Effects of three methods of selection for litter size in mice on pre-implantation embryonic development
Characteristics of preimplantation embryonic development to Day 3.5 of gestation were evaluated in lines of mice after 21 generations of selection for litter size or components of litter size. Selection criteria were direct selection for number born (LS), selection on an index of ovulation rate and...
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| Veröffentlicht in: | Biology of reproduction 1992-05, Vol.46 (5), p.958-963 |
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| creator | al-Shorepy, S A Clutter, A C Blair, R M Nielsen, M K |
| description | Characteristics of preimplantation embryonic development to Day 3.5 of gestation were evaluated in lines of mice after 21
generations of selection for litter size or components of litter size. Selection criteria were direct selection for number
born (LS), selection on an index of ovulation rate and the proportion of ova shed that resulted in fully formed pups (IX),
selection for number born in unilaterally ovariectomized females as an indication of uterine capacity (UT), and an unselected
control (LC). Comparison of the average distributions of embryonic stage of development on the left side of the uterus showed
that selection (average effect of LS, IX, and UT vs. LC) tended to advance (p = 0.07) the average stage of embryonic development
at Day 3.5 and shift the distribution (p = 0.10) by increasing the frequency of expanded blastocysts and decreasing the frequency
of pre-morula embryos. A similar shift in the distribution on the right side of the uterus was not statistically significant.
Selection decreased (p = 0.06) variability in developmental stage among embryos within the right uterine horn. These selection
criteria evaluated in the mouse appear to have changed the frequencies of genes that affect some determinants of average stage
of embryonic development and uniformity of development within a uterine horn at Day 3.5 of gestation. |
| doi_str_mv | 10.1095/biolreprod46.5.958 |
| format | Article |
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generations of selection for litter size or components of litter size. Selection criteria were direct selection for number
born (LS), selection on an index of ovulation rate and the proportion of ova shed that resulted in fully formed pups (IX),
selection for number born in unilaterally ovariectomized females as an indication of uterine capacity (UT), and an unselected
control (LC). Comparison of the average distributions of embryonic stage of development on the left side of the uterus showed
that selection (average effect of LS, IX, and UT vs. LC) tended to advance (p = 0.07) the average stage of embryonic development
at Day 3.5 and shift the distribution (p = 0.10) by increasing the frequency of expanded blastocysts and decreasing the frequency
of pre-morula embryos. A similar shift in the distribution on the right side of the uterus was not statistically significant.
Selection decreased (p = 0.06) variability in developmental stage among embryos within the right uterine horn. These selection
criteria evaluated in the mouse appear to have changed the frequencies of genes that affect some determinants of average stage
of embryonic development and uniformity of development within a uterine horn at Day 3.5 of gestation.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod46.5.958</identifier><identifier>PMID: 1591352</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Blastocyst - cytology ; Early stages. Segmentation. Gastrulation. Neurulation ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Litter Size - genetics ; Mice ; Ovulation ; Pregnancy</subject><ispartof>Biology of reproduction, 1992-05, Vol.46 (5), p.958-963</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5250154$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1591352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>al-Shorepy, S A</creatorcontrib><creatorcontrib>Clutter, A C</creatorcontrib><creatorcontrib>Blair, R M</creatorcontrib><creatorcontrib>Nielsen, M K</creatorcontrib><title>Effects of three methods of selection for litter size in mice on pre-implantation embryonic development</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>Characteristics of preimplantation embryonic development to Day 3.5 of gestation were evaluated in lines of mice after 21
generations of selection for litter size or components of litter size. Selection criteria were direct selection for number
born (LS), selection on an index of ovulation rate and the proportion of ova shed that resulted in fully formed pups (IX),
selection for number born in unilaterally ovariectomized females as an indication of uterine capacity (UT), and an unselected
control (LC). Comparison of the average distributions of embryonic stage of development on the left side of the uterus showed
that selection (average effect of LS, IX, and UT vs. LC) tended to advance (p = 0.07) the average stage of embryonic development
at Day 3.5 and shift the distribution (p = 0.10) by increasing the frequency of expanded blastocysts and decreasing the frequency
of pre-morula embryos. A similar shift in the distribution on the right side of the uterus was not statistically significant.
Selection decreased (p = 0.06) variability in developmental stage among embryos within the right uterine horn. These selection
criteria evaluated in the mouse appear to have changed the frequencies of genes that affect some determinants of average stage
of embryonic development and uniformity of development within a uterine horn at Day 3.5 of gestation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blastocyst - cytology</subject><subject>Early stages. Segmentation. Gastrulation. Neurulation</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Litter Size - genetics</subject><subject>Mice</subject><subject>Ovulation</subject><subject>Pregnancy</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtLxDAUhYMoOo7-AUHIQt11zKNpm6XI-ADBja5L2t7YSNLUJOOgv96gg6vLvefjcDgXoTNKVpRIcd0ZbwPMwQ9ltRIrKZo9tKCCyaJmVbOPFoSQquC84kfoOMZ3QmjJGT9Eh1RIygVboLe11tCniL3GaQwA2EEa_fB7iGCzZvyEtQ_YmpQg4Gi-AZsJO9MDztIcoDButmpK6pcF14UvP5keD_AJ1s8OpnSCDrSyEU53c4le79Yvtw_F0_P94-3NUzHShqRCCc45k1XT5JyK0po2neKg85QdEJ23XkilWU_rmlPacNERVg-S61LWpeJLdPXnm1v52EBMrTOxB5vjgd_EtmZSSFmSDJ7vwE3nYGjnYJwKX-2umaxf7HQVe2V1UFNv4j8mmCBUlBm7_MNG8zZuTYA2OmVtNuXtdrstq1a0-S_8BxyegeY</recordid><startdate>199205</startdate><enddate>199205</enddate><creator>al-Shorepy, S A</creator><creator>Clutter, A C</creator><creator>Blair, R M</creator><creator>Nielsen, M K</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199205</creationdate><title>Effects of three methods of selection for litter size in mice on pre-implantation embryonic development</title><author>al-Shorepy, S A ; Clutter, A C ; Blair, R M ; Nielsen, M K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h180t-a533329688323a11718ba3ef7189be0f8bac59af2c177311835b027d93f4974a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blastocyst - cytology</topic><topic>Early stages. Segmentation. Gastrulation. Neurulation</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Litter Size - genetics</topic><topic>Mice</topic><topic>Ovulation</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>al-Shorepy, S A</creatorcontrib><creatorcontrib>Clutter, A C</creatorcontrib><creatorcontrib>Blair, R M</creatorcontrib><creatorcontrib>Nielsen, M K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>al-Shorepy, S A</au><au>Clutter, A C</au><au>Blair, R M</au><au>Nielsen, M K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of three methods of selection for litter size in mice on pre-implantation embryonic development</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1992-05</date><risdate>1992</risdate><volume>46</volume><issue>5</issue><spage>958</spage><epage>963</epage><pages>958-963</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>Characteristics of preimplantation embryonic development to Day 3.5 of gestation were evaluated in lines of mice after 21
generations of selection for litter size or components of litter size. Selection criteria were direct selection for number
born (LS), selection on an index of ovulation rate and the proportion of ova shed that resulted in fully formed pups (IX),
selection for number born in unilaterally ovariectomized females as an indication of uterine capacity (UT), and an unselected
control (LC). Comparison of the average distributions of embryonic stage of development on the left side of the uterus showed
that selection (average effect of LS, IX, and UT vs. LC) tended to advance (p = 0.07) the average stage of embryonic development
at Day 3.5 and shift the distribution (p = 0.10) by increasing the frequency of expanded blastocysts and decreasing the frequency
of pre-morula embryos. A similar shift in the distribution on the right side of the uterus was not statistically significant.
Selection decreased (p = 0.06) variability in developmental stage among embryos within the right uterine horn. These selection
criteria evaluated in the mouse appear to have changed the frequencies of genes that affect some determinants of average stage
of embryonic development and uniformity of development within a uterine horn at Day 3.5 of gestation.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>1591352</pmid><doi>10.1095/biolreprod46.5.958</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biology of reproduction, 1992-05, Vol.46 (5), p.958-963 |
| issn | 0006-3363 1529-7268 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Blastocyst - cytology Early stages. Segmentation. Gastrulation. Neurulation Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - genetics Female Fundamental and applied biological sciences. Psychology Gestational Age Litter Size - genetics Mice Ovulation Pregnancy |
| title | Effects of three methods of selection for litter size in mice on pre-implantation embryonic development |
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