1189/jlb.0602326</identifier><identifier>PMID: 12525561</identifier><language>eng</language><publisher>United States: Society for Leukocyte Biology</publisher><subject>Animals ; CD4-Positive T-Lymphocytes - immunology ; Humans ; IL‐12 ; IL‐12R ; IL‐23R ; Immunity, Cellular ; Interleukin-12 - immunology ; Interleukin-23 ; Interleukin-23 Subunit p19 ; Interleukins - immunology ; Interleukins - physiology ; Mice ; Signal Transduction - immunology ; Stat4</subject><ispartof>Journal of leukocyte biology, 2003-01, Vol.73 (1), p.49-56</ispartof><rights>2003 Society for Leukocyte Biology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4529-655a87c6a518cd0b5a6ed33d0776c4f3944f13ccc12b4913ddae0ec3bd37b1793</citedby><cites>FETCH-LOGICAL-c4529-655a87c6a518cd0b5a6ed33d0776c4f3944f13ccc12b4913ddae0ec3bd37b1793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1189%2Fjlb.0602326$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1189%2Fjlb.0602326$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12525561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lankford, Carla S. R.</creatorcontrib><creatorcontrib>Frucht, David M.</creatorcontrib><title>A unique role for IL-23 in promoting cellular immunity</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>Recent discoveries of interleukin (IL)‐23, its receptor, and its signal‐transduction pathway add to our understanding of cellular immunity. IL‐23 is a heterodimer, comprising IL‐12 p40 and the recently cloned IL‐23‐specific p19 subunit. IL‐23 uses many of the same signal‐transduction components as IL‐12, including IL‐12Rβ1, Janus kinase 2, Tyk2, signal transducer and activator of transcription (Stat)1, Stat3, Stat4, and Stat5. This may explain the similar actions of IL‐12 and IL‐23 in promoting cellular immunity by inducing interferon‐γ production and proliferative responses in target cells. Additionally, both cytokines promote the T helper cell type 1 costimulatory function of antigen‐presenting cells. IL‐23 does differ from IL‐12 in the T cell subsets that it targets. Whereas IL‐12 acts on naïve CD4+ T cells, IL‐23 preferentially acts on memory CD4+ T cells. This review summarizes recent advances regarding IL‐23, providing a functional and mechanistic basis for the unique niche that IL‐23 occupies in cellular immunity.</description><subject>Animals</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Humans</subject><subject>IL‐12</subject><subject>IL‐12R</subject><subject>IL‐23R</subject><subject>Immunity, Cellular</subject><subject>Interleukin-12 - immunology</subject><subject>Interleukin-23</subject><subject>Interleukin-23 Subunit p19</subject><subject>Interleukins - immunology</subject><subject>Interleukins - physiology</subject><subject>Mice</subject><subject>Signal Transduction - immunology</subject><subject>Stat4</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtPwzAUBWALgWgpTOwoA2JBKdd2bCcjVDyKIrHAbDmO07pymmI3ivrvcdVKbDB5-Xzu0UHoGsMU47x4WLlqChwIJfwEjXFB85RyQU_RGESGU5YBjNBFCCsAiAbO0QgTRhjjeIz4Y9Kv7XdvEt85kzSdT-ZlSmhi18nGd223tetFoo1zvVM-sW0b-XZ3ic4a5YK5Or4T9PXy_Dl7S8uP1_nssUx1xkiRcsZULjRXDOe6hoopbmpKaxCC66yhRZY1mGqtMamyAtO6VgaMplVNRYVFQSfo7pAbu8SSYStbG_Zt1Np0fZCCFJzz4n-Ic54ToCLC-wPUvgvBm0ZuvG2V30kMcr-njHvK455R3xxj-6o19a89DhgBHMBgndn9lSXfyyeAbF_19vBlaRfLwXojQ6ucixeIHIZBUIllZD8GsYpR</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Lankford, Carla S. R.</creator><creator>Frucht, David M.</creator><general>Society for Leukocyte Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>A unique role for IL-23 in promoting cellular immunity</title><author>Lankford, Carla S. R. ; Frucht, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4529-655a87c6a518cd0b5a6ed33d0776c4f3944f13ccc12b4913ddae0ec3bd37b1793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Humans</topic><topic>IL‐12</topic><topic>IL‐12R</topic><topic>IL‐23R</topic><topic>Immunity, Cellular</topic><topic>Interleukin-12 - immunology</topic><topic>Interleukin-23</topic><topic>Interleukin-23 Subunit p19</topic><topic>Interleukins - immunology</topic><topic>Interleukins - physiology</topic><topic>Mice</topic><topic>Signal Transduction - immunology</topic><topic>Stat4</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lankford, Carla S. R.</creatorcontrib><creatorcontrib>Frucht, David M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lankford, Carla S. R.</au><au>Frucht, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A unique role for IL-23 in promoting cellular immunity</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>73</volume><issue>1</issue><spage>49</spage><epage>56</epage><pages>49-56</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>Recent discoveries of interleukin (IL)‐23, its receptor, and its signal‐transduction pathway add to our understanding of cellular immunity. IL‐23 is a heterodimer, comprising IL‐12 p40 and the recently cloned IL‐23‐specific p19 subunit. IL‐23 uses many of the same signal‐transduction components as IL‐12, including IL‐12Rβ1, Janus kinase 2, Tyk2, signal transducer and activator of transcription (Stat)1, Stat3, Stat4, and Stat5. This may explain the similar actions of IL‐12 and IL‐23 in promoting cellular immunity by inducing interferon‐γ production and proliferative responses in target cells. Additionally, both cytokines promote the T helper cell type 1 costimulatory function of antigen‐presenting cells. IL‐23 does differ from IL‐12 in the T cell subsets that it targets. Whereas IL‐12 acts on naïve CD4+ T cells, IL‐23 preferentially acts on memory CD4+ T cells. This review summarizes recent advances regarding IL‐23, providing a functional and mechanistic basis for the unique niche that IL‐23 occupies in cellular immunity.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>12525561</pmid><doi>10.1189/jlb.0602326</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0741-5400 |
| ispartof | Journal of leukocyte biology, 2003-01, Vol.73 (1), p.49-56 |
| issn | 0741-5400 1938-3673 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72966699 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals CD4-Positive T-Lymphocytes - immunology Humans IL‐12 IL‐12R IL‐23R Immunity, Cellular Interleukin-12 - immunology Interleukin-23 Interleukin-23 Subunit p19 Interleukins - immunology Interleukins - physiology Mice Signal Transduction - immunology Stat4 |
| title | A unique role for IL-23 in promoting cellular immunity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T18%3A28%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20unique%20role%20for%20IL-23%20in%20promoting%20cellular%20immunity&rft.jtitle=Journal%20of%20leukocyte%20biology&rft.au=Lankford,%20Carla%20S.%20R.&rft.date=2003-01-01&rft.volume=73&rft.issue=1&rft.spage=49&rft.epage=56&rft.pages=49-56&rft.issn=0741-5400&rft.eissn=1938-3673&rft_id=info:doi/10.1189/jlb.0602326&rft_dat=%3Cproquest_cross%3E18682037%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18682037&rft_id=info:pmid/12525561&rfr_iscdi=true |