Role of apical caspases and glucocorticoid-regulated genes in glucocorticoid-induced apoptosis of pre-B leukemic cells

Glucocorticoid (GC) sensitivity in hematopoietic cells requires the activation and nuclear translocation of the glucocorticoid receptor (GR) and the subsequent activation of caspases. To gain insight into the caspase cascade responsible for the execution phase of GC-induced apoptosis, 697 pre-B leuk...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003, Vol.63 (1), p.172-178
Hauptverfasser:	PLANEY, Sonia L, ABRAMS, Marc T, ROBERTSON, Noreen M, LITWACK, Gerald
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Caspases - metabolism Cell Survival Chemotherapy Clone Cells DNA Primers Gene Expression Regulation, Neoplastic - drug effects Glucocorticoids - pharmacology Humans JNK Mitogen-Activated Protein Kinases Kinetics Leukemia, B-Cell - genetics Leukemia, B-Cell - pathology Medical sciences Mitogen-Activated Protein Kinases - metabolism Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Preleukemia - genetics Preleukemia - pathology Reverse Transcriptase Polymerase Chain Reaction Transfection Tumor Cells, Cultured
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