Immunohistochemical study of epidermal growth factor and transforming growth factor-β in the penetrating type of early gastric cancer
We report that the penetrating type of early gastric cancer (PEN) is a specific type of early gastric cancer and that the poorly differentiated PEN type could be considered an initial lesion of linitis plastica-type cancer. We performed an immunohistochemical study to clarify the role of growth fact...
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| Veröffentlicht in: | Human pathology 1992-06, Vol.23 (6), p.681-685 |
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| container_title | Human pathology |
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| creator | Hirayama, Daisuke Fujimori, Takahiro Satonaka, Kazuhiro Nakamura, Tetsuya Kitazawa, Souhei Horio, Mitsuzou Maeda, Sakan Nagasako, Kou |
| description | We report that the penetrating type of early gastric cancer (PEN) is a specific type of early gastric cancer and that the poorly differentiated PEN type could be considered an initial lesion of linitis plastica-type cancer. We performed an immunohistochemical study to clarify the role of growth factors (epidermal growth factor [EGF] and transforming growth factor-β [TGF-β]) in the PEN type of early gastric cancer. The results indicated that the PEN type of early gastric cancer has a high growth capacity. Moreover, it was suggested that EGF was involved in its specific infiltrative growth and that both EGF and TGF-β were involved in its specific scirrhous growth. From these findings, it was assumed that the immunohistochemical staining of EGF and TGF-β in endoscopic biopsy specimens was useful for the diagnosis of the PEN type of gastric cancer and also for the diagnosis of the initial lesion of linitis plastica-type gastric cancer. |
| doi_str_mv | 10.1016/0046-8177(92)90325-W |
| format | Article |
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We performed an immunohistochemical study to clarify the role of growth factors (epidermal growth factor [EGF] and transforming growth factor-β [TGF-β]) in the PEN type of early gastric cancer. The results indicated that the PEN type of early gastric cancer has a high growth capacity. Moreover, it was suggested that EGF was involved in its specific infiltrative growth and that both EGF and TGF-β were involved in its specific scirrhous growth. 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We performed an immunohistochemical study to clarify the role of growth factors (epidermal growth factor [EGF] and transforming growth factor-β [TGF-β]) in the PEN type of early gastric cancer. The results indicated that the PEN type of early gastric cancer has a high growth capacity. Moreover, it was suggested that EGF was involved in its specific infiltrative growth and that both EGF and TGF-β were involved in its specific scirrhous growth. From these findings, it was assumed that the immunohistochemical staining of EGF and TGF-β in endoscopic biopsy specimens was useful for the diagnosis of the PEN type of gastric cancer and also for the diagnosis of the initial lesion of linitis plastica-type gastric cancer.</description><subject>Epidermal Growth Factor - analysis</subject><subject>epidermal-growth factor</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>immunohistochemistry</subject><subject>Neoplasm Invasiveness</subject><subject>penetrating type of early gastric cancer</subject><subject>Stomach Neoplasms - chemistry</subject><subject>Stomach Neoplasms - pathology</subject><subject>Transforming Growth Factor beta - analysis</subject><subject>transforming growth factor-β</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtuFDEQhi0ECkPgBiB5hWDR4Ed73N4goYhHpEhsQFlanuryjFF3u7HdQXMBDsRBcqZ4MhFRNqxK8v_Vb9VHyEvO3nHG1-8Za9dNx7V-Y8Rbw6RQzeUjsuJKiqaTRjwmq3_IU_Is55-Mca5adUJOuDKiIivy53wclynuQi4RdjgGcAPNZen3NHqKc-gxjfVpm-LvsqPeQYmJuqmnJbkp-5jGMG0fxs31XxomWnZIZ5ywguXAlP2Mt6UuDXu6dbmkABTcBJiekyfeDRlf3M1T8uPzp-9nX5uLb1_Ozz5eNCCVLg0orXmHQinPOzBgvOpUB6IFaXDTM47Y6t7XCdCid3JjzLqTG3ActBZSnpLXx945xV8L5mLHkAGHwU0Yl2y1MGotua5gewQhxZwTejunMLq0t5zZg357cGsPbq0R9la_vaxrr-76l82I_f3S0XfNPxxzrEdeBUw2Q8BqoA8Jodg-hv9_cANMCpji</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>Hirayama, Daisuke</creator><creator>Fujimori, Takahiro</creator><creator>Satonaka, Kazuhiro</creator><creator>Nakamura, Tetsuya</creator><creator>Kitazawa, Souhei</creator><creator>Horio, Mitsuzou</creator><creator>Maeda, Sakan</creator><creator>Nagasako, Kou</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920601</creationdate><title>Immunohistochemical study of epidermal growth factor and transforming growth factor-β in the penetrating type of early gastric cancer</title><author>Hirayama, Daisuke ; Fujimori, Takahiro ; Satonaka, Kazuhiro ; Nakamura, Tetsuya ; Kitazawa, Souhei ; Horio, Mitsuzou ; Maeda, Sakan ; Nagasako, Kou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c57718e255f18c9c9f5858c24c39ebd01ee47df01ecc4efa3b99683bca1c77233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Epidermal Growth Factor - analysis</topic><topic>epidermal-growth factor</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>immunohistochemistry</topic><topic>Neoplasm Invasiveness</topic><topic>penetrating type of early gastric cancer</topic><topic>Stomach Neoplasms - chemistry</topic><topic>Stomach Neoplasms - pathology</topic><topic>Transforming Growth Factor beta - analysis</topic><topic>transforming growth factor-β</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirayama, Daisuke</creatorcontrib><creatorcontrib>Fujimori, Takahiro</creatorcontrib><creatorcontrib>Satonaka, Kazuhiro</creatorcontrib><creatorcontrib>Nakamura, Tetsuya</creatorcontrib><creatorcontrib>Kitazawa, Souhei</creatorcontrib><creatorcontrib>Horio, Mitsuzou</creatorcontrib><creatorcontrib>Maeda, Sakan</creatorcontrib><creatorcontrib>Nagasako, Kou</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirayama, Daisuke</au><au>Fujimori, Takahiro</au><au>Satonaka, Kazuhiro</au><au>Nakamura, Tetsuya</au><au>Kitazawa, Souhei</au><au>Horio, Mitsuzou</au><au>Maeda, Sakan</au><au>Nagasako, Kou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical study of epidermal growth factor and transforming growth factor-β in the penetrating type of early gastric cancer</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>23</volume><issue>6</issue><spage>681</spage><epage>685</epage><pages>681-685</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><abstract>We report that the penetrating type of early gastric cancer (PEN) is a specific type of early gastric cancer and that the poorly differentiated PEN type could be considered an initial lesion of linitis plastica-type cancer. We performed an immunohistochemical study to clarify the role of growth factors (epidermal growth factor [EGF] and transforming growth factor-β [TGF-β]) in the PEN type of early gastric cancer. The results indicated that the PEN type of early gastric cancer has a high growth capacity. Moreover, it was suggested that EGF was involved in its specific infiltrative growth and that both EGF and TGF-β were involved in its specific scirrhous growth. From these findings, it was assumed that the immunohistochemical staining of EGF and TGF-β in endoscopic biopsy specimens was useful for the diagnosis of the PEN type of gastric cancer and also for the diagnosis of the initial lesion of linitis plastica-type gastric cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1592392</pmid><doi>10.1016/0046-8177(92)90325-W</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0046-8177 |
| ispartof | Human pathology, 1992-06, Vol.23 (6), p.681-685 |
| issn | 0046-8177 1532-8392 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72956317 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Epidermal Growth Factor - analysis epidermal-growth factor Humans Immunoenzyme Techniques immunohistochemistry Neoplasm Invasiveness penetrating type of early gastric cancer Stomach Neoplasms - chemistry Stomach Neoplasms - pathology Transforming Growth Factor beta - analysis transforming growth factor-β |
| title | Immunohistochemical study of epidermal growth factor and transforming growth factor-β in the penetrating type of early gastric cancer |
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