Administration of carbachol into the lateral ventricle and suprachiasmatic nucleus (SCN) produces dose-dependent phase shifts in the circadian rhythm of locomotor activity
The cholinergic agonist, carbachol, induces phase-dependent shifts in the timing of the circadian rhythm of locomotor activity (CRLA). The effects of carbachol injections into the lateral ventricles of hamsters were compared between circadian times that produce phase delays vs. phase advances in the...
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| Veröffentlicht in: | Neuroscience letters 1992-03, Vol.137 (2), p.211-215 |
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| container_title | Neuroscience letters |
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| creator | Wee, Beth E.F. Anderson, Keith D. Kouchis, Nick S. Turek, Fred W. |
| description | The cholinergic agonist, carbachol, induces phase-dependent shifts in the timing of the circadian rhythm of locomotor activity (CRLA). The effects of carbachol injections into the lateral ventricles of hamsters were compared between circadian times that produce phase delays vs. phase advances in the CRLA. The shape of the dose-response curves and the ED
50 for carbachol injections were similar for the two injection times. The second experiment demonstrated the dose-dependence of phase advances produced by carbachol injections into the area of the suprachiasmatic nucleus. These results indicate that carbachol exerts similar dose-dependent actions for both phase advances and phase delays. |
| doi_str_mv | 10.1016/0304-3940(92)90406-W |
| format | Article |
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50 for carbachol injections were similar for the two injection times. The second experiment demonstrated the dose-dependence of phase advances produced by carbachol injections into the area of the suprachiasmatic nucleus. These results indicate that carbachol exerts similar dose-dependent actions for both phase advances and phase delays.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(92)90406-W</identifier><identifier>PMID: 1584462</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acetylcholine ; Acetylcholine - administration & dosage ; Acetylcholine - pharmacology ; Animals ; Carbachol ; Carbachol - administration & dosage ; Carbachol - pharmacology ; Circadian rhythm ; Circadian Rhythm - drug effects ; Cricetinae ; Dose-response curve ; Dose-Response Relationship, Drug ; Injections ; Injections, Intraventricular ; Lateral ventricle ; Locomotor activity ; Male ; Mesocricetus ; Mesocricetus auratus ; Motor Activity - drug effects ; Phase shift ; Suprachiasmatic Nucleus</subject><ispartof>Neuroscience letters, 1992-03, Vol.137 (2), p.211-215</ispartof><rights>1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-ee923a13447c2a239bc333ec191a397036c83b33f87523d52b1c5df31e5427173</citedby><cites>FETCH-LOGICAL-c388t-ee923a13447c2a239bc333ec191a397036c83b33f87523d52b1c5df31e5427173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030439409290406W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1584462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wee, Beth E.F.</creatorcontrib><creatorcontrib>Anderson, Keith D.</creatorcontrib><creatorcontrib>Kouchis, Nick S.</creatorcontrib><creatorcontrib>Turek, Fred W.</creatorcontrib><title>Administration of carbachol into the lateral ventricle and suprachiasmatic nucleus (SCN) produces dose-dependent phase shifts in the circadian rhythm of locomotor activity</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The cholinergic agonist, carbachol, induces phase-dependent shifts in the timing of the circadian rhythm of locomotor activity (CRLA). The effects of carbachol injections into the lateral ventricles of hamsters were compared between circadian times that produce phase delays vs. phase advances in the CRLA. The shape of the dose-response curves and the ED
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These results indicate that carbachol exerts similar dose-dependent actions for both phase advances and phase delays.</description><subject>Acetylcholine</subject><subject>Acetylcholine - administration & dosage</subject><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Carbachol</subject><subject>Carbachol - administration & dosage</subject><subject>Carbachol - pharmacology</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - drug effects</subject><subject>Cricetinae</subject><subject>Dose-response curve</subject><subject>Dose-Response Relationship, Drug</subject><subject>Injections</subject><subject>Injections, Intraventricular</subject><subject>Lateral ventricle</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Mesocricetus</subject><subject>Mesocricetus auratus</subject><subject>Motor Activity - drug effects</subject><subject>Phase shift</subject><subject>Suprachiasmatic Nucleus</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhi0EKkPhDUDyCrWLgG-J4w1SNSq0UgULQF1ajn2iGCV2sJ2R5pl4SZJOBTtYncV_Ocf-EHpNyTtKaPOecCIqrgS5UOxSEUGa6v4J2tFWskoqyZ6i3R_Lc_Qi5x-EkJrW4gyd0boVomE79OvKTT74XJIpPgYce2xN6owd4oh9KBGXAfBoCiQz4gOEkrwdAZvgcF7mtBq9ydMatjgsq7JkfPF1__kSzym6xULGLmaoHMwQ3BrH82Ay4Dz4vuR1w0O_9cka503AaTiWYdrOGKONUywxYWOLP_hyfIme9WbM8OpxnqPvH6-_7W-quy-fbvdXd5XlbVsqAMW4oVwIaZlhXHWWcw6WKmq4koQ3tuUd530ra8ZdzTpqa9dzCrVgkkp-jt6eetcn_FwgFz35bGEcTYC4ZC2ZEq1smv8aacM4V2xrFCejTTHnBL2ek59MOmpK9AZTb6T0Rkorph9g6vs19uaxf-kmcH9DJ3qr_uGkw_obBw9JZ-shWHA-gS3aRf_vBb8BthCxXg</recordid><startdate>19920330</startdate><enddate>19920330</enddate><creator>Wee, Beth E.F.</creator><creator>Anderson, Keith D.</creator><creator>Kouchis, Nick S.</creator><creator>Turek, Fred W.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920330</creationdate><title>Administration of carbachol into the lateral ventricle and suprachiasmatic nucleus (SCN) produces dose-dependent phase shifts in the circadian rhythm of locomotor activity</title><author>Wee, Beth E.F. ; Anderson, Keith D. ; Kouchis, Nick S. ; Turek, Fred W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-ee923a13447c2a239bc333ec191a397036c83b33f87523d52b1c5df31e5427173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acetylcholine</topic><topic>Acetylcholine - administration & dosage</topic><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Carbachol</topic><topic>Carbachol - administration & dosage</topic><topic>Carbachol - pharmacology</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - drug effects</topic><topic>Cricetinae</topic><topic>Dose-response curve</topic><topic>Dose-Response Relationship, Drug</topic><topic>Injections</topic><topic>Injections, Intraventricular</topic><topic>Lateral ventricle</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Mesocricetus</topic><topic>Mesocricetus auratus</topic><topic>Motor Activity - drug effects</topic><topic>Phase shift</topic><topic>Suprachiasmatic Nucleus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wee, Beth E.F.</creatorcontrib><creatorcontrib>Anderson, Keith D.</creatorcontrib><creatorcontrib>Kouchis, Nick S.</creatorcontrib><creatorcontrib>Turek, Fred W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wee, Beth E.F.</au><au>Anderson, Keith D.</au><au>Kouchis, Nick S.</au><au>Turek, Fred W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Administration of carbachol into the lateral ventricle and suprachiasmatic nucleus (SCN) produces dose-dependent phase shifts in the circadian rhythm of locomotor activity</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1992-03-30</date><risdate>1992</risdate><volume>137</volume><issue>2</issue><spage>211</spage><epage>215</epage><pages>211-215</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>The cholinergic agonist, carbachol, induces phase-dependent shifts in the timing of the circadian rhythm of locomotor activity (CRLA). The effects of carbachol injections into the lateral ventricles of hamsters were compared between circadian times that produce phase delays vs. phase advances in the CRLA. The shape of the dose-response curves and the ED
50 for carbachol injections were similar for the two injection times. The second experiment demonstrated the dose-dependence of phase advances produced by carbachol injections into the area of the suprachiasmatic nucleus. These results indicate that carbachol exerts similar dose-dependent actions for both phase advances and phase delays.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>1584462</pmid><doi>10.1016/0304-3940(92)90406-W</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1992-03, Vol.137 (2), p.211-215 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72948766 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholine Acetylcholine - administration & dosage Acetylcholine - pharmacology Animals Carbachol Carbachol - administration & dosage Carbachol - pharmacology Circadian rhythm Circadian Rhythm - drug effects Cricetinae Dose-response curve Dose-Response Relationship, Drug Injections Injections, Intraventricular Lateral ventricle Locomotor activity Male Mesocricetus Mesocricetus auratus Motor Activity - drug effects Phase shift Suprachiasmatic Nucleus |
| title | Administration of carbachol into the lateral ventricle and suprachiasmatic nucleus (SCN) produces dose-dependent phase shifts in the circadian rhythm of locomotor activity |
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