Differential rearing conditions in rats: Effects on neurochemistry in neocortical areas and cognitive behaviors
Previous studies have shown that environmental factors can influence several aspects of the central nervous system that are associated with behavioral changes. In the present study, an attempt was made to investigate how cholinergic and glutamergic transmission systems in neocortical areas might res...
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| Veröffentlicht in: | Brain research bulletin 1992-03, Vol.28 (3), p.427-434 |
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| creator | Myhrer, Trond Utsikt, Laila Fjelland, Jorunn Iversen, Evy Grini Fonnum, Frode |
| description | Previous studies have shown that environmental factors can influence several aspects of the central nervous system that are associated with behavioral changes. In the present study, an attempt was made to investigate how cholinergic and glutamergic transmission systems in neocortical areas might respond to differential rearing conditions and how potential neurochemical changes might be accompanied by alterations in behavior. The results show that only glutamergic levels in the lateral entorhinal cortex (LEG) responded to differential environmental stimulation. The levels of glutamergic activity in LEG correlated significantly with learning and retention of a visual discrimination task and total time exploring objects in a novelty test. A comparatively complex pattern of neurochemical relations was seen in terms of differences across brain structures and hemispheres for both glutamergic and cholinergic activity. The results are interpreted as supporting the glutamergic hypothesis of Alzheimer's disease. |
| doi_str_mv | 10.1016/0361-9230(92)90043-W |
| format | Article |
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In the present study, an attempt was made to investigate how cholinergic and glutamergic transmission systems in neocortical areas might respond to differential rearing conditions and how potential neurochemical changes might be accompanied by alterations in behavior. The results show that only glutamergic levels in the lateral entorhinal cortex (LEG) responded to differential environmental stimulation. The levels of glutamergic activity in LEG correlated significantly with learning and retention of a visual discrimination task and total time exploring objects in a novelty test. A comparatively complex pattern of neurochemical relations was seen in terms of differences across brain structures and hemispheres for both glutamergic and cholinergic activity. 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The results are interpreted as supporting the glutamergic hypothesis of Alzheimer's disease.</description><subject>Acetylcholine - metabolism</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Body Weight - physiology</subject><subject>Brain Chemistry - physiology</subject><subject>Cerebral Cortex - growth & development</subject><subject>Cerebral Cortex - metabolism</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Cognition - physiology</subject><subject>Differential rearing</subject><subject>Discrimination Learning - physiology</subject><subject>Environment</subject><subject>Exploratory Behavior - physiology</subject><subject>Glutamates - metabolism</subject><subject>Glutamates - physiology</subject><subject>Grooming - physiology</subject><subject>Male</subject><subject>Mnemonic processes</subject><subject>Neocortex</subject><subject>Neurotransmitters</subject><subject>Parasympathetic Nervous System - growth & development</subject><subject>Parasympathetic Nervous System - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reaction to novelty</subject><subject>Temporal Lobe - physiology</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKBDEQRYMoOj7-QCEr0UVrHt1Jx4UgOj5gwI3iMqSTao3MJJr0DPj3ZhzRnUKoLOrUreJehPYpOaGEilPCBa0U4-RIsWNFSM2rpzU0oq3kFZO1XEejH2QLbef8SggRbSM20SZtVHlqhOKV73tIEAZvpjiBST48YxuD84OPIWMfcDJDPsPjwtkh4xhwgHmK9gVmPg_pY4kEiDamwdsiYopKxia4IvMciswCcAcvZuFjyrtoozfTDHvf_w56vB4_XN5Wk_ubu8uLSWV52w6VJK5XXEgwihvOaqFaaWvXEdk1rZLWOEZpqYYAUKhVJ5xggllWEGJlw3fQ4Ur3LcX3OeRBl2MtTKemnDrPWjLVtKRW_4JUMN6Ipi5gvQJtijkn6PVb8jOTPjQlehmIXrqtl26Xor8C0U9l7OBbf97NwP0OrRIo_fNVH4obCw9JZ-shWHA-Fb-1i_7vBZ-6hpxO</recordid><startdate>19920301</startdate><enddate>19920301</enddate><creator>Myhrer, Trond</creator><creator>Utsikt, Laila</creator><creator>Fjelland, Jorunn</creator><creator>Iversen, Evy Grini</creator><creator>Fonnum, Frode</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920301</creationdate><title>Differential rearing conditions in rats: Effects on neurochemistry in neocortical areas and cognitive behaviors</title><author>Myhrer, Trond ; Utsikt, Laila ; Fjelland, Jorunn ; Iversen, Evy Grini ; Fonnum, Frode</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-70df9367ea93a3246987c4db07b5897cad211cada0ee1e49b6d6262c2db00c753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acetylcholine - metabolism</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Body Weight - physiology</topic><topic>Brain Chemistry - physiology</topic><topic>Cerebral Cortex - growth & development</topic><topic>Cerebral Cortex - metabolism</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Cognition - physiology</topic><topic>Differential rearing</topic><topic>Discrimination Learning - physiology</topic><topic>Environment</topic><topic>Exploratory Behavior - physiology</topic><topic>Glutamates - metabolism</topic><topic>Glutamates - physiology</topic><topic>Grooming - physiology</topic><topic>Male</topic><topic>Mnemonic processes</topic><topic>Neocortex</topic><topic>Neurotransmitters</topic><topic>Parasympathetic Nervous System - growth & development</topic><topic>Parasympathetic Nervous System - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reaction to novelty</topic><topic>Temporal Lobe - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Myhrer, Trond</creatorcontrib><creatorcontrib>Utsikt, Laila</creatorcontrib><creatorcontrib>Fjelland, Jorunn</creatorcontrib><creatorcontrib>Iversen, Evy Grini</creatorcontrib><creatorcontrib>Fonnum, Frode</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Myhrer, Trond</au><au>Utsikt, Laila</au><au>Fjelland, Jorunn</au><au>Iversen, Evy Grini</au><au>Fonnum, Frode</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential rearing conditions in rats: Effects on neurochemistry in neocortical areas and cognitive behaviors</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>28</volume><issue>3</issue><spage>427</spage><epage>434</epage><pages>427-434</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>Previous studies have shown that environmental factors can influence several aspects of the central nervous system that are associated with behavioral changes. 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| ispartof | Brain research bulletin, 1992-03, Vol.28 (3), p.427-434 |
| issn | 0361-9230 1873-2747 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetylcholine - metabolism Alzheimer's disease Animals Behavior, Animal - physiology Body Weight - physiology Brain Chemistry - physiology Cerebral Cortex - growth & development Cerebral Cortex - metabolism Choline O-Acetyltransferase - metabolism Cognition - physiology Differential rearing Discrimination Learning - physiology Environment Exploratory Behavior - physiology Glutamates - metabolism Glutamates - physiology Grooming - physiology Male Mnemonic processes Neocortex Neurotransmitters Parasympathetic Nervous System - growth & development Parasympathetic Nervous System - physiology Rats Rats, Inbred Strains Reaction to novelty Temporal Lobe - physiology |
| title | Differential rearing conditions in rats: Effects on neurochemistry in neocortical areas and cognitive behaviors |
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