Complete loss of HLA class I antigen expression on melanoma cells: A result of successive mutational events

Alterations in the surface expression of HLA class I molecules have been described as a strategy of tumors to evade recognition by cytotoxic T cells. We detected complete loss of HLA class I antigen presentation for 2 tumor cell lines from 1 melanoma patient, the first originated from a regional lym...

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Veröffentlicht in:	International journal of cancer 2003-03, Vol.103 (6), p.759-767
Hauptverfasser:	Paschen, Annette, Méndez, Rosa María, Jimenez, Pilar, Sucker, Antje, Ruiz‐Cabello, Francisco, Song, Mingxia, Garrido, Federico, Schadendorf, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigen Presentation - drug effects beta 2-Microglobulin - genetics beta 2-Microglobulin - metabolism Biological and medical sciences Blotting, Southern chromosomal aberration Chromosome Aberrations Chromosomes, Human, Pair 15 - genetics Dermatology DNA, Neoplasm - analysis Female Gene Deletion HeLa Cells Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology HLA loss Humans immune escape In Situ Hybridization, Fluorescence Loss of Heterozygosity Lymphocyte Activation Medical sciences Melanoma - genetics Melanoma - immunology Microsatellite Repeats mutation Pleural Effusion - genetics Pleural Effusion - immunology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Skin Neoplasms - genetics Skin Neoplasms - immunology T-Lymphocytes, Cytotoxic - immunology Transfection Tumor Cells, Cultured Tumors of the skin and soft tissue. Premalignant lesions β2‐microglobulin
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