Sex steroids possess distinct stimulus properties in female and male mice
Very few studies have investigated the aversive properties of sex steroids in animals. We studied these properties by testing oestradiol-3-benzoate, testosterone-propionate and progesterone in a conditioned taste aversion set-up, in intact female and male mice. Oestradiol-3-benzoate induced a taste...
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Veröffentlicht in: | Brain research bulletin 1992-02, Vol.28 (2), p.319-321 |
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description | Very few studies have investigated the aversive properties of sex steroids in animals. We studied these properties by testing oestradiol-3-benzoate, testosterone-propionate and progesterone in a conditioned taste aversion set-up, in intact female and male mice. Oestradiol-3-benzoate induced a taste aversion in both female and male mice; however, testosterone-propionate and progesterone had an effect only in females. These results show that sex steroids have intrinsic aversive properties. The different effects of the steroids in males and females cannot simply be explained by nausea induction or novelty. |
doi_str_mv | 10.1016/0361-9230(92)90195-4 |
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We studied these properties by testing oestradiol-3-benzoate, testosterone-propionate and progesterone in a conditioned taste aversion set-up, in intact female and male mice. Oestradiol-3-benzoate induced a taste aversion in both female and male mice; however, testosterone-propionate and progesterone had an effect only in females. These results show that sex steroids have intrinsic aversive properties. The different effects of the steroids in males and females cannot simply be explained by nausea induction or novelty.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conditioned taste aversion</subject><subject>Conditioning (Psychology) - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Female mice</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and behavior</subject><subject>Male</subject><subject>Male mice</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Oestradiol-3-benzoate</subject><subject>Progesterone</subject><subject>Progesterone - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychology</topic><topic>Hormones and behavior</topic><topic>Male</topic><topic>Male mice</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Oestradiol-3-benzoate</topic><topic>Progesterone</topic><topic>Progesterone - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. 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subjects | Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences Conditioned taste aversion Conditioning (Psychology) - drug effects Dose-Response Relationship, Drug Estradiol - pharmacology Female Female mice Fundamental and applied biological sciences. Psychology Hormones and behavior Male Male mice Mice Mice, Inbred ICR Oestradiol-3-benzoate Progesterone Progesterone - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Sex Characteristics Sex steroids Taste Testosterone - pharmacology Testosterone-propionate |
title | Sex steroids possess distinct stimulus properties in female and male mice |
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