Leigh's disease presenting as an intramedullary mass lesion
An unusual presentation of Leigh's disease consisting of rapid progression of leg weakness in a young child is discussed. Magnetic resonance imaging revealed an intramedullary mass lesion of the conus medullaris. Surgical exploration revealed only necrosis and inflammation. Subsequent studies r...
Gespeichert in:
| Veröffentlicht in: | Neurosurgery 1992-05, Vol.30 (5), p.774-776 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 776 |
|---|---|
| container_issue | 5 |
| container_start_page | 774 |
| container_title | Neurosurgery |
| container_volume | 30 |
| creator | JOHNSON, D. L ERICKSON, R. E |
| description | An unusual presentation of Leigh's disease consisting of rapid progression of leg weakness in a young child is discussed. Magnetic resonance imaging revealed an intramedullary mass lesion of the conus medullaris. Surgical exploration revealed only necrosis and inflammation. Subsequent studies revealed pathology in the cerebrum as well as the spinal cord. Metabolic abnormalities confirmed the diagnosis of Leigh's disease. The differential diagnosis of intramedullary mass lesions demonstrated by magnetic resonance imaging should include metabolic, inflammatory, and ischemic processes as well as neoplastic disease. |
| doi_str_mv | 10.1097/00006123-199205000-00022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72948173</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72948173</sourcerecordid><originalsourceid>FETCH-LOGICAL-c284t-a22a49a6a145fc7d7acd11ad19752164c8f3f1534e2f118fc2ace505c35977193</originalsourceid><addsrcrecordid>eNpFkE1LxDAQhoMo67r6E4QcRE_VTD6aBk-y-AULXhS8lTFN10rbXTPtwX9vdNc1EMIw77zz5mGMg7gE4eyVSCcHqTJwTgqTqixdKffYFIzUmRZa7LOpAF1kyuWvh-yI6EMIyLUtJmwCptDK6Sm7XoRm-X5BvGooIAW-joFCPzT9kiNx7HnTDxG7UI1ti_GLd0jE20DNqj9mBzW2FE6274y93N0-zx-yxdP94_xmkXlZ6CFDKVE7zBG0qb2tLPoKACtw1sgUyBe1qsEoHWQNUNReog9GGK-MsxacmrHzje86rj7HQEPZNeRDytOH1UillU4XYFUSFhuhjyuiGOpyHZsupS5BlD_cyj9u5Y5b-cstjZ5ud4xv6bP_gxtQqX-27SN5bOuIvW9oJzMqmRmpvgGLSXQZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72948173</pqid></control><display><type>article</type><title>Leigh's disease presenting as an intramedullary mass lesion</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>JOHNSON, D. L ; ERICKSON, R. E</creator><creatorcontrib>JOHNSON, D. L ; ERICKSON, R. E</creatorcontrib><description>An unusual presentation of Leigh's disease consisting of rapid progression of leg weakness in a young child is discussed. Magnetic resonance imaging revealed an intramedullary mass lesion of the conus medullaris. Surgical exploration revealed only necrosis and inflammation. Subsequent studies revealed pathology in the cerebrum as well as the spinal cord. Metabolic abnormalities confirmed the diagnosis of Leigh's disease. The differential diagnosis of intramedullary mass lesions demonstrated by magnetic resonance imaging should include metabolic, inflammatory, and ischemic processes as well as neoplastic disease.</description><identifier>ISSN: 0148-396X</identifier><identifier>EISSN: 1524-4040</identifier><identifier>DOI: 10.1097/00006123-199205000-00022</identifier><identifier>PMID: 1584394</identifier><identifier>CODEN: NRSRDY</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Diagnosis, Differential ; Humans ; Leigh Disease - diagnosis ; Leigh Disease - diagnostic imaging ; Leigh Disease - surgery ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Spinal Cord Neoplasms - diagnosis ; Tomography, X-Ray Computed ; Ultrasonography</subject><ispartof>Neurosurgery, 1992-05, Vol.30 (5), p.774-776</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-a22a49a6a145fc7d7acd11ad19752164c8f3f1534e2f118fc2ace505c35977193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,778,782,787,788,23913,23914,25123,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5305052$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1584394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JOHNSON, D. L</creatorcontrib><creatorcontrib>ERICKSON, R. E</creatorcontrib><title>Leigh's disease presenting as an intramedullary mass lesion</title><title>Neurosurgery</title><addtitle>Neurosurgery</addtitle><description>An unusual presentation of Leigh's disease consisting of rapid progression of leg weakness in a young child is discussed. Magnetic resonance imaging revealed an intramedullary mass lesion of the conus medullaris. Surgical exploration revealed only necrosis and inflammation. Subsequent studies revealed pathology in the cerebrum as well as the spinal cord. Metabolic abnormalities confirmed the diagnosis of Leigh's disease. The differential diagnosis of intramedullary mass lesions demonstrated by magnetic resonance imaging should include metabolic, inflammatory, and ischemic processes as well as neoplastic disease.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>Leigh Disease - diagnosis</subject><subject>Leigh Disease - diagnostic imaging</subject><subject>Leigh Disease - surgery</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Spinal Cord Neoplasms - diagnosis</subject><subject>Tomography, X-Ray Computed</subject><subject>Ultrasonography</subject><issn>0148-396X</issn><issn>1524-4040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMo67r6E4QcRE_VTD6aBk-y-AULXhS8lTFN10rbXTPtwX9vdNc1EMIw77zz5mGMg7gE4eyVSCcHqTJwTgqTqixdKffYFIzUmRZa7LOpAF1kyuWvh-yI6EMIyLUtJmwCptDK6Sm7XoRm-X5BvGooIAW-joFCPzT9kiNx7HnTDxG7UI1ti_GLd0jE20DNqj9mBzW2FE6274y93N0-zx-yxdP94_xmkXlZ6CFDKVE7zBG0qb2tLPoKACtw1sgUyBe1qsEoHWQNUNReog9GGK-MsxacmrHzje86rj7HQEPZNeRDytOH1UillU4XYFUSFhuhjyuiGOpyHZsupS5BlD_cyj9u5Y5b-cstjZ5ud4xv6bP_gxtQqX-27SN5bOuIvW9oJzMqmRmpvgGLSXQZ</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>JOHNSON, D. L</creator><creator>ERICKSON, R. E</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>Leigh's disease presenting as an intramedullary mass lesion</title><author>JOHNSON, D. L ; ERICKSON, R. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-a22a49a6a145fc7d7acd11ad19752164c8f3f1534e2f118fc2ace505c35977193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Diagnosis, Differential</topic><topic>Humans</topic><topic>Leigh Disease - diagnosis</topic><topic>Leigh Disease - diagnostic imaging</topic><topic>Leigh Disease - surgery</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Spinal Cord Neoplasms - diagnosis</topic><topic>Tomography, X-Ray Computed</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JOHNSON, D. L</creatorcontrib><creatorcontrib>ERICKSON, R. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JOHNSON, D. L</au><au>ERICKSON, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leigh's disease presenting as an intramedullary mass lesion</atitle><jtitle>Neurosurgery</jtitle><addtitle>Neurosurgery</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>30</volume><issue>5</issue><spage>774</spage><epage>776</epage><pages>774-776</pages><issn>0148-396X</issn><eissn>1524-4040</eissn><coden>NRSRDY</coden><abstract>An unusual presentation of Leigh's disease consisting of rapid progression of leg weakness in a young child is discussed. Magnetic resonance imaging revealed an intramedullary mass lesion of the conus medullaris. Surgical exploration revealed only necrosis and inflammation. Subsequent studies revealed pathology in the cerebrum as well as the spinal cord. Metabolic abnormalities confirmed the diagnosis of Leigh's disease. The differential diagnosis of intramedullary mass lesions demonstrated by magnetic resonance imaging should include metabolic, inflammatory, and ischemic processes as well as neoplastic disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>1584394</pmid><doi>10.1097/00006123-199205000-00022</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-396X |
| ispartof | Neurosurgery, 1992-05, Vol.30 (5), p.774-776 |
| issn | 0148-396X 1524-4040 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72948173 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Diagnosis, Differential Humans Leigh Disease - diagnosis Leigh Disease - diagnostic imaging Leigh Disease - surgery Magnetic Resonance Imaging Male Medical sciences Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Spinal Cord Neoplasms - diagnosis Tomography, X-Ray Computed Ultrasonography |
| title | Leigh's disease presenting as an intramedullary mass lesion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A39%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leigh's%20disease%20presenting%20as%20an%20intramedullary%20mass%20lesion&rft.jtitle=Neurosurgery&rft.au=JOHNSON,%20D.%20L&rft.date=1992-05-01&rft.volume=30&rft.issue=5&rft.spage=774&rft.epage=776&rft.pages=774-776&rft.issn=0148-396X&rft.eissn=1524-4040&rft.coden=NRSRDY&rft_id=info:doi/10.1097/00006123-199205000-00022&rft_dat=%3Cproquest_cross%3E72948173%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72948173&rft_id=info:pmid/1584394&rfr_iscdi=true |