The TaqIB and −629C>A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey
The Singapore population comprises Chinese, Malays and Asian Indians. Within this population, Asian Indians have the highest rates of coronary heart disease, whereas Chinese have the lowest. Conversely, Indians have the lowest high‐density lipoprotein cholesterol (HDL‐C) concentrations, followed by...
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| Veröffentlicht in: | Clinical genetics 2003-01, Vol.63 (1), p.19-30 |
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| creator | Tai, ES Ordovas, JM Corella, D Deurenberg-Yap, M Chan, E Adiconis, X Chew, SK Loh, LM Tan, CE |
| description | The Singapore population comprises Chinese, Malays and Asian Indians. Within this population, Asian Indians have the highest rates of coronary heart disease, whereas Chinese have the lowest. Conversely, Indians have the lowest high‐density lipoprotein cholesterol (HDL‐C) concentrations, followed by Malays and Chinese. We studied the TaqIB and −629C>A polymorphisms at the CETP locus in 1300 Chinese, 364 Malay and 282 Asian Indian men, and in 1558 Chinese, 397 Malay and 306 Asian Indian women, to determine whether these polymorphisms are responsible for the ethnic difference in HDL‐C concentration. The frequency of the B2 allele in Chinese, Malays and Indians was 0.384, 0.339 and 0.449 in men, and 0.379, 0.329 and 0.415 in women, respectively (p |
| doi_str_mv | 10.1034/j.1399-0004.2003.630104.x |
| format | Article |
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The 1998 Singapore National Health Survey</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Tai, ES ; Ordovas, JM ; Corella, D ; Deurenberg-Yap, M ; Chan, E ; Adiconis, X ; Chew, SK ; Loh, LM ; Tan, CE</creator><creatorcontrib>Tai, ES ; Ordovas, JM ; Corella, D ; Deurenberg-Yap, M ; Chan, E ; Adiconis, X ; Chew, SK ; Loh, LM ; Tan, CE</creatorcontrib><description>The Singapore population comprises Chinese, Malays and Asian Indians. Within this population, Asian Indians have the highest rates of coronary heart disease, whereas Chinese have the lowest. Conversely, Indians have the lowest high‐density lipoprotein cholesterol (HDL‐C) concentrations, followed by Malays and Chinese. We studied the TaqIB and −629C>A polymorphisms at the CETP locus in 1300 Chinese, 364 Malay and 282 Asian Indian men, and in 1558 Chinese, 397 Malay and 306 Asian Indian women, to determine whether these polymorphisms are responsible for the ethnic difference in HDL‐C concentration. The frequency of the B2 allele in Chinese, Malays and Indians was 0.384, 0.339 and 0.449 in men, and 0.379, 0.329 and 0.415 in women, respectively (p < 0.001). For the A‐629 allele, the relative frequencies were 0.477, 0.423 and 0.592 in men and 0.486, 0.416 and 0.575 in women (p < 0.001). The two polymorphisms were in linkage disequilibrium (D / Dmax= 0.9772, p < 0.00001). The B2 and the A‐629 alleles were associated with increased HDL‐C concentrations in a dose‐dependent manner. The B2 allele continued to show an association with HDL‐C concentration, even after controlling for the genotype at position −629. Dietary cholesterol showed a significant interaction with the TaqIB polymorphism in determining HDL‐C concentrations in Indians and Malays, but not in Chinese. In conclusion, the high frequencies of these polymorphisms in Asian Indians could not explain the observed ethnic differences in HDL‐C concentration. Moreover, we observed an ethnic‐specific interaction among dietary cholesterol, the TaqIB polymorphism and HDL‐C concentrations.</description><identifier>ISSN: 0009-9163</identifier><identifier>EISSN: 1399-0004</identifier><identifier>DOI: 10.1034/j.1399-0004.2003.630104.x</identifier><identifier>PMID: 12519368</identifier><identifier>CODEN: CLGNAY</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Alcohol Drinking - epidemiology ; Biological and medical sciences ; Carrier Proteins - genetics ; Cholesterol Ester Transfer Proteins ; Cholesterol, HDL - blood ; cholesteryl ester transfer protein ; Diabetes Mellitus - epidemiology ; Disorders of blood lipids. 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The 1998 Singapore National Health Survey</title><title>Clinical genetics</title><addtitle>Clin Genet</addtitle><description>The Singapore population comprises Chinese, Malays and Asian Indians. Within this population, Asian Indians have the highest rates of coronary heart disease, whereas Chinese have the lowest. Conversely, Indians have the lowest high‐density lipoprotein cholesterol (HDL‐C) concentrations, followed by Malays and Chinese. We studied the TaqIB and −629C>A polymorphisms at the CETP locus in 1300 Chinese, 364 Malay and 282 Asian Indian men, and in 1558 Chinese, 397 Malay and 306 Asian Indian women, to determine whether these polymorphisms are responsible for the ethnic difference in HDL‐C concentration. The frequency of the B2 allele in Chinese, Malays and Indians was 0.384, 0.339 and 0.449 in men, and 0.379, 0.329 and 0.415 in women, respectively (p < 0.001). For the A‐629 allele, the relative frequencies were 0.477, 0.423 and 0.592 in men and 0.486, 0.416 and 0.575 in women (p < 0.001). The two polymorphisms were in linkage disequilibrium (D / Dmax= 0.9772, p < 0.00001). The B2 and the A‐629 alleles were associated with increased HDL‐C concentrations in a dose‐dependent manner. The B2 allele continued to show an association with HDL‐C concentration, even after controlling for the genotype at position −629. Dietary cholesterol showed a significant interaction with the TaqIB polymorphism in determining HDL‐C concentrations in Indians and Malays, but not in Chinese. In conclusion, the high frequencies of these polymorphisms in Asian Indians could not explain the observed ethnic differences in HDL‐C concentration. Moreover, we observed an ethnic‐specific interaction among dietary cholesterol, the TaqIB polymorphism and HDL‐C concentrations.</description><subject>Alcohol Drinking - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Cholesterol Ester Transfer Proteins</subject><subject>Cholesterol, HDL - blood</subject><subject>cholesteryl ester transfer protein</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Disorders of blood lipids. Hyperlipoproteinemia</subject><subject>ethnic groups</subject><subject>Exercise</subject><subject>Female</subject><subject>Glycoproteins</subject><subject>HDL</subject><subject>Humans</subject><subject>lipoproteins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Polymorphism, Genetic</subject><subject>Singapore - epidemiology</subject><subject>Singapore - ethnology</subject><subject>Smoking - epidemiology</subject><issn>0009-9163</issn><issn>1399-0004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9u1DAQxiMEokvhFZA5wC3BjhM75oAoq7ItKkWoCxytieOwXpw_tZN29w048zw8DU-Cd7Nqr5xmrPn5mxl_jqIXBCcE0-z1OiFUiBhjnCUpxjRhFJOQbx5Es7vKw2gWgogFYfQoeuL9Ohwpz8Xj6IikORGUFbPoz3Kl0RKuz98jaCv099dvlor52xPUd3bbdK5fGd94BAMaAqhWndV-0G5r0T6iwUHr65D0rhu0aZHt1OjfIPC-UwYG07Ue3ZphhazpTYWsvtHWowACakY7GD2sWqNCu360ezxBu5GIEAW6Mu0P6Dun0eW-BBadabBB7Gp0N3r7NHpUg_X62SEeR18_nC7nZ_HF58X5_OQiVpTjLK4w15rVrMYV1lxnvMacZ1BmJbACuMhrTkqFma4ECMjyvBJlinmBVcko1IoeR68m3bDk9RgWl43xSlsLre5GL3kqsjAvC6CYQOU6752uZe9MA24rCZY76-Ra7gySO4Pkzjo5WSc34e7zQ5OxbHR1f_PgVQBeHgDwCmwdXl4Zf89lLE0LwgP3buJujdXb_59AzhenUx4k4knCBJM3dxLgfkrGwx-S3y8X8lP6rfgoxBeJ6T9AVchF</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Tai, ES</creator><creator>Ordovas, JM</creator><creator>Corella, D</creator><creator>Deurenberg-Yap, M</creator><creator>Chan, E</creator><creator>Adiconis, X</creator><creator>Chew, SK</creator><creator>Loh, LM</creator><creator>Tan, CE</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>The TaqIB and −629C>A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey</title><author>Tai, ES ; Ordovas, JM ; Corella, D ; Deurenberg-Yap, M ; Chan, E ; Adiconis, X ; Chew, SK ; Loh, LM ; Tan, CE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3704-d07ee6f6f0d0e7e47f0774ab4ba68a795f71bc06ed9a9a455d9b20780cb63afc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alcohol Drinking - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Cholesterol Ester Transfer Proteins</topic><topic>Cholesterol, HDL - blood</topic><topic>cholesteryl ester transfer protein</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Disorders of blood lipids. Hyperlipoproteinemia</topic><topic>ethnic groups</topic><topic>Exercise</topic><topic>Female</topic><topic>Glycoproteins</topic><topic>HDL</topic><topic>Humans</topic><topic>lipoproteins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Polymorphism, Genetic</topic><topic>Singapore - epidemiology</topic><topic>Singapore - ethnology</topic><topic>Smoking - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tai, ES</creatorcontrib><creatorcontrib>Ordovas, JM</creatorcontrib><creatorcontrib>Corella, D</creatorcontrib><creatorcontrib>Deurenberg-Yap, M</creatorcontrib><creatorcontrib>Chan, E</creatorcontrib><creatorcontrib>Adiconis, X</creatorcontrib><creatorcontrib>Chew, SK</creatorcontrib><creatorcontrib>Loh, LM</creatorcontrib><creatorcontrib>Tan, CE</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tai, ES</au><au>Ordovas, JM</au><au>Corella, D</au><au>Deurenberg-Yap, M</au><au>Chan, E</au><au>Adiconis, X</au><au>Chew, SK</au><au>Loh, LM</au><au>Tan, CE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The TaqIB and −629C>A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey</atitle><jtitle>Clinical genetics</jtitle><addtitle>Clin Genet</addtitle><date>2003-01</date><risdate>2003</risdate><volume>63</volume><issue>1</issue><spage>19</spage><epage>30</epage><pages>19-30</pages><issn>0009-9163</issn><eissn>1399-0004</eissn><coden>CLGNAY</coden><abstract>The Singapore population comprises Chinese, Malays and Asian Indians. Within this population, Asian Indians have the highest rates of coronary heart disease, whereas Chinese have the lowest. Conversely, Indians have the lowest high‐density lipoprotein cholesterol (HDL‐C) concentrations, followed by Malays and Chinese. We studied the TaqIB and −629C>A polymorphisms at the CETP locus in 1300 Chinese, 364 Malay and 282 Asian Indian men, and in 1558 Chinese, 397 Malay and 306 Asian Indian women, to determine whether these polymorphisms are responsible for the ethnic difference in HDL‐C concentration. The frequency of the B2 allele in Chinese, Malays and Indians was 0.384, 0.339 and 0.449 in men, and 0.379, 0.329 and 0.415 in women, respectively (p < 0.001). For the A‐629 allele, the relative frequencies were 0.477, 0.423 and 0.592 in men and 0.486, 0.416 and 0.575 in women (p < 0.001). The two polymorphisms were in linkage disequilibrium (D / Dmax= 0.9772, p < 0.00001). The B2 and the A‐629 alleles were associated with increased HDL‐C concentrations in a dose‐dependent manner. The B2 allele continued to show an association with HDL‐C concentration, even after controlling for the genotype at position −629. Dietary cholesterol showed a significant interaction with the TaqIB polymorphism in determining HDL‐C concentrations in Indians and Malays, but not in Chinese. In conclusion, the high frequencies of these polymorphisms in Asian Indians could not explain the observed ethnic differences in HDL‐C concentration. Moreover, we observed an ethnic‐specific interaction among dietary cholesterol, the TaqIB polymorphism and HDL‐C concentrations.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>12519368</pmid><doi>10.1034/j.1399-0004.2003.630104.x</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alcohol Drinking - epidemiology Biological and medical sciences Carrier Proteins - genetics Cholesterol Ester Transfer Proteins Cholesterol, HDL - blood cholesteryl ester transfer protein Diabetes Mellitus - epidemiology Disorders of blood lipids. Hyperlipoproteinemia ethnic groups Exercise Female Glycoproteins HDL Humans lipoproteins Male Medical sciences Metabolic diseases Polymorphism, Genetic Singapore - epidemiology Singapore - ethnology Smoking - epidemiology |
| title | The TaqIB and −629C>A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey |
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