Interleukin 2 production in iron deficient-children
The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children's health centers in the Paris are...
Gespeichert in:
| Veröffentlicht in: | Biological trace element research 1992-01, Vol.32 (1-3), p.421-426 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 426 |
|---|---|
| container_issue | 1-3 |
| container_start_page | 421 |
| container_title | Biological trace element research |
| container_volume | 32 |
| creator | Galan, P. (Institute Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France) Thibault, H Preziosi, P Hercberg, S |
| description | The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children's health centers in the Paris area. Iron deficiency was defined by the existence of at least two abnormal values among the three indicators of iron status: serum ferritin level less than or equal to 12 micrograms/L, transferrin saturation less than 12%, and erythrocyte protoporphyrin concentration greater than 3 micrograms/g hemoglobin. According to this definition, 53 children were classified as iron deficient and 28 as iron sufficient. No differences were observed between the iron-deficient and iron-sufficient groups in terms of the IL-2 concentration without stimulation by PHA. IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children. The reduction in IL-2 production by activated lymphocytes observed in our study of iron-deficient children may be responsible for impairments in immunity found by other authors, particularly in cell-mediated immunity. |
| doi_str_mv | 10.1007/BF02784628 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72950863</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72950863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-c1faee9a6a5681a1229ddbd1f61adbc26e97c8b1e97d5ff178a7b2c5b2dc2cb43</originalsourceid><addsrcrecordid>eNpFkM1LAzEQxYMotVYvHgWhB_EgrGaS3Xwca7FaKHjQnpdsPjS63a3J7sH_3pQt9vQY5sebeQ-hS8D3gDF_eFxgwkXOiDhCYygKmWFO8DEaY2A0y6XIT9FZjF8YAyeSjtAIKC-wyMeILpvOhtr2376Zkuk2tKbXnW-baZp9SGqs89rbpsv0p69NsM05OnGqjvZirxO0Xjy9z1-y1evzcj5bZZoylnBwylqpmCqYAAWESGMqA46BMpUmzEquRQVJTOEccKF4RXRREaOJrnI6QbeDb_rqp7exKzc-alvXqrFtH8uUJYVgNIF3A6hDG2OwrtwGv1HhtwRc7hoqDw0l-Hrv2lcbaw7oUEna3-z3KmpVu6Aa7eM_VlCWC7y7eTVgTrWl-ggJWb9JkMAwp395unU6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72950863</pqid></control><display><type>article</type><title>Interleukin 2 production in iron deficient-children</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Galan, P. (Institute Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France) ; Thibault, H ; Preziosi, P ; Hercberg, S</creator><creatorcontrib>Galan, P. (Institute Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France) ; Thibault, H ; Preziosi, P ; Hercberg, S</creatorcontrib><description>The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children's health centers in the Paris area. Iron deficiency was defined by the existence of at least two abnormal values among the three indicators of iron status: serum ferritin level less than or equal to 12 micrograms/L, transferrin saturation less than 12%, and erythrocyte protoporphyrin concentration greater than 3 micrograms/g hemoglobin. According to this definition, 53 children were classified as iron deficient and 28 as iron sufficient. No differences were observed between the iron-deficient and iron-sufficient groups in terms of the IL-2 concentration without stimulation by PHA. IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children. The reduction in IL-2 production by activated lymphocytes observed in our study of iron-deficient children may be responsible for impairments in immunity found by other authors, particularly in cell-mediated immunity.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/BF02784628</identifier><identifier>PMID: 1375084</identifier><identifier>CODEN: BTERDG</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Anemia, Hypochromic - blood ; Anemia, Hypochromic - metabolism ; Biological and medical sciences ; BIOSINTESIS ; BIOSYNTHESE ; BIOSYNTHESIS ; CARENCE MINERALE ; Cell Communication - physiology ; Child, Preschool ; DEFICIENCIA DE MINERALES ; DIET ; DIETA ; FACTEUR IMMUNOLOGIQUE ; FACTORES INMUNOLOGICOS ; FER ; Hemoglobins - analysis ; HIERRO ; Humans ; IMMUNOLOGICAL FACTORS ; Infant ; Interleukin-2 - biosynthesis ; IRON ; Iron - deficiency ; Lymphocytes - cytology ; Lymphocytes - metabolism ; Medical sciences ; Metabolic diseases ; Metals (hemochromatosis...) ; MINERAL DEFICIENCIES ; Other metabolic disorders ; REGIME ALIMENTAIRE ; T-Lymphocyte Subsets - metabolism</subject><ispartof>Biological trace element research, 1992-01, Vol.32 (1-3), p.421-426</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-c1faee9a6a5681a1229ddbd1f61adbc26e97c8b1e97d5ff178a7b2c5b2dc2cb43</citedby><cites>FETCH-LOGICAL-c366t-c1faee9a6a5681a1229ddbd1f61adbc26e97c8b1e97d5ff178a7b2c5b2dc2cb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,4050,4051,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5364803$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1375084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galan, P. (Institute Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France)</creatorcontrib><creatorcontrib>Thibault, H</creatorcontrib><creatorcontrib>Preziosi, P</creatorcontrib><creatorcontrib>Hercberg, S</creatorcontrib><title>Interleukin 2 production in iron deficient-children</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children's health centers in the Paris area. Iron deficiency was defined by the existence of at least two abnormal values among the three indicators of iron status: serum ferritin level less than or equal to 12 micrograms/L, transferrin saturation less than 12%, and erythrocyte protoporphyrin concentration greater than 3 micrograms/g hemoglobin. According to this definition, 53 children were classified as iron deficient and 28 as iron sufficient. No differences were observed between the iron-deficient and iron-sufficient groups in terms of the IL-2 concentration without stimulation by PHA. IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children. The reduction in IL-2 production by activated lymphocytes observed in our study of iron-deficient children may be responsible for impairments in immunity found by other authors, particularly in cell-mediated immunity.</description><subject>Anemia, Hypochromic - blood</subject><subject>Anemia, Hypochromic - metabolism</subject><subject>Biological and medical sciences</subject><subject>BIOSINTESIS</subject><subject>BIOSYNTHESE</subject><subject>BIOSYNTHESIS</subject><subject>CARENCE MINERALE</subject><subject>Cell Communication - physiology</subject><subject>Child, Preschool</subject><subject>DEFICIENCIA DE MINERALES</subject><subject>DIET</subject><subject>DIETA</subject><subject>FACTEUR IMMUNOLOGIQUE</subject><subject>FACTORES INMUNOLOGICOS</subject><subject>FER</subject><subject>Hemoglobins - analysis</subject><subject>HIERRO</subject><subject>Humans</subject><subject>IMMUNOLOGICAL FACTORS</subject><subject>Infant</subject><subject>Interleukin-2 - biosynthesis</subject><subject>IRON</subject><subject>Iron - deficiency</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - metabolism</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metals (hemochromatosis...)</subject><subject>MINERAL DEFICIENCIES</subject><subject>Other metabolic disorders</subject><subject>REGIME ALIMENTAIRE</subject><subject>T-Lymphocyte Subsets - metabolism</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LAzEQxYMotVYvHgWhB_EgrGaS3Xwca7FaKHjQnpdsPjS63a3J7sH_3pQt9vQY5sebeQ-hS8D3gDF_eFxgwkXOiDhCYygKmWFO8DEaY2A0y6XIT9FZjF8YAyeSjtAIKC-wyMeILpvOhtr2376Zkuk2tKbXnW-baZp9SGqs89rbpsv0p69NsM05OnGqjvZirxO0Xjy9z1-y1evzcj5bZZoylnBwylqpmCqYAAWESGMqA46BMpUmzEquRQVJTOEccKF4RXRREaOJrnI6QbeDb_rqp7exKzc-alvXqrFtH8uUJYVgNIF3A6hDG2OwrtwGv1HhtwRc7hoqDw0l-Hrv2lcbaw7oUEna3-z3KmpVu6Aa7eM_VlCWC7y7eTVgTrWl-ggJWb9JkMAwp395unU6</recordid><startdate>199201</startdate><enddate>199201</enddate><creator>Galan, P. (Institute Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France)</creator><creator>Thibault, H</creator><creator>Preziosi, P</creator><creator>Hercberg, S</creator><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199201</creationdate><title>Interleukin 2 production in iron deficient-children</title><author>Galan, P. (Institute Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France) ; Thibault, H ; Preziosi, P ; Hercberg, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-c1faee9a6a5681a1229ddbd1f61adbc26e97c8b1e97d5ff178a7b2c5b2dc2cb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Anemia, Hypochromic - blood</topic><topic>Anemia, Hypochromic - metabolism</topic><topic>Biological and medical sciences</topic><topic>BIOSINTESIS</topic><topic>BIOSYNTHESE</topic><topic>BIOSYNTHESIS</topic><topic>CARENCE MINERALE</topic><topic>Cell Communication - physiology</topic><topic>Child, Preschool</topic><topic>DEFICIENCIA DE MINERALES</topic><topic>DIET</topic><topic>DIETA</topic><topic>FACTEUR IMMUNOLOGIQUE</topic><topic>FACTORES INMUNOLOGICOS</topic><topic>FER</topic><topic>Hemoglobins - analysis</topic><topic>HIERRO</topic><topic>Humans</topic><topic>IMMUNOLOGICAL FACTORS</topic><topic>Infant</topic><topic>Interleukin-2 - biosynthesis</topic><topic>IRON</topic><topic>Iron - deficiency</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - metabolism</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metals (hemochromatosis...)</topic><topic>MINERAL DEFICIENCIES</topic><topic>Other metabolic disorders</topic><topic>REGIME ALIMENTAIRE</topic><topic>T-Lymphocyte Subsets - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galan, P. (Institute Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France)</creatorcontrib><creatorcontrib>Thibault, H</creatorcontrib><creatorcontrib>Preziosi, P</creatorcontrib><creatorcontrib>Hercberg, S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galan, P. (Institute Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France)</au><au>Thibault, H</au><au>Preziosi, P</au><au>Hercberg, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin 2 production in iron deficient-children</atitle><jtitle>Biological trace element research</jtitle><addtitle>Biol Trace Elem Res</addtitle><date>1992-01</date><risdate>1992</risdate><volume>32</volume><issue>1-3</issue><spage>421</spage><epage>426</epage><pages>421-426</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><coden>BTERDG</coden><abstract>The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children's health centers in the Paris area. Iron deficiency was defined by the existence of at least two abnormal values among the three indicators of iron status: serum ferritin level less than or equal to 12 micrograms/L, transferrin saturation less than 12%, and erythrocyte protoporphyrin concentration greater than 3 micrograms/g hemoglobin. According to this definition, 53 children were classified as iron deficient and 28 as iron sufficient. No differences were observed between the iron-deficient and iron-sufficient groups in terms of the IL-2 concentration without stimulation by PHA. IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children. The reduction in IL-2 production by activated lymphocytes observed in our study of iron-deficient children may be responsible for impairments in immunity found by other authors, particularly in cell-mediated immunity.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>1375084</pmid><doi>10.1007/BF02784628</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4984 |
| ispartof | Biological trace element research, 1992-01, Vol.32 (1-3), p.421-426 |
| issn | 0163-4984 1559-0720 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72950863 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Anemia, Hypochromic - blood Anemia, Hypochromic - metabolism Biological and medical sciences BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS CARENCE MINERALE Cell Communication - physiology Child, Preschool DEFICIENCIA DE MINERALES DIET DIETA FACTEUR IMMUNOLOGIQUE FACTORES INMUNOLOGICOS FER Hemoglobins - analysis HIERRO Humans IMMUNOLOGICAL FACTORS Infant Interleukin-2 - biosynthesis IRON Iron - deficiency Lymphocytes - cytology Lymphocytes - metabolism Medical sciences Metabolic diseases Metals (hemochromatosis...) MINERAL DEFICIENCIES Other metabolic disorders REGIME ALIMENTAIRE T-Lymphocyte Subsets - metabolism |
| title | Interleukin 2 production in iron deficient-children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T19%3A42%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin%202%20production%20in%20iron%20deficient-children&rft.jtitle=Biological%20trace%20element%20research&rft.au=Galan,%20P.%20(Institute%20Scientifique%20et%20Technique%20de%20la%20Nutrition%20et%20de%20l'Alimentation,%20Paris,%20France)&rft.date=1992-01&rft.volume=32&rft.issue=1-3&rft.spage=421&rft.epage=426&rft.pages=421-426&rft.issn=0163-4984&rft.eissn=1559-0720&rft.coden=BTERDG&rft_id=info:doi/10.1007/BF02784628&rft_dat=%3Cproquest_cross%3E72950863%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72950863&rft_id=info:pmid/1375084&rfr_iscdi=true |