DNA Microarray Profiling to Identify Angiotensin-Responsive Genes in Vascular Smooth Muscle Cells: Potential Mediators of Vascular Disease

ABSTRACT—Angiotensin II (Ang II) induces changes in vessel structure by its capacity to activate genes that are coupled to signaling pathways such as extracellular signal–regulated kinase (ERK), p38, and phosphatidylinositol 3-kinase (PI3K). Using a DNA microarray containing 5088 genes and expressed...

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Veröffentlicht in:	Circulation research 2003-01, Vol.92 (1), p.111-118
Hauptverfasser:	Campos, Alexandre H, Zhao, Ying, Pollman, Matthew J, Gibbons, Gary H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensins - pharmacology Animals Annexin A2 - genetics Annexin A2 - metabolism Biological and medical sciences Blood vessels and receptors Cell Division - drug effects Cells, Cultured Cluster Analysis Enzyme Inhibitors - pharmacology Expressed Sequence Tags Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gene Expression Profiling Male Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Oligonucleotide Array Sequence Analysis Osteopontin Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Sialoglycoproteins - genetics Sialoglycoproteins - metabolism Signal Transduction - drug effects Up-Regulation - drug effects Vascular Diseases - genetics Vascular Diseases - metabolism Vertebrates: cardiovascular system
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