Transgenic silkworms produce recombinant human type III procollagen in cocoons

We describe the generation of transgenic silkworms that produce cocoons containing recombinant human collagen. A fusion cDNA was constructed encoding a protein that incorporated a human type III procollagen mini-chain with C-propeptide deleted, a fibroin light chain (L-chain), and an enhanced green...

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Veröffentlicht in:	Nature biotechnology 2003-01, Vol.21 (1), p.52-56
Hauptverfasser:	Tomita, Masahiro, Munetsuna, Hiroto, Sato, Tsutomu, Adachi, Takahiro, Hino, Rika, Hayashi, Masahiro, Shimizu, Katsuhiko, Nakamura, Namiko, Tamura, Toshiki, Yoshizato, Katsutoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino acids Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - metabolism Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Bombyx - genetics Bombyx - metabolism Collagen Type III - biosynthesis Collagen Type III - genetics Collagen Type III - isolation & purification Collagen Type III - therapeutic use Drug Delivery Systems - methods Eggs Feasibility Studies Fibroins - biosynthesis Fibroins - genetics Fluorescence Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics Genetic engineering Genetic technics Green Fluorescent Proteins Humans Insect Proteins - biosynthesis Insect Proteins - genetics Life Sciences Luminescent Proteins - biosynthesis Luminescent Proteins - genetics Methods. Procedures. Technologies Proteins Proteomics - methods Pupa - metabolism Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - isolation & purification Tissue Engineering - instrumentation Tissue Engineering - methods Transgenic animals Transgenic animals and transgenic plants
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