CIRCUMVENTION OF MULTIDRUG RESISTANCE IN HUMAN CARCINOMA KB CELLS BY POLYETHER ANTIBIOTICS

We examined the effect of various polyether antibiotics on colchicine resistance in multidrug-resistant KB-C4 cells which exhibit about 4, 000-fold resistance to colchicine. As a result, 4 out of 14 polyether antibiotics were found to reverse colchicine resistance. Among them, laidlomycin was the mo...

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Veröffentlicht in:	Journal of antibiotics 1992/04/25, Vol.45(4), pp.556-562
Hauptverfasser:	KAWADA, MANABU, SUMI, SATORU, UMEZAWA, KAZUO, INOUYE, SHIGEHARU, SAWA, TSUTOMU, SETO, HARUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antineoplastic agents Biological and medical sciences Cell Membrane - metabolism Colchicine - pharmacology Drug Resistance - physiology Drug Screening Assays, Antitumor - methods Ethers General aspects Humans Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Tumor Cells, Cultured Vinblastine - metabolism
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