Regulation of Channel Gating by AMP-activated Protein Kinase Modulates Cystic Fibrosis Transmembrane Conductance Regulator Activity in Lung Submucosal Cells

Cystic fibrosis transmembrane conductance regulator (CFTR) Cl−channel activity is important for fluid and electrolyte transport in many epithelia including the lung, the site of most cystic fibrosis-associated morbidity. CFTR is unique among ion channels in requiring ATP hydrolysis for its gating, s...

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Veröffentlicht in:	The Journal of biological chemistry 2003-01, Vol.278 (2), p.998-1004
Hauptverfasser:	Hallows, Kenneth R., McCane, Jill E., Kemp, Bruce E., Witters, Lee A., Foskett, J. Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP-Activated Protein Kinases Animals Cell Polarity CHO Cells Cricetinae Cystic Fibrosis Transmembrane Conductance Regulator - physiology Humans Ion Channel Gating - physiology Lung - metabolism Multienzyme Complexes - physiology Protein-Serine-Threonine Kinases - physiology Ribonucleotides - pharmacology
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