Sex steroids possess distinct stimulus properties in female and male mice

Very few studies have investigated the aversive properties of sex steroids in animals. We studied these properties by testing oestradiol-3-benzoate, testosterone-propionate and progesterone in a conditioned taste aversion set-up, in intact female and male mice. Oestradiol-3-benzoate induced a taste...

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Veröffentlicht in:Brain research bulletin 1992-02, Vol.28 (2), p.319-321
Hauptverfasser: Peeters, B.W.M.M., Smets, R.J.M., Broekkamp, C.L.E.
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container_title Brain research bulletin
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creator Peeters, B.W.M.M.
Smets, R.J.M.
Broekkamp, C.L.E.
description Very few studies have investigated the aversive properties of sex steroids in animals. We studied these properties by testing oestradiol-3-benzoate, testosterone-propionate and progesterone in a conditioned taste aversion set-up, in intact female and male mice. Oestradiol-3-benzoate induced a taste aversion in both female and male mice; however, testosterone-propionate and progesterone had an effect only in females. These results show that sex steroids have intrinsic aversive properties. The different effects of the steroids in males and females cannot simply be explained by nausea induction or novelty.
doi_str_mv 10.1016/0361-9230(92)90195-4
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source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Analysis of Variance
Animals
Behavioral psychophysiology
Biological and medical sciences
Conditioned taste aversion
Conditioning (Psychology) - drug effects
Dose-Response Relationship, Drug
Estradiol - pharmacology
Female
Female mice
Fundamental and applied biological sciences. Psychology
Hormones and behavior
Male
Male mice
Mice
Mice, Inbred ICR
Oestradiol-3-benzoate
Progesterone
Progesterone - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Sex Characteristics
Sex steroids
Taste
Testosterone - pharmacology
Testosterone-propionate
title Sex steroids possess distinct stimulus properties in female and male mice
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