Molecular modeling and crystallographic studies of 4-amino-N-phenylbenzamide anticonvulsants

The molecular structures of five different MES-active N-phenylbenzamides were determined by X-ray diffraction methods, and the conformations of a series of active and inactive benzamides were analyzed by molecular mechanics calculations. The most active compounds adopt a similar, consistent conforma...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-05, Vol.35 (10), p.1806-1812
Hauptverfasser:	Duke, Norma E. C, Codding, Penelope W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic, non-condensed and condensed benzenic, and alicyclic compounds Anticonvulsants - chemistry Anticonvulsants - pharmacology Benzamides - chemistry Benzamides - pharmacology Condensed matter: structure, mechanical and thermal properties Exact sciences and technology Models, Molecular Organic compounds Physics Structure of solids and liquids crystallography Structure of specific crystalline solids Structure-Activity Relationship X-Ray Diffraction
Online-Zugang:	Volltext
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