Autologous bone-marrow stem-cell transplantation for myocardial regeneration
Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5×10 6 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary ar...
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| Veröffentlicht in: | The Lancet (British edition) 2003-01, Vol.361 (9351), p.45-46 |
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| container_issue | 9351 |
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| container_title | The Lancet (British edition) |
| container_volume | 361 |
| creator | Stamm, Christof Westphal, Bernd Kleine, Hans-Dieter Petzsch, Michael Kittner, Christian Klinge, Heiko Schümichen, Carl Nienaber, Christoph A Freund, Mathias Steinhoff, Gustav |
| description | Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5×10
6 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3–9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium. |
| doi_str_mv | 10.1016/S0140-6736(03)12110-1 |
| format | Article |
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6 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3–9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12517467</pmid><doi>10.1016/S0140-6736(03)12110-1</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2003-01, Vol.361 (9351), p.45-46 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | MEDLINE; EBSCOhost Business Source Complete; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Aged Angioplasty, Balloon, Coronary Cardiovascular Agents - therapeutic use Coronary Artery Bypass Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Myocardial Infarction - complications Myocardial Infarction - drug therapy Myocardial Infarction - therapy |
| title | Autologous bone-marrow stem-cell transplantation for myocardial regeneration |
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