Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: A preclinical model

Cytotoxic drug treatment of neuroblastoma often leads to the development of drug resistance and may be associated with increased malignancy. To study the effects of long‐term cytotoxic treatment on malignant properties of tumor cells, we established 2 neuroblastoma cell sublines resistant to vincris...

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Veröffentlicht in:	International journal of cancer 2003-03, Vol.104 (1), p.36-43
Hauptverfasser:	Kotchetkov, Rouslan, Cinatl, Jaroslav, Blaheta, Roman, Vogel, Jens‐Uwe, Karaskova, Jana, Squire, Jeremy, Hernáiz Driever, Pablo, Klingebiel, Thomas, Cinatl, Jindrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Animals Antineoplastic agents ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biological and medical sciences Cell Division Cisplatin - pharmacology Clone Cells - pathology Disease Progression Doxorubicin - pharmacology drug resistance Drug Resistance, Neoplasm - genetics Female GD2 Gene Expression Regulation, Neoplastic General aspects Genes, myc Humans In Situ Hybridization, Fluorescence karyotype Karyotyping mdr‐1 Medical sciences Mice Mice, Nude NCAM Neoplasm Invasiveness Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Transplantation Neural Cell Adhesion Molecules - biosynthesis Neural Cell Adhesion Molecules - genetics neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor Stem Cell Assay Vincristine - pharmacology
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