Hibernating Myocardium Retains Metabolic and Contractile Reserve Despite Regional Reductions in Flow, Function, and Oxygen Consumption at Rest

ABSTRACT—Hibernating myocardium, characterized by reductions in flow and function at rest, has limited contractile reserve in response to increases in external workload. We hypothesized that this attenuation of function reflects an adaptive downregulation that prevents the development of metabolic e...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2003-01, Vol.92 (1), p.48-55
Hauptverfasser:	Fallavollita, James A, Malm, Brian J, Canty, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Adrenergic beta-Agonists - pharmacology Animals Biological and medical sciences Blood Flow Velocity - drug effects Blood Pressure - drug effects Cardiac Pacing, Artificial Coronary Circulation - drug effects Coronary Circulation - physiology Coronary Stenosis - complications Coronary Stenosis - physiopathology Disease Models, Animal Down-Regulation Epinephrine - pharmacology Fundamental and applied biological sciences. Psychology Heart Heart Function Tests - drug effects Heart Rate - drug effects Lactic Acid - pharmacokinetics Microspheres Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocardial Stunning - complications Myocardial Stunning - physiopathology Oxygen Consumption - drug effects Oxygen Consumption - physiology Radionuclide Ventriculography Swine Vertebrates: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!