Egg hypersensitivity and adverse reactions to measles, mumps, and rubella vaccine
We evaluated the safety of the measles-mumps-rubella (MMR) combination vaccine in 140 children with egg hypersensitivity. All children, regardiess of vaccine skin test results or severity of egg hypersensitivity, were safely immunized with the MMR vaccine. Systemic reactions to MMR vaccine in two no...
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| Veröffentlicht in: | The Journal of pediatrics 1992-06, Vol.120 (6), p.878-881 |
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| container_issue | 6 |
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| container_title | The Journal of pediatrics |
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| creator | Fasano, Mary Beth Wood, Robert A. Cooke, Sara K. Sampson, Hugh A. |
| description | We evaluated the safety of the measles-mumps-rubella (MMR) combination vaccine in 140 children with egg hypersensitivity. All children, regardiess of vaccine skin test results or severity of egg hypersensitivity, were safely immunized with the MMR vaccine. Systemic reactions to MMR vaccine in two nonallergic children were documented, indicating that reactions unrelated to egg protein can occur. With the use of a competitive enzyme-linked immunosorbent assay, the standard MMR injection was found to contain approximately 37 pg of ovalbumin-like material. This study provides 95% confidence that at least 97.5% of egg-allergic children will tolerate MMR vaccine without significant difficulty. Skin testing was not found to be helpful in predicting an adverse reaction. We recommend that the American Academy of Pediatrics consider revising its current policy regarding skin test response to MMR vaccine and administration of MMR vaccine to egg-allergic children. |
| doi_str_mv | 10.1016/S0022-3476(05)81953-5 |
| format | Article |
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All children, regardiess of vaccine skin test results or severity of egg hypersensitivity, were safely immunized with the MMR vaccine. Systemic reactions to MMR vaccine in two nonallergic children were documented, indicating that reactions unrelated to egg protein can occur. With the use of a competitive enzyme-linked immunosorbent assay, the standard MMR injection was found to contain approximately 37 pg of ovalbumin-like material. This study provides 95% confidence that at least 97.5% of egg-allergic children will tolerate MMR vaccine without significant difficulty. Skin testing was not found to be helpful in predicting an adverse reaction. 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All children, regardiess of vaccine skin test results or severity of egg hypersensitivity, were safely immunized with the MMR vaccine. Systemic reactions to MMR vaccine in two nonallergic children were documented, indicating that reactions unrelated to egg protein can occur. With the use of a competitive enzyme-linked immunosorbent assay, the standard MMR injection was found to contain approximately 37 pg of ovalbumin-like material. This study provides 95% confidence that at least 97.5% of egg-allergic children will tolerate MMR vaccine without significant difficulty. Skin testing was not found to be helpful in predicting an adverse reaction. We recommend that the American Academy of Pediatrics consider revising its current policy regarding skin test response to MMR vaccine and administration of MMR vaccine to egg-allergic children.</description><subject>Allergic diseases</subject><subject>Anaphylaxis - epidemiology</subject><subject>Anaphylaxis - etiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Digestive allergic diseases</subject><subject>Drug Combinations</subject><subject>Drug Evaluation</subject><subject>Eggs - adverse effects</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Food Hypersensitivity - immunology</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Measles Vaccine - adverse effects</subject><subject>Measles-Mumps-Rubella Vaccine</subject><subject>Medical sciences</subject><subject>Mumps Vaccine - adverse effects</subject><subject>Predictive Value of Tests</subject><subject>Rubella Vaccine - adverse effects</subject><subject>Skin Tests</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMouj5-gtCDiILVpEna9CSyrA8QRNRzSKbTNdLHmrQL--9t3WU9ehqY-eb1EXLK6DWjLL15ozRJYi6y9ILKS8VyyWO5QyaM5lmcKs53yWSLHJDDEL4opbmgdJ_sM5lzLtIJeZ3N59HnaoE-YBNc55auW0WmKSJTLMdk5NFA59omRF0b1WhCheEqqvt6MYQR9L3FqjLR0gC4Bo_JXmmqgCebeEQ-7mfv08f4-eXhaXr3HINgqotBMgbAUKC1mSpKJROrgDPLuDUJgACVlqlILBiVibJEYQuZMzN8pFBByY_I-XruwrffPYZO1y7AeEmDbR90luQpzZJsAOUaBN-G4LHUC-9q41eaUT2q1L8q9ehJU6l_VWo59J1uFvS2xuKva-1uqJ9t6iaAqUpvGnBhiwnJVa7yAbtdYzjIWDr0OoDDBrBwHqHTRev-OeQH1zWRIQ</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>Fasano, Mary Beth</creator><creator>Wood, Robert A.</creator><creator>Cooke, Sara K.</creator><creator>Sampson, Hugh A.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920601</creationdate><title>Egg hypersensitivity and adverse reactions to measles, mumps, and rubella vaccine</title><author>Fasano, Mary Beth ; Wood, Robert A. ; Cooke, Sara K. ; Sampson, Hugh A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-c511cc1e4ebb78df852b8c31b13ba2cc4c86f642bca874ffe4bd591a0228e8cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Allergic diseases</topic><topic>Anaphylaxis - epidemiology</topic><topic>Anaphylaxis - etiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Digestive allergic diseases</topic><topic>Drug Combinations</topic><topic>Drug Evaluation</topic><topic>Eggs - adverse effects</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Food Hypersensitivity - immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Measles Vaccine - adverse effects</topic><topic>Measles-Mumps-Rubella Vaccine</topic><topic>Medical sciences</topic><topic>Mumps Vaccine - adverse effects</topic><topic>Predictive Value of Tests</topic><topic>Rubella Vaccine - adverse effects</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fasano, Mary Beth</creatorcontrib><creatorcontrib>Wood, Robert A.</creatorcontrib><creatorcontrib>Cooke, Sara K.</creatorcontrib><creatorcontrib>Sampson, Hugh A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fasano, Mary Beth</au><au>Wood, Robert A.</au><au>Cooke, Sara K.</au><au>Sampson, Hugh A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Egg hypersensitivity and adverse reactions to measles, mumps, and rubella vaccine</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>120</volume><issue>6</issue><spage>878</spage><epage>881</epage><pages>878-881</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>We evaluated the safety of the measles-mumps-rubella (MMR) combination vaccine in 140 children with egg hypersensitivity. All children, regardiess of vaccine skin test results or severity of egg hypersensitivity, were safely immunized with the MMR vaccine. Systemic reactions to MMR vaccine in two nonallergic children were documented, indicating that reactions unrelated to egg protein can occur. With the use of a competitive enzyme-linked immunosorbent assay, the standard MMR injection was found to contain approximately 37 pg of ovalbumin-like material. This study provides 95% confidence that at least 97.5% of egg-allergic children will tolerate MMR vaccine without significant difficulty. Skin testing was not found to be helpful in predicting an adverse reaction. We recommend that the American Academy of Pediatrics consider revising its current policy regarding skin test response to MMR vaccine and administration of MMR vaccine to egg-allergic children.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>1593346</pmid><doi>10.1016/S0022-3476(05)81953-5</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1992-06, Vol.120 (6), p.878-881 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergic diseases Anaphylaxis - epidemiology Anaphylaxis - etiology Biological and medical sciences Child Digestive allergic diseases Drug Combinations Drug Evaluation Eggs - adverse effects Enzyme-Linked Immunosorbent Assay Female Food Hypersensitivity - immunology Humans Immunopathology Male Measles Vaccine - adverse effects Measles-Mumps-Rubella Vaccine Medical sciences Mumps Vaccine - adverse effects Predictive Value of Tests Rubella Vaccine - adverse effects Skin Tests |
| title | Egg hypersensitivity and adverse reactions to measles, mumps, and rubella vaccine |
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